Resultados de investigación

Exercise therapy is the first-line treatment in rotator cuff-related shoulder pain (RCRSP), and diverse types of exercise seem effective. However, it is not still clear if painful exercise should be allowed or avoided during exercises. The objective of this study was to investigate if exercise into pain is more effective than no pain in RCRSP. A randomized controlled trial was conducted in a physiotherapy clinic in Belgium. Forty-three participants with chronic RCRSP were randomly allocated to G1 (exercising into pain) or G2 (exercising without pain) in a 12-week intervention with 6-month follow-up. Primary outcome was the Shoulder Pain and Disability Index (SPADI); secondary outcomes were pain intensity, fear-avoidance beliefs, fear of pain, quality of life, strength, and range of motion. Outcomes were measured at baseline (T0), after 9 weeks (T1), 12 weeks (T2), and 6 months (T3) from the first session and analysed with linear mixed models. No between-group difference in SPADI (time-by-group interaction, p = 0.25) up to 6 months was found, with mean difference (G1-G2) at T1 = 5.78 (CI95%: -3.43,14.59; p = 0.33), at T2 = 0.93 (CI95%: -7.20,9.05; p = 0.82), at T3 = 4.15 (CI95%: -2.61,10.92; p = 0.33). No between-group differences were found for any other outcomes. Pain provocation seems not to be necessary in RCRSP for achieving successful treatment effect in pain and disability reduction, fear-related beliefs, and quality of life up to 6 months. ClinicalTrials.gov NCT04553289., Si

Comparar la calidad de vida en personas que viven con infección por el Virus de la Inmunodeficiencia Humana según el modelo de Atención Farmacéutica que reciben en los Servicios de Farmacia Hospitalaria: CMO (capacidad, motivación y oportunidad), versus seguimiento convencional. Método. Estudio longitudinal, prospectivo, multicéntrico, realizado entre octubre de 2019 y noviembre de 2021 en 14 Servicios de Farmacia Hospitalaria de España. Se incluyeron pacientes mayores de 18 años, que recibían tratamiento antirretroviral y acudían a las consultas de Atención Farmacéutica durante ≥1 año, excluyéndose aquellos sin autonomía para completar los cuestionarios previstos. Los centros fueron aleatorizados a seguir utilizando la misma sistemática de trabajo (seguimiento tradicional) o implementar el modelo CMO, utilizando la estratificación, el establecimiento de objetivos farmacoterapéuticos, el uso de entrevista motivacional y el seguimiento longitudinal con nuevas tecnologías. La variable principal fue la diferencia en el número de dimensiones afectadas negativamente, en cada rama, a las 24 semanas, según el cuestionario MOS-HIV. En el brazo CMO se registraron las intervenciones más frecuentemente realizadas. Resultados. Se incluyeron 151 pacientes, con una mediana de edad de 51,3 años. Se encontró una mejora significativa de la calidad de vida al final del seguimiento en el grupo CMO, reduciéndose el número de pacientes con dimensiones afectadas negativamente (2/11 vs 8/11). Las intervenciones más frecuentes llevadas a cabo, según la taxonomía, fueron motivación (51,7%) y revisión y validación del tratamiento antirretroviral (49,4%). Conclusiones. La calidad de vida de los pacientes es superior en aquellos centros que desarrollan Atención Farmacéutica basada en la metodología CMO en comparación con el seguimiento tradicional., To compare quality of life, in patients living with HIV infection with pharmaceutical care according to the CMO methodology: capacity, motivation and opportunity versus conventional follow-up. Longitudinal, prospective, multicenter, health intervention study, conducted between October 2019 and November 2021 in 14 centers throughout Spain. Patients over 18 years of age, receiving antiretroviral treatment and attending the consultations of the participating Pharmacy Services for 1 year were included. Patients who did not have the autonomy to complete the planned questionnaires were excluded. At baseline, participating centers were randomized to continue using the same systematics of work (traditional follow-up) or to implement the CMO model using patient stratification models, goal setting in relation to pharmacotherapy, use of motivational interviewing, as well as longitudinal follow-up enabled by new technologies. The main variable was the difference in the number of dimensions positively affected in each follow-up arm at 24 weeks of follow-up according to the MOS-HIV questionnaire. In the CMO group, the interventions performed the most frequently were recorded. 151 patients were included. The median age was 51.35 years. A significant improvement in quality of life was found at the end of follow-up in the CMO group, reducing the number of patients with negatively affected dimensions (2/11 vs 8/11). The most frequent interventions carried out in the CMO group, according to the taxonomy, were Motivation (51,7%) and review and validation (49,4%). The quality of life of patients is higher in those centers that develop Pharmaceutical Care based on the CMO methodology compared to traditional follow-up., Si

