Resultados de investigación

La terapia psicológica ha demostrado ser una intervención eficaz. El uso de la metodología basada en los ensayos clínicos aleatorizados (ECA) se ha mostrado esencial a la hora de defender su estatus actual, aunque sus conclusiones pueden verse limitadas por ciertos fenómenos como el abandono de los participantes. Respecto a las variables predictoras más relevantes y consistentes de abandono se encuentra la alianza terapéutica. Objetivo: Nos hemos planteado la realización de una revisión sistemática para investigar y sintetizar la evidencia existente sobre la relación entre alianza terapéutica y el abandono en el contexto de ECA, Metodología: Se realizaron búsquedas en las siguientes bases de datos electrónicas; Psycinfo; Pubmed, