Resultados de investigación

JBR was funded by the projects RYC2021–031331-I and PID2022-139422NB-I00, financed by MICIU/ AEI/10.13039/501100011033, FSE+, and the European Union Next Generation EU/PRTR. This work contributes to the Institut de Ciències del Mar "Severo Ochoa Centre of Excellence" accreditation CEX2024-001494-S funded by AEI 10.13039/501100011033 of the Spanish Ministry of Science and Innovation, Peer reviewed

The goal of the ARTEM-IS is to use insights derived from systematic reviews and guidelines for good checklist design to create dynamic and user-friendly web applications which support EEG researchers in creating detailed human- and machine-readable methods summaries. Currently, ARTEM-IS has launched the first of its tools, ARTEM-IS for ERP, which supports describing a simple ERP experiment, including most of its core methodological aspects (study description, experimental design, hardware, data acquisition, pre-processing, measurement, visualisation, additional comments – artemis.incf.org). ARTEM-IS tools for more complex ERP experiments as well as for other subfields of EEG may follow., Peer reviewed

This dataset includes the compositional information of n = 1778 geoarchaeological samples of green phosphate minerals sourced from three major Iberian deposits with evidence of prehistoric mining: Aliste, Terena, and the Gavà Mines. It has been used to develop a data-driven framework that integrates portable X-ray fluorescence (p-XRF) analysis and machine learning (ML), to determine the provenance of archaeological artifacts based on its elemental composition. In addition, a mineralogical analysis by X-ray diffraction (XRD) of a subset (N = 249; n_Aliste = 122, n_Terena = 47, n_Gavà = 80) was conducted to complement the geochemical characterisation of the sample. Data from n = 571 variscite beads from 15 Iberian and French archaeological sites, representing a diverse range of chrono-cultural contexts spanning from the Neolithic to the Bronze Age, used to test the model are also presented. The compositional data was obtained by using a portable XRF analyser and is presented as atomic percentages of the elements between Al and Th. Mineral compositions were determined using a Panalytical X'Pert Pro θ/θ diffractometer. This dataset has high reuse potential for future non-destructive studies of archaeological artefacts and past social network analyses., This work was financed by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia in the framework of the project UID/00698: Centre for Archaeology. University of Lisbon, PhD grant [UI/BD/154365/2023]; The Ministerio de Ciencia e Innovación of the kingdom of Spain, [PID2021–124421NB-I00]; Departament de Cultura de la Generalitat de Catalunya [CLT009/18/00044] and [CLT_2022_EXP_ARQ001SOLC_00000131]., Peer reviewed

Overview illustrating a graphical representation of gating strategy used to detect bone marrow CD34+ hematopoietic progenitor cells (HPC) and plasma cells (PCs) using fluorescence activated cell sorting (BD FACSDiva v 8.0.2). Panels show bivariate dot plots representations in which HPC were gated using conventional manual analysis strategy., Instituto de Salud Carlos III (ISCIII) Cancer Research UK (CRUK) Fundación Científica Asociación Española Contra el Cáncer (AECC) Fondazione AIRC per la ricerca sul cancro ETS (AIRC) Fondazione Regionale per la Ricerca Biomedica (FRRB) International Myeloma Foundation (IMF) HORIZON EUROPE European Research Council (ERC) European Commission (EC) Riney Family Multiple Myeloma Research Program Fund, Peer reviewed

Genetic relationship between mutant HPC and tumor cells. Concordance between the mutational landscape of hematopoietic progenitor cells (HPC) and patient-paired tumor cells (n = 42) used as filtering criteria for mutations observed in RAS genes. All mutated genes in HPC are shown, whereas in tumor cells only the genes that were mutated and were mapped in the myeloid gene panel are shown. Samples were collected at different moments of treatment: in untreated patients (i.e., at diagnosis), after induction, intensification, or end of treatment (EoT). Cytogenetic alterations were determined by FISH during diagnostic procedures. HPC and tumor cell illustrations were created with BioRender.com., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

Overall survival (OS) according to the top four frequently mutated genes at diagnosis: (A) DNMT3A, (B) TET2, (C) ASXL1, and (D) STAG2 in untreated patients enrolled in the GEM2012MENOS65 and GEM- CLARIDEX trials with BM HPC samples., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

Key disease characteristics between patients with available (n = 308) and unavailable (n = 583) samples included and not included in this study from the GEM2012MENOS65, GEM-CESAR, and GEM-CLARIDEX trials. P-value is calculated using corrected χ2 for dichotomous variables, and Kruskal-Wallis for numerical variables., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

List of genes included in the pan-myeloid targeted sequencing panel (SOPHiA GENETICS, Saint Sulpice, Switzerland)., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

Genetic relationship between mutant HPC and tumor cells., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

Project: PRJEB90443; Secondary Study Accession: ERP173445, 26 sites in France and Chile were sampled, including coastal lagoons, fjords, estuaries, harbours, coastal marine sites, and marine offshore sites to investigate the response of microbial communities to environmental disturbances. The communities were identified by 16S rRNA gene metabarcoding (V4-V5; Primers: FWD:GTGYCAGCMGCCGCGGTAA, REV:CCGYCAATTYMTTTRAGTTT) and metagenomic sequencing, Peer reviewed