Resultados de investigación

Datos utilizados para la confección de "AntimiR-199a treatment protects against cardiac hypertrophy and fibrosis following myocardial infarction", como parte del trabajo completo "The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI", con DOI https://doi.org/10.1038/s41598-021-82745-9

Cuestionario para analizar la percepción de la competencia de Emprendimiento Digital para estudiantes universitarios que ha sido elaborado en el marco del proyecto EmDigital (financiado por la Fundación Séneca de la Región de Murcia).

En el marco del proyecto EmDigital (financiado por la Fundación Séneca de la Región de Murcia) hemos utilizado la técnica de la entrevista para analizar buenas prácticas de emprendimiento digital. Hemos entrevistado a 18 emprendedores digitales de éxito. Hemos optado por un tipo de entrevista semiestructurada y el procedimiento para la validación de la entrevista ha sido un juicio de expertos (método de agregados individuales).

Se presentan los datos obtenidos en la encuesta del proyecto DABE (de SEDEM y CEEM), en formato excel, para cumplir con los requisitos de Plos One de ofrecerlos en acceso abierto.

The association between stress and immune response activations in different diseases has been analyzed in this paper based on salivary analytics. Moreover, a first attempt to discriminate between diseases was performed by machine learning. The salivary analytics consisted of the measurement of physical (cortisol) and psychological stress (salivary alpha-amylase) indicators, innate (acute phase proteins: C-reactive protein and haptoglobin), and adaptive immune (adenosine deaminase, Cu and Zn) markers and oxidative stress parameters (antioxidant capacity and oxidative status). A total of 107 commercial growing pigs in the field were divided into six groups according to the signs of disease after proper veterinary clinical examination, specifically, healthy pigs, pigs with rectal prolapse, tail-biting, diarrhea, lameness or dyspnea. Associations between stress and immune markers were observed with different intensities. The higher associations (r = 0.61) were observed between oxidative stress markers and adaptive immune markers. On the other hand, moderate associations (r = 0.31-0.48) between physical and psychological stress markers with both innate and adaptive immune markers were observed. All pathological conditions showed statistically significant differences in at least 4 out of the 11 salivary markers studied, with no individual marker dysregulated in all the diseases. Moreover, each disease condition showed differences in the degree of activation of the systems analyzed which could be used to create different salivary profiles. A total of two dimensions were selected according to the machine learning analysis to explain the 48,3% of the variance of our data. Lameness and prolapse were the two pathological conditions most distant from the healthy condition followed by dyspnea. Tail biting and diarrhea were also far from the other diseases but nearer healthy animals. There is still room for improvements, but these preliminary results showed a great power for disease detection and characterization using salivary biomarkers profiling in the near future.