Resultados de investigación

Soluble sST2 isoform is related to cardiotoxicity. Led by the Lax´s team, preliminary data have identified for first time a relationship between higher sST2 levels and YY1 with CIC, using an in vitro translational model

Cantharidin is a natural compound with known therapeutic applications in humans. However, its properties have hardly been studied in fish. The aim of this study was to investigate the in vitro effects of cantharidin on gilthead seabream (Sparus aurata) head kidney leucocytes (HKL) stimulated with λ-carrageenan. Thus, HKLs were incubated for 24 h with cantharidin (0, 2.5 and 5 μg mL-1) and λ-carrageenan (0 and 1,000 μg mL-1) and cell viability and morphology, immunological parameters and several selected genes related to inflammation and apoptosis were evaluated. The results showed that cantharidin only decreased HKL viability when incubated with the highest dose (5 μg mL-1) and in combination with λ-carrageenan. As for the immunological parameters studied, cantharidin increased the peroxidase activity of HKLs only when incubated in combination with λ-carrageenan, but inhibited the respiratory burst and phagocytic activities even after being previously increased by λ-carrageenan. Furthermore, cantharidin induced morphological changes in HKLs with apoptotic and vacuolization signs that were enhanced when incubated in combination with λ-carrageenan. Considering the analysis of gene expression in HKLs, although λ-carrageenan up-regulated the expression of the proinflammatory gene il1b, cantharidin down-regulated its expression in HKLs exposed to both λ-carrageenan and cantharidin. In addition, cantharidin up-regulated casp3 and casp9 expression, which was down-regulated in HKLs incubated with both molecules. This combination also up-regulated casp1 expression. The present results provide detailed insight into the immune-depressive and anti-inflammatory properties of cantharidin on immune cells, which could be of interest to the aquaculture sector.

Datos espacio-temporales sintéticos generados con un modelo de simulación sobre la propagación de una infección por una bacteria multirresistente en pacientes ingresados en un hospital.

Extracción de datos de 25 artículos científicos seleccionados para una scoping review sobre el uso de dispositivos portátiles con inteligencia artificial para el cuidado de personas mayores., Extracción de datos de 25 artículos científicos seleccionados para una scoping review sobre el uso de dispositivos portátiles con inteligencia artificial para el cuidado de personas mayores.

Datos de investigación del articulo cientifico: "Sportspersonship orientation in the Training Process of Young Football Players in Different Training Contexts", Datos de investigación del articulo cientifico: "Sportspersonship orientation in the Training Process of Young Football Players in Different Training Contexts"

This manuscript version is made available under the CC-BY-NC-SA 4.0 license http://creativecommons.org/licenses/by-nc-sa/4.0/.

Entrevistas anonimizadas

Datasets relacionados con el artículo "Implementing the use of layered double hydroxides as photocatalytic additive for DeNOx building mortars: ZnCr-CO3 a case of study" disponible en: https://doi.org/10.1016/j.conbuildmat.2023.132241