Resultados de investigación

Se presenta el primer protocolo inducido por luz visible para la preparación general de tiocianatos alquenilos a partir de bromuros alquenilos. La reacción es simple, se lleva a cabo bajo condiciones muy suaves y demuestra una amplia tolerancia a grupos funcionales. Además, se desarrolló un protocolo en flujo para permitir una ampliación eficiente de la síntesis de tiocianatos alquenilos, mejorando aún más la practicidad y el valor del método. Es importante destacar que estos tiocianatos alquenilos sirven como valiosos bloques de construcción para la construcción de diversas familias de moléculas que contienen azufre a través de trifluorometilaciones, cicloadiciones, oxidaciones y reacciones de formación de enlaces C–S o P–S., Se agradece sinceramente la beca predoctoral “Severo Ochoa” (BP21/050) concedida a H. F. P. por FICYT (Principado de Asturias) y la beca postdoctoral “Ramón y Cajal” concedida a M. P. (MCINN-24-RYC2022-035485-I) por el Ministerio de Ciencia e Innovación de España (Agencia Estatal de Investigación). También se agradece el apoyo financiero de este trabajo por parte del Ministerio de Ciencia e Innovación de España (Agencia Estatal de Investigación: MCINN-23-PID2022-140635NB-I00/MCIN/AEI/10.13039/501100011033/FEDER, UE) y la Universidad de Oviedo (PAPI-23-GR-COM-04).

Supplementary information for the article "Photochemical carboborylation and three- component difunctionalization of a,b-unsaturated ketones with boronic acids via tosylhydrazones" Chemical Science: DOI: 10.1039/d4sc06537. The data are contained in a word .docx file with the chemdraw and NMR data embebed. NMR data in mestrenova format can be retrieved from the file. NMR data for each compound in Bruker format., Supplementary information for the article "Photochemical carboborylation and three- component difunctionalization of a,b-unsaturated ketones with boronic acids via tosylhydrazones" Chemical Science: DOI: 10.1039/d4sc06537. The ChemDraw structures and the NMR data are embebed in the .docx file. NMR data can be retrieved in mestrenova format., Financial support of this work by Ministerio de Ciencia e Innovación of Spain (Agencia Estatal de Investigación: grant MCINN-23-PID2022-140635NB-I00 Financed by MCIN/AEI/ 10.13039/501100011033/FEDER, UE). A FPI predoctoral contract to A.V.-M. (MCINN-24-PREP2022-000214) and a “Ramón y Cajal” postdoctoral grant to M. P. (MCINN-24-RYC2022-035485-I) by Ministerio de Ciencia e Innovación of Spain (Agencia Estatal de Investigación) are gratefully acknowledged

Data Documentation for “A general sizing methodology of grid-connected PV systems to meet the zero-energy goal in buildings”, This research has received national funds from the Spain Ministry of Universities, through the FPU program (FPU21/05062).

Dataset asociado a la publicación: "Numerical model for determining the effective heat capacity of macroencapsulated PCM for building applications", This work was supported by the Spain Ministry of Universities (FPU21/05062); the Spain Ministry of Science and Innovation through Research Projects PID2021-128056OA-I00 and RED2022-134219-T; and Foundation for the Promotion in Asturias of Applied Scientific Research and Technology through project SV-PA-21-AYUD 2021 51328.

Se presenta la síntesis fotoquímica de sulfonas vinílicas y 1,3-dienílicas basada en radicales y sin el uso de catalizadores. Las investigaciones mecanísticas respaldan que las transformaciones dependen de una activación promovida por luz visible de un complejo de enlace halógeno, formado entre un bromuro alquenilo (o 1,3-dienilo) y una sal de sulfinato de sodio. Las reacciones muestran una amplia tolerancia a grupos funcionales (compatibles con heteroátomos, grupos electroatrayentes y donadores de electrones), encontrando aplicación en la modificación estructural de moléculas de relevancia biológica. Finalmente, se desarrolló un protocolo en flujo continuo para la ampliación de estas transformaciones., Agradecemos el apoyo financiero a este trabajo mediante una beca postdoctoral “Margarita Salas Joven” de FICYT (Principado de Asturias) concedida a M. P. (AYUD/2021/58397), la Universidad de Oviedo (PAPI-23-GR-COM-04) y el Ministerio de Ciencia e Innovación de España (Agencia Estatal de Investigación: PID2019-107580GB-I00/AEI/10.13039/501100011033 y MCINN-23-PID2022-140635NB-I00/MCIN/AEI/10.13039/501100011033/FEDER, UE). También se agradece una beca predoctoral “Severo Ochoa” concedida a H. F. P. (BP21/050) por FICYT (Principado de Asturias).

The study addresses the challenge of detecting cancer-related glycoproteins by targeting abnormal glycosylation patterns. A DNA aptamer (PSA-1), originally selected for the glycan moiety of prostate-specific antigen, is used as a lectin-mimicking receptor. This aptamer was incorporated into an electrochemical sandwich biosensor for detecting serum amyloid P (SAP), a glycoprotein with increased sialylation associated with pancreatic cancer. The biosensor combines an anti-SAP antibody for capture and the PSA-1 aptamer for detection. Two antibody immobilization strategies were compared: protein A-based and boronic ester-based, with the latter reducing nonspecific interactions and improving performance. The optimized platform achieved a detection limit of 6.4 ng/mL in human serum, demonstrated high selectivity against other glycoproteins, and showed potential for generalization to other sialylated biomarkers.

Dataset asociado a la publicación: "A simplified methodology to determine the latent heat of macroencapsulated phase change materials for building envelope applications", This work was supported by the Spain Ministry of Universities (FPU21/05062); the Spain Ministry of Science and Innovation through Research Projects PID2021-128056OA-I00 and RED2022-134219-T; and the Foundation for the Promotion in Asturias of Applied Scientific Research and Technology though project SV-PA-21-AYUD 2021 51328.

This research was funded by the Agencia Estatal de Investigación (AEI) of the Spanish Ministry of Science and Innovation, in the context of the State Program to Promote Scientific–Technical Research and its Transfer, through the Project “Optimization through flow control techniques of a vertical axis wind turbine for urban environments,” included in the Next Generation EU funds of the European Community (TED2021-131307B-I00).

The excel file contains the following tabs: Viability and ROS, Ab concentration optimization, LA-ICP-MS analysis AAPH cells, LA-ICP-MS analysis control cells If any doubt arises when processing it or additional information is needed about the concentrations or measures used, first author/corresponding author should be contacted., This work was financially supported through project Ref. PID2022-137319OB-C21 (funded by MCIN/AEI/10.13039/501100011033/). P. Menero-Valdés acknowledges the FPU Grant with ref. FPU19/00556 (Ministry of Education, Spain).

Data Documentation for the paper titled as “Automatic Debugging of Design Faults in MapReduce applications” published in IEEE Transactions on Software Engineering. Link: https://doi.org/10.1109/TSE.2024.3369766, This work was supported in part by the project PID2019-105455GB-C32 funded by MCIN/AEI/10.13039/501100011033 (Spain), project PID2022-137646OB-C32 funded by MCIN/AEI/10.13039/501100011033/FEDER, UE, and the project RDS_2022-2024_2.1_Progetto_CYBER funded by MASE/PTR_22_24_INT_2_1 (Italy).