Resultados de investigación

Background. Sleeve gastrectomy (SG) is one of the most commonly performed bariatric surgeries is able to treat diabetes (T2DM) better than many drugs. The mechanisms that underlie this phenomenon remains unclear. We propose that somatostatin (SST), isoforms, SST-14 and SST-28, are key to explaining the pathophysiological mechanisms behind T2DM improvement after SG. Methods. We underwent surgeries on three groups of Wistar rats -fasting (FC), surgery control (Sham), and SG groups-. We measured plasma levels of glucose, insulin, SST-14 and SS-28 at several weeks after surgery, islet somatostatin receptor (SSTR) and cell populations at short and long-term after surgery. We performed a Pasireotide (SST-28 analogue) infusion assay in another group of rats to confirm the influence of SST-28 plasma levels on the delta-cell population. Results. We found an elevation of the insulin response after surgery in SG animals but a decrease in insulin response in the long-term with a loss of beta cell mass. An increase in duodenal SST-28-producing cells in the duodenum and a loss of pancreatic SST-14-producing cells was measured after SG but not in controls. The expression of SSTR-5 in delta-cell populations from every group and the ability of the Pasireotide infusion assay to decrease the delta-cell population indicate the effect of SST-28 plasma levels on delta-cell maintenance. Conclusion. After SG begins with a compensatory response in the duodenum, the depletion of beta cell mass after losing the brake that constitutes SST-14 at the paracrine level. This process may explain the percentage of T2DM relapse after SG.

This repository is composed of two different parts: Assessment data and Mutation Scores file contains the student-generated data used in the experience. Experience-material file contains the files to be able to reproduce the experience. The Experience-material file for the lab is used in two sessions: Session 1: Development and assessment of test suites In this session, the student has to develop a test suite for a program under test. At the end of the session, the test suite will be evaluated against a set of assessment criteria regarding the quality of the developed test suite. Files for this session: VVS-Lab6-S1 pdf file , with the description of this session. Material-S1 zip file, with the files required to complete this session. Session 2: Evaluation applying mutation testing with MuCPP In this session, the test cases designed in the first part of this lab will be evaluated based on the mutation adequacy criterion. This will be done by using the MuCPP mutation tool. Files for this session: VVS-Lab6-S2 pdf file, with the description of this session. Material-S2 zip file, with the files required to complete this session. The source code files family.[cpp|hpp] have been adapted from a listing in [1]. Note that, while considered to be fault free in this lab, these source files are used in other sessions where students are expected to detect some defects in them.

Esa base de datos contiene 1.082 mensajes de Twitter publicados desde 1 de enero a 31 de diciembre de 2022 por los perfiles oficiales de Twitter de los gestores turísticos más activos en las comunidades autónomas de España.

Endometrial cancer (EC) is the 4th most common neoplasm of the female genital tract, with 15–20% of patients being of high risk of recurrence which leads to a significant decrease in patient survival. Current therapeutic options for patients with EC are poor, being the combined therapy of carboplatin and paclitaxel the standard of care, with limited efficacy. Therefore, new therapeutic options and better monitoring tools are needed to improve the management of the disease. In the current case report, we showcase the value of liquid biopsy analyses in a microsatellite instability EC patient with initially good prognosis that however underwent rapid progression disease within 6 months post-surgery; through the study of plasma cfDNA/ctDNA dynamics to assess the tumour evolution during treatment, as well as the study of the uterine aspirate as a valuable sample that captures the intra-tumour heterogeneity that allows a comprehensive genomic profiling of the disease to identify potential therapeutic options. Furthermore, preclinical models were generated at the time of tumour progression to assess the efficacy of the identified targeted therapies

Trial identifier: NCT04357808, Background: The use of IL-6 blockers in COVID-19 hospitalized patients has been associated with a reduction in mortality compared to standard care. However, many uncertainties remain pertaining to optimal intervention time, administration schedule, and predictors of response. To date, data on the use of subcutaneous sarilumab is limited and no randomized trial results are available. Methods: Open label randomized controlled trial at a single center in Spain. We included adult patients admitted with microbiology documented COVID-19 infection, imaging confirmed pneumonia, fever and/or laboratory evidence of inflammatory phenotype, and no need for invasive ventilation. Participants were randomly assigned to receive sarilumab, a single 400 mg dose in two 200 mg subcutaneous injections, added to standard care or standard care, in a 2:1 proportion. Primary endpoints included 30-day mortality, mean change in clinical status at day 7 scored in a 7-category ordinal scale ranging from death (category 1) to discharge (category 7), and duration of hospitalization. The primary efficacy analysis was conducted on the intention-to-treat population. Results: A total of 30 patients underwent randomization: 20 to sarilumab and 10 to standard care. Most patients were male (20/30, 67%) with a median (interquartile range) age of 61.5 years (56-72). At day 30, 2/20 (10%) patients died in the sarilumab arm vs. none (0/10) in standard care (Log HR 15.11, SE 22.64; p = 0.54). At day 7, no significant differences were observed in the median change in clinical status (2 [0-3]) vs. 3 [0-3], p = 0.32). Median time to discharge (days) was similar (7 [6-11] vs. 6 [4-12]; HR 0.65, SE 0.26; p = 0.27). No significant differences were detected in the rate of progression to invasive and noninvasive mechanical ventilation. Conclusions and relevance: Our pragmatic pilot study has failed to demonstrate the benefit of adding subcutaneous sarilumab to standard care for mortality by 30 days, functional status at day 7, or hospital stay. Findings herein do not exclude a potential effect of sarilumab in severe COVID-19 but adequately powered blinded randomized phase III trials are warranted to assess the impact of the subcutaneous route and a more selected target population

