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MUSIC SKILLS OF SPANISH-SPEAKING CHILDREN WITH DEVELOPMENTAL LANGUAGE DISORDER. DATA SET.
- Martínez-Castilla, Pastora
- Calet, Nuria
- Jiménez-Fernández, Gracia
EL RECONOCIMIENTO FACIAL ES UN SUPERPODER. CÓMO TE AFECTARÁ Y POR QUÉ DEBERÍAS CONOCERLO
- Pérez y Madrid, Aniceto
2DOF FEEDBACK + FEEDFORWARD SIMULATIONS
- Rodríguez, Carlos
- Aranda-Escolástico, Ernesto
- Guzman, Jose Luis
- Berenguel, Manuel
- Hägglund, Tore
EFFECT OF FERMENTATION AND BAKING ON TROPANE, OPIUM, AND PYRROLIZIDINE ALKALOIDS DURING THE HOMEMADE PREPARATION OF GLUTEN-FREE BREAD WITH POPPY SEEDS AND AROMATIC HERBS
- Vera Baquero, Fernando Leonardo
- Sierra Alonso, Isabel
- Morante Zarcero, Sonia
- Casado Navas, Natalia
- Gañán Aceituno, Judith
MAPPING OF DIGITAL PEDAGOGIES IN HIGHER EDUCATION DATASET
- Santoveña Casal, Sonia
- López, Susana Regina
GELATIN/POLYETHYLENE GLYCOL/G-C3N4 HYDROGEL WITH OLIVE OIL AS A SUSTAINABLE AND BIOCOMPATIBLE NANOVEHICLE FOR TARGETED DELIVERY OF 5-FLUOROURACIL
- Rahmani, Milad
- pourmadadi, mehrab
- Abdouss, Majid
- Rahdar, Abbas
- Diez Pascual, Ana Maria
In this project, a novel, sustainable and pH-sensitive nanocomposite was designed for the targeted delivery of 5-fluorouracil (5-FU) against breast cancer cells. The nanodelivery system is based on graphitic carbon nitride (g-C3N4) coated with Gelatin (G)/Polyethylene glycol (PEG) biopolymers, and was prepared by W/O/W double emulsion technique using olive oil and span 80 surfactant. Successful loading of 5-FU into the nanovehicle was confirmed by infrared spectroscopy and X-ray diffraction analyses.
VDynamic light scattering corroborated the monodispersity of the nanocarriers, with a typical size between 250 and 300 nm. Scanning electron microscopy images revealed the homogeneity of the nanocomposite and its spherical shape. The average zeta potential was +35.4 mV, demonstrating the good stability of the nanocomposite. The drug loading (47%) and encapsulation efficiency (89%) were higher than those reported for other 5-FU nanocarriers.
A continuous and controlled 5-FU release from the nanovehicle was observed, and the release rate at pH 5.4 (simulating a cancerous environment) was higher than at pH 7.4 (physiological conditions). Kinetic studies suggested a diffusion controlled mechanism of 5-FU release from the nanocarrier in an acidic environment, while an anomalous transport prevails at neutral pH. The MTT assay revealed that G/PEG/g-C3N4 had a significant cytotoxicity on MCF-7 breast cancer cells. Flow cytometry indicated that G/PEG/g-C3N4/5-FU led to much higher apoptotic percentage than free 5-FU, while the free drug showed higher percentage of necroptotic cells.
DASOMETRIC DATA OF ROCKROSE (CISTUS LAURIFOLIUS) SAMPLING PLOTS IN FOUR SHRUBLANDS LOCATED IN SORIA (SPAIN)
- Bados Sevillano, Raquel
- Tolosana Esteban, Eduardo
- Esteban Pascual, Luis Saúl
- Fernández Landa, Alfredo
DATA UNESCO HERITAGE CAVES-N SPAIN - DATOS DE RÉPLICA
- Lario, Javier
A THERMODYNAMIC COMPARISON BETWEEN CONVENTIONAL, AUTOTHERMAL, AND SORPTION-ENHANCED BIO-OIL STEAM REFORMING
- MEGIA, Pedro J.
- Rocha, Cláudio
- Vizcaíno, Arturo
- CARRERO, ALICIA
- Calles, Jose A
- Madeira, Luis Miguel
- Soria, Miguel Angel
EXPLORING CEO2-DOPED CO/SBA-15 CATALYSTS FOR ACETIC ACID OXI-DATIVE STEAM REFORMING
- Chirinos Chavez, Carlos Andres
- MORENO DE LA CALLE, Alvaro
- MEGIA, Pedro J.
- Vizcaíno, Arturo
- Calles, Jose A
- CARRERO, ALICIA