Carboplatin and paclitaxel (CP) have been the standard of care for advanced/recurrent endometrial cancer (EC) for many years. However, this chemotherapy combination shows limited efficacy and recurrences often occur in less than 12 months. ABTL0812 is a novel drug that selectively kill cancer cells by cytotoxic autophagy and has shown anticancer efficacy in preclinical models of EC in combination with CP. ENDOLUNG was an open-label, phase 1/2 clinical trial designed to determine the safety and efficacy of Ibrilatazar (ABTL0812) with CP in patients with advanced/recurrent EC and non-irradiable stage III and IV squamous non-small cell lung cancer (sq-NSCLC). The phase 1 part consisted of a 3 + 3 de-escalation design followed by an expansion cohort with 12 patients. The primary endpoint was safety. ABTL0812 starting dose was 1300 mg tid combined with carboplatin at area under the curve (AUC) 5 and paclitaxel at 175 mg/m2 both administered every 21 days for up to 8 cycles. The phase 2 part included a total of 51 patients. The primary endpoint was overall response rate (ORR) and the secondary endpoints included duration of response (DOR), progression-free survival (PFS) and overall survival (OS). During the phase 1 only one dose limiting toxicity (DLT), a grade 4 neutropenia, was observed in 1 out of 6 patients, thus no de-escalation was applied. One additional DLT, a grade 3 febrile neutropenia, was observed in the expansion cohort, thus the recommended phase 2 dose (RP2D) for ABTL0812 was established at 1300 mg tid. Most frequent hematological adverse events (AE) of the combination were neutropenia (52.9%), anemia (37.3%) and thrombocytopenia (19.6%). Nausea (66.7%), asthenia (66.7%), diarrhea (54.9%) and vomiting (54.9%) were the most frequent non-hematological adverse events (AEs). The combination of ABTL0812 plus CP showed an ORR of 65.8% (13.2% complete response and 52.6% partial response) with a median DOR of 7.4 months (95% CI: 6.3-10.8 months). Median PFS was 9.8 months (95% CI: 6.6-10.6) and median OS 23.6 months (95% CI 6.4-ND). Pharmacokinetic parameters were compatible with target engagement observed in preclinical studies, and blood pharmacodynamic biomarkers indicated sustained target regulation during, at least, 28 days after starting the treatment. This study suggests that the combination of ABTL0812 with CP is safe and feasible with an encouraging activity in patients with advanced/recurrent EC. Our data warrant further confirmation in prospective randomized trials. EU Clinical Trial Register, EudraCT number 2016-001352-21 and National Clinical Trials Number, NCT03366480. Registration on 19 September 2016., Si

NMR, ATR-FTIR and Mass Spectra of small molecules and monomers: {1-[3,5-bis(trifluoromethyl)phenyl]-3-cyclohexylthiourea} (TU) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS 3-(Prop-2-yn-1-ylthio)-propane-1,2-diol (1) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS, ESI-HRMS 4-[(Prop-2-yn-1-ylthio)methyl]-1,3-dioxolan-2-one (2) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS, ESI-HRMS Five-membered bis(cylic carbonate) (Monomer A) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-HRMS Five-membered bis(cylic carbonate) (Monomer E) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS, ESI-HRMS NMR, ATR-FTIR spectra and GPC chromatograms of polymers: PHU A-DETA [monomer A + diethylenetriamine (DETA)] 1H NMR, COSY, HSQC, ATR-FTIR, GPC (samples P2, P4-P20) PHU E-DETA [monomer E + diethylenetriamine (DETA)] 1H NMR, 13C NMR, ATR-FTIR, GPC (samples P1-P5) PHU E-HMDA [monomer E + hexamethylenediamine (HMDA)] 1H NMR, 13C NMR, ATR-FTIR, GPC (samples P1-P5)

En este documento se recogen 160 memes sobre contenido político, difundidos en las redes sociales entre 2017 y 2019, a raíz de la celebración de diversos procesos electorales en España. Estos fueron recopilados por Ana Mancera Rueda en el transcurso del proyecto PRODISNET-02: “Procesos discursivos en Internet: desplazamientos enunciativos y efectos hiperbólicos en el discurso político” (Ministerio de Ciencia, Innovación y Universidades). Algunos de ellos forman parte del corpus de análisis que posteriormente daría lugar a la monografía Mancera Rueda, Ana y Ana Pano Alamán (2020): La opinión pública en la red. Análisis pragmático de la voz de los ciudadanos, Madrid/Frankfurt, Iberoamericana/Vervuert. Se incluyen como dataset, ya que su estudio podría ayudar a otros investigadores a analizar la evolución de la comunicación política en las redes sociales durante el siglo XXI.