This Clinical Trial was registered on clinicaltrials.gov under the numberNCT03701906, Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org), Objective: To evaluate the effect of a new probiotic strain combination, Ligilactobacillus salivarius subsp infantis PS11603 and Bifidobacterium longum PS10402, on gut bacterial colonization of preterm infants. Methods: A randomized, double-blind, placebo-controlled study was conducted in preterm infants from 28 weeks + 0days to 30 weeks + 6days of gestation. Thirty preterm infants were randomly selected after birth to receive either probiotics or placebo. Stool samples were collected before product intake and then sequentially during the first weeks of their admission. Classical microbiological, metagenomics and multiplex immunological analyses were performed to assess the bacterial and immune profile of the samples. Results: Twenty-seven infants completed the study (14 vs 13, probiotic and placebo groups). A higher number of participants were colonized by Lactobacilli in the probiotic group than in the placebo group (93% vs 46%; P = 0.013). Similar results were obtained when analysing bifidobacterial colonization (100% vs 69%; P = 0.041). Earlier colonization was observed in the probiotics group versus the placebo group, specifically 5 weeks for Lactobacillus and 1 week for Bifidobacterium. Although no effect was observed in the faecal immunological profile, a decreasing trend could be observed in Th17 response during the first week of probiotic treatment. None of the adverse events (AEs) registered were related to product intake. Conclusion: Probiotic supplementation with L salivarius PS11603 and B longum subsp. infantis PS10402 enhanced an earlier colonization of Lactobacillus and Bifidobacterium in preterm infants’ guts in 5 and 1 week, respectively. A higher number of infants were colonized by Lactobacilli with the probiotics’ intake at the end of the study, This work was funded by Probisearch SLU

A 45-year-old woman developed an intermittent gait disorder and agoraphobia that was initially diagnosed as a functional movement disorder (FMD). On examination, fluctuating stiffness of the left leg with a hung-up reflex was observed (Video 1). Neuroimaging and laboratory tests were normal, including thyroid function. Electromyography showed continuous motor unit activity in the muscles of the left leg. Elevated levels of GAD65 antibodies were detected in serum (>2,000 U/mL) and cerebrospinal fluid (21.09 U/mL), findings consistent with stiff limb syndrome, a rare variant of stiff-person syndrome (SPS). The patient’s symptoms improved with diazepam treatment. The hung-up reflex has classically been described in hypothyroidism and Huntington disease, and this case suggests that it may also occur in SPS. This clinical sign should therefore be considered when evaluating patients initially suspected of having FMD., Si

Background: Tooth autotransplantation is defined as the surgical repositioning of an autogenous tooth in another surgical site within the same individual. Aim: The aim of this research was to analyze the outcome of tooth transplantation using immature donor teeth compared with closed apex teeth and to compare differences between donor tooth positions on the arch. Methods: Electronic and manual literature searches were performed in different databases, including the National Library of Medicine (MEDLINE), EMBASE (OVID), Cochrane Central (CENTRAL), and the digital library of the Universitat Internacional de Catalunya (UIC University) from 1978 to March 2021. Studies were selected when they fulfilled the following criteria: only human prospective clinical studies, minimum sample size of 10 patients, minimum follow-up of 1 year, studies reporting or with at least deducible data on survival rates, immediate tooth autotransplantation with completed or incomplete root formation, and publications in the English language. A meta-analysis of random effects was developed to estimate the global effect measure of the survival rate, success rate, and root resorption involving the total sample, as well as open- and closed-apex groups. Results: Twenty-four articles were eligible for analysis. The Cohen’s kappa corresponding to this review was 0.87, and the risk assessment was considered low–moderate for the included studies. Overall survival and success rates were 95.9% and 89.4%, respectively, with a mean follow-up of 4 years and an overall mean age of 25.2 ± 12.3 years. Closed apex teeth showed a survival rate of 3.9% lower than that of open apex teeth. Higher complication rates were found for both inflammatory external root resorption and replacement root resorption in the closed-apex group, without reaching statistical significance. Conclusions: Tooth autotransplantation is a viable treatment alternative, regardless of the apical condition, with high survival and success rates after a mean follow-up of 4 years. Open-apex donor teeth could be considered the gold-standard option, showing lower complication rates when compared to closed-apex donor teeth. Future randomized controlled clinical studies are needed to examine the long-term prognosis of this technique., info:eu-repo/semantics/publishedVersion

