Resultados de investigación

Scheme containing reactions for FSNs synthesis and functionalization; FTIR analysis of FSNs-EVsA549batch, FSNs-EVsA549micro, and EVsA549; expression of the characteristic EVs-associated membrane markers assembled on the surface of the NPs by Flow Cytometry; super-resolution images obtained on an Elyra 7 (ZEISS) microscope; and biocompatibility test of FSNs and FSNs-APTES on A549 cells and reproducibility of flow cytometry-based uptake yields in the three cell lines., Peer reviewed

Supplementary data 1: Figure S1. Size distribution histogram with Gaussian-fitting curve (solid line) for CuS NPs obtained from TEM images (N=180). The average size was 108 ± 25 nm. Figure S2. TEM images showing BNCs size and morphology. Figure S3. XRD diffractograms of nanogels, CuS NPs functionalized by LbL and BNCs. Figure S4. (a) TGA (black) and derivative of TGA (red) plots for BNC-nanogels. (b) TGA (black) and derivative of TGA (red) plots for CuS NPs functionalized by LbL. Figure S5. Heating curve of water using 808 nm laser at 5.2 W/cm2. Figure S6. Flow cytometry histograms regarding cell apoptosis and cycle obtained from control and CuS@BNC-nanogels samples for the four cell types tested., Peer reviewed

Figure S1: PLGA-RIF calibration; Figure S2: Characterization of the enteric microparticles synthesized in the coaxial microfluidic system with different concentrations of Eudragit., Peer reviewed

Structural characterization data; experimental and simulated MS and EPR spectra; IR spectra with description; magnetostructural data with analysis; excitation and emission spectra; cyclic voltamperograms; calculated log P values; hydrodynamic diameter; and ζ potentials as well as all experimental data., Peer reviewed

Preparation and characterization of NPs, prodye, and prodrug; methods and experimental procedures; biological assays; and Figures S1–S8., Peer reviewed

The SM2 materials is one analysis. It should in all be names as SEM-EDS analysis., Peer reviewed

Screening of exfoliation conditions (dispersion solvent, prewetting solvent, microwave power, microwave irradiation time, MoS2–NMP ratio, and % yield); UV–vis analyses, optical and electronic microscopy analyses; thermogravimetric analysis of bulk and exfoliated MoS2, X-ray photoelectron spectroscopy analysis, electron transport measurements., Peer reviewed

The study was conducted in accordance with the Declaration of Helsinki, and approved by the Human Research Review Committee of the Research Ethics Committee of the Community of Aragon (Comité de Ética de la Investigación de la Comunidad de Aragón, CEICA) ((PI18/198), 04/07/2018).-- Licensed under the terms and conditions of the Creative Commons Attribution (CC BY) license., Table S1: Atomic percentage of EVs isolated from cell cultures. Mean ± SD; Table S2: Nitrogen chemical environmental analysis of EVs isolated from cell cultures. Mean ± SD; Table S3: Percentage atomic composition of EVs isolated from female control donors (n = 6) and ovarian tumor patients of different tumor grades: I (n = 8), II (n = 1), III (n = 2) and IV (n = 7). Mean ± SD; Table S4: Nitrogen composition of EVs isolated from female control donors (n = 6) and ovarian tumor patients of different tumor grades: I (n = 8), II (n = 1), III (n = 2) and IV (n = 7). Mean ± SD; Table S5: Atomic composition of EVs isolated from healthy donors (n = 10) and pancreatic tumor patients (n = 10) at diagnosis. Mean ± SD; Table S6: Nitrogen composition of EVs isolated from healthy donors (n = 10) and pancreatic tumor patients (n = 10) at diagnosis. Mean ± SD., This research was funded by ERC Advanced Grant CADENCE, grant number ERC-2016-ADG-742684”. The research was supported by Instituto de Salud Carlos III (ISCIII) (PI19/01007 and DTS21/00130) and by Fondo Europeo de Desarrollo Regional (Feder) “Una manera de hacer Europa”. We also thank CIBER-BBN, an initiative funded by the VI National R&D&i Plan 2008–2011 financed by the Instituto de Salud Carlos III (ISCIII) with the assistance of the European Regional Development Fund. This study was also partially funded by the Aragon Government (Ph.D. Grant No.r B054/12) and co-funded by Aragon/FEDER 2014–2020 “Building Europe from Aragon”., Peer reviewed

Figure S1: Elemental analysis of CLLCs, Figure S2 d-spacing values of the diffraction pattern shown in Figure 4A2; Table S1. d-spacing values of the diffraction pattern shown in Figure 6A2,B2,C2,D2; Figure S3: Protocol for iron oxide nanoparticle distribution determination; Figure S4: magnetite crystals grown in the bulk (protein free); Figure S5: HR-TEM and SAED of CLLPCs., Peer reviewed

Schematic of the electrochemical cells used; additional data from characterization of materials (SEM and HRTEM images, Raman and XPS spectra, elemental composition, adsorption isotherms, and pore sizes distributions); additional GCD curves; specific charge capacities (using two- and three-electrode setup); and values of the apparent diffusion coefficients., Peer reviewed