Los datos que aquí se presentan han sido obtenidos en el seno del proyecto “Cuba y Andalucía en el siglo XIX: estudio de los lazos lingüísticos y culturales desde las Humanidades Digitales” (US-1263104), financiado por la Junta de Andalucía con fondos FEDER y liderado por Eva Bravo García y Ana Mancera Rueda, catedráticas de Lengua Española de la Universidad de Sevilla. En dicho proyecto, Ana Mancera se ha dedicado a la consulta de fondos hemerográficos de distinta procedencia, con el fin de elaborar la monografía La prensa española ante la guerra de Cuba (1895-1898), publicada en la editorial Tirant lo Blanch en 2022. Los dataset generados contienen la transcripción de 108 editoriales sobre la guerra de Cuba publicados en tres diarios editados en Madrid durante el siglo XIX: El Imparcial, El Liberal y Heraldo de Madrid. El primero de ellos, de ideología liberal, fue fundado en 1867 por Eduardo Gasset y se convirtió en el periódico más influyente en la España del último tercio del siglo XIX; según Mariano de Cavia, su historia era “la historia misma de España desde las vísperas de la Revolución de septiembre” (“Cincuenta años en El Imparcial”, 16-III-1917). El Liberal surgió en 1879 por la disidencia de algunos redactores de El Imparcial, de ideología republicana, que se mostraron disconformes con la mudanza ideológica de este último diario, al aceptar el régimen monárquico alfonsino. Por último, el Heraldo de Madrid nació en 1890 como una publicación vespertina, aunque llegará a publicar diversas ediciones diarias. En 1893 fue adquirido por José Canalejas, uno de los líderes del Partido Liberal. Estos fueron los tres periódicos de mayor tirada durante el periodo de la Restauración, de ahí el interés que puede suscitar su estudio para cualquier investigador interesado en esta época.

Based on a review of the literature spanning from 1902 to 2021, we identify three existing indices and propose a novel one. We utilize meteorological data from the period 2000-2021 and the REVIP dataset (Red de Vigilancia de Isótopos en Precipitación) to create four maps (four shapefiles) of the Iberian Peninsula, each corresponding to one of these indices: - De Martonne index based on the average annual temperature and rainfall. The critical value of 10 is established and values between 10 and 20 indicate a Mediterranean climate. - Mediterranean index calculated by summing the average potential evapotranspiration and the average precipitation during the summer (January, August, and September). The critical threshold of 2.5, and if this value is exceeded, it indicates a Mediterranean climate. - Index based on the subtraction between two Pearson's correlation coefficients (r): the North Atlantic Oscillation index (NAOi), such as the difference between the standardized values of surface air pressure values in Iceland (Reykjavik) and the south-western part of the Iberian Peninsula (Gibraltar); and the Western Mediterranean Oscillation index (WeMOi), such as the difference between San Fernando (Spain) and Padua (Italy), along with precipitation for October, November, December, January, February and March. The critical threshold of 0 is established, and values exceeding this threshold classify the climate as Mediterranean. - Index based on tritium activity concentration in precipitation collected by REVIP. This system has been continuously operated since 2000, overseen by the Centre for Studies and Experiments in Public Works (CEDEX). This index is determined by calculating the first quartile of the distribution of tritium values for a specific meteorological station, with the critical threshold of 3.5. Exceeding this threshold indicates a Mediterranean climate.

In this research, we used a convenience sampling and selected two high schools located in Areas in Need of Social Transformation in Seville (southern Spain). We studied the learner identity of all their students in the first and second grade of secondary postcompulsory education (N = 70). These students present a trajectory of resilience, as they remained in the education system despite facing many difficulties. In this exploratory research, their identity as learners was analysed through an interview applied in a focus group format (N = 12), where their supports, strengths and psycho-social obstacles that facilitate/ hinder their stay in the education system in the post-compulsory stage were also identified. Datasets show the instrument used for data collection, consisting of the LIRESI semi-structured interview script to be applied in focus groups, as well as the coding manual for the responses obtained in the interviews (narratives of the participants), that were fully transcribed., LIRESI Guión Grupo Focal v.1 LIRESI Manual de Codificación v.1

La reflexión es un componente vital en las prácticas docentes profesionales. La idea de la que parte la reflexión misma es la importancia de la agencia de los futuros docentes en su propio desarrollo profesional. Nuestro estudio tiene sus raíces en investigaciones recientes sobre la necesidad de apoyar procesos de reflexión entre los estudiantes de magisterio. Desde una perspectiva histórico-cultural, nuestro objetivo es analizar las interacciones discursivas que tienen lugar durante los seminarios colaborativos en una experiencia de innovación dentro de un Prácticum reflexivo, y describir cómo los tutores universitarios apoyan y fomentan la reflexión sobre la práctica. Utilizamos un diseño de casos múltiples en el que cada caso es una unidad de aula formada por una tutora y sus alumnos. El Dataset aporta los informes preliminares de dos de estos casos, con los análisis descritos por objetivos. Cada uno de los casos está descrito en tres partes, que se corresponden con la descripción de los resultados correspondientes a los diferentes análisis realizados, la caracterización de los casos estudiados en función de la formulación de los objetivos del proyecto y la descripción del propósito compartido de la reflexión que construyen conjuntamente los participantes en el caso., Informe v.1 Caso A Informe v.1 Caso B

Este conjunto de datos contiene la digitalización de las centrales solares en Andalucía, incluyendo tanto fotovoltaicas como termosolares, hasta el año 2019. El conjunto de datos detalla la potencia instalada, área ocupada, y si la entrada es provisional o definitiva.