Resultados de investigación

CHIR99021, also known as laduviglusib or CT99021, is a Glycogen-synthase kinase 3β (GSK3β) inhibitor, which has been reported as a promising drug for cardiomyocyte regeneration or treatment of sensorial hearing loss. Since the activation of dopamine (DA) receptors regulates dopamine synthesis and they can signal through the β-arrestin pathway and GSK3β, we decided to check the effect of GSK3β inhibitors (CHIR99021, SB216763 and lithium ion) on the control of DA synthesis. Using ex vivo experiments with minces from rat brain striatum, we observed that CHIR99021, but not SB216763 or lithium, causes complete abrogation of both DA synthesis and accumulation, pointing to off-target effects of CHIR99021. This decrease can be attributed to tyrosine hydroxylase (TH) inhibition since the accumulation of L-DOPA in the presence of a DOPA decarboxylase inhibitor was similarly decreased. On the other hand, CHIR99021 caused a dramatic increase in the DOPAC / DA ratio, an indicator of DA metabolization, and hindered DA incorporation into striatum tissue. Tetrabenazine, an inhibitor of DA vesicular transport, also caused DA depletion and DOPAC / DA ratio increase to the same extent as CHIR99021. In addition, both CHIR99021 or SB216763, but not lithium, decreased TH phosphorylation in Ser19, but not in Ser31 or Ser40. These results demonstrate that CHIR99021 can lead to TH inactivation and DA depletion in brain striatum, opening the possibility of its use in DA-related disorders, and shows effects to be considered in future clinical trials.

Location in the climatic niche over several years of plant comunities from a field manipulation experiment of climate change carried on in Garraf (Spain). 1. Description of methods used for collection-generation of data: Field data: vegetation surveys based on transects within experimental plots Species distribution data: species occurrences along their geographical distributions were obtained from the database of the Global Biodiversity Information Facility GBIF 2019, ) Climate data: climatic variables were obtained for the period 1979-2013 at 1-km2 resolution from CHELSA v.1.2 database Karger et al. (2018) DOI: 10.1038/sdata.2017.122; Karger et al., (2017) DOI: 10.16904/envidat.228.v2.1 See details in DOI: 10.1111/1365-2745.14233 2. Methods for processing the data: A principal component analysis (PCA) was applied to reduce the dimensionality of the 13 climatic variables to the first two PCA axes. The species occurrences from the geographic space were translated into the two-dimensional climatic space defined by the two PCA axes. A two-dimensional kernel density function was applied to the species occurrences in the climatic space. The centroid of each species niche was obtained as the center of gravity of the niche. The observed climate at the study site for the average of the experimental period 1999-2014 and for each year were translated into the two-dimensional climatic space. The Euclidean distance in the climatic space between community location (based on species centroid averaged weighed by species's abundance) and the location of the observed climate in the respective years was calculated.

The data set contains the experimental results of the figures shown in the article, including the figures in the supplementary materials. They were used to characterize the texture of the samples (adsoption/desoption of gases), it crystalline nature and modification due to temperature and/or gas pressure variations, and their thermal estability.

Raw data of a set of experiments aimed to evaluate the influence of hydrophilic carbon and nitrogen sources on the production of deacetylated lactonic C18:1 sophorolipid focusing on the variation of glucose and urea ratio by applying a Box-Behnken design (BBD)

Datos que contienen variables sociodemográficas y percepción de machismos cotidianos de estudiantes de enfermería tanto en el aula como en prácticas.

This dataset contains data on networks of relationships between intellectuals, organizations, and events related to the Ibero-American film field. Specifically, we reconstruct a network among Ibero-American film clubs and the personal networks of three women: the Argentinean intellectual Victoria Ocampo, the Spanish journalist María Luz Morales, and the Mexican photographer Lola Álvarez Bravo. This dataset allows us to explore the relationships of the aforementioned actors with other intellectuals, events and organizations by expanding the range of their relationships and activities via the “follow the actor” tenet of Bruno Latour’s Actor-Network Theory. The files contain the necessary data to reproduce the visualizations included in the PhD thesis entitled “Networks of Empowerment: Women in the Early Ibero-American Film Clubs (1909 to 1959)”, authored by Ainamar Clariana-Rodagut (please see chapters 2.3, 3.1, 3.2 and 3.3). These visualizations are also available online in their interactive version at [https://global-ls.github.io/filmculture-socnet/]. The visualizations have been created using the open graph visualization software Gephi 0.10.1, (https://gephi.org/), but can be obtained with any other network visualization tool.

The following dataset corresponds to the bibliographic data analysed in the publication titled 'Wikipedia Gender Gap: A Scoping Review'. The data is used for a scoping review assessing results on the content gap, editing and participation bias, readership imbalances, and strategies to mitigate the gender gap. Furthermore, it explores the repercussions of this gap and categorizes the contributing factors as “the women’s problem,” “the mirror effect,” and “the systemic problem.” Overall, this comprehensive review enhances our comprehension of the Wikipedia gender gap and provides valuable insights into the research landscape in this domain. The results of the review are available in the related publication.

The dataset refers to the study of the pottery production at the site of Roca Vecchia (Melendugno-Lecce, IT) as part of the Roca Archaeological Survey project (RAS) of the University of Bologna (Italy). Roca (or Rocavecchia or Roca Vecchia) was one of the most important sites for the Bronze Age of the Central Mediterranean, which shows a complex history of building and destruction phases and the interactions of different cultural groups. 68 ceramic individuals were sampled spanning from the Middle to the Final Bronze Age phases of the site aiming at exploring how changes in the settlement are matched in technological choices made by the people responsible for the production of impasto (local) pottery at Roca

The file contains all the formalisations that have been proposed in order to be able to carry out the checks of the doctoral thesis. The file is a script ordered by universal and where other more precise or alternative linguistic formalisations related to the analysed universal are also shown. The application of this script on the first 1000 treebanks of all the Universal Dependencies corpora (2.11) is what guides the results of the thesis.

La Cátedra Fundación MAPFRE Canarias de Tecnología y Educación de la Universidad de La Laguna presenta la colección audiovisual “Testimonios sobre la Educación en Canarias”. Una iniciativa destinada a recoger las voces de personajes relevantes en los acontecimientos de la Educación en Canarias. Este material audiovisual, en formato de entrevistas, ahonda en relatar desde la perspectiva de los propios protagonistas, momentos cruciales de la historia en Canarias que han permitido dar forma a la actual educación canaria. En este episodio participan algunos miembros del colectivo MAVIE: Manuel Ortiz, maestro, Director del Centro Adultos de S. Cristóbal de La Laguna y miembro de MAVIE José María Hernández maestro y miembro de MAVIE Nazario Prieto maestro, miembro de MAVIE y técnico del Programa Medios Audiovisuales de la Consejería de Educación de Canarias Raúl Díaz maestro y miembro de MAVIE José Pestano, maestro, profesor de la Universidad La Laguna, y técnico del Programa Medios Audiovisuales de la Consejería de Educación de Canarias Miguel Vilas maestro y miembro de MAVIE