“UPSIDE DOWN, Nuestro mundo, nuestro tiempo” hace referencia a la inestabilidad de los tiempos que vivimos en el marco de la pandemia del COVID 19 y la sombra de la Tercera Guerra Mundial, a veces encerrados y otras con libertad. Nada es como era, todo ha cambiado. La intuición hace que lo mejor sea permanecer quieto, parado e inmóvil, mientras la vida sigue transcurriendo a gran velocidad, especialmente en entornos digitales y virtuales. Con esta propuesta se realiza un viaje a través de un recorrido en un espacio virtual decadente, en formato de videojuego con las modelos convulsionados y paralizados en el tiempo, nuestro tiempo. Muchas de las prendas expuestas están diseñadas y confeccionadas utilizando el método experimental de patronaje Accidental Cutting, propiedad intelectual de Eva Iszoro, diseñadora y fundadora de la marca Accidental Cutting. Esta vez la experimentación se extiende también al diseño textil de estampados, escaneando objetos cotidianos, muchos de ellos sin valor, como pinceles, reglas, bolsas de plástico, que se mezclan con piezas de joyería de Accidental Cutting, recortes de metacrilato y la etiqueta de la marca. En esta colección se utiliza un único avatar, el de la autora de este proyecto: Eva Iszoro, que se convierte en un elemento que participa activamente en el desfile. La música fue compuesta por Johnny Paradiso @johnnyinparadise. Esta colección fue presentada tres días antes de la invasión rusa de Ucrania., “UPSIDE DOWN, Nuestro mundo, nuestro tiempo” es una colección de moda virtual, para la primavera verano 2023, presentada en la pasarela de moda internacional London Fashion Week LFW en febrero de 2022. El fashion film de esta colección de autoría de Eva Iszoro para su marca de moda Accidental Cutting fue nominada a premios en London Fashion Film Festival y el Berlin Fashion Film Festival en la categoría de animaciones digitales 2D y 3D. Música Johnny Paradiso. https://accidentalcutting.com/upside-down_our-world-our-time-aw-22-23/ https://www.youtube.com/watch?v=s9mOh7z5iT0

“EMPTINESS”, la colección de moda virtual de Eva Iszoro para Primavera/Verano 2023, pretende transmitir conceptos de aislamiento, paso del tiempo, finales, juventud y vejez. En definitiva, es una reflexión sobre la vida y la muerte. Aunque el acto de duelo cobra protagonismo en esta colección, y tiene bastante actualidad tras la muerte de la reina Isabel II de Inglaterra, la colección fue diseñada antes de su muerte. Al mismo tiempo, hay lugar para una interpretación más positiva referida a agradables momentos veraniegos de relajación o sensación de flotación. Para esta colección se crea un escenario bien definido, una auténtica cápsula o burbuja aislada, con un microclima específico en su interior. Aunque el proyecto fue creado íntegramente en realidad virtual, los avatares corresponden a personas reales de diferentes edades y han sido obtenidos mediante procesos de fotogrametría y retopología. Una de estas personas tiene un significado muy personal para el diseñadora de Emptiness, y la colección es una especie de homenaje a esta persona. Al mismo tiempo, abraza la idea de que la moda y el diseño no deben limitarse a cuerpos que tienen una edad o apariencia estandarizada. La mayoría de las prendas de esta colección están creadas con patrones únicos, aplicando el método de patronaje Accidental Cutting, de formas irregulares sin tallas específicas, que se pueden ajustar a cualquier tipo de cuerpo mediante tirantes y cinturones. “Emptiness” no es sólo una colección de moda sino también un experimento artístico de realidad virtual., EMPTINESS para Primavera Verano 2023, es una colección de moda virtual, de autoría de Eva Iszoro para su marca Accidental Cutting, presentada en la Semana de la Moda de Londres (London Fashion Week) en septiembre de 2022. Se mostró en 2D VR y 3D 360º VR para gafas de realidad virtual. En este proyecto de moda se utilizaron avatares de modelos reales utilizando técnicas de fotogrametría y retopología. Esta película fue nominada a premios en el London Fashion Film Festival y en el Berlin Fashion Film Festival en la categoría de animaciones digitales 2D y 3D. https://accidentalcutting.com/emptiness/ 2D_ https://www.youtube.com/watch?v=OsYohWnqmsE 3D_ 360º_ https://www.youtube.com/watch?v=T7Qg0zjthG8 https://londonfashionweek.co.uk/designers/accidental-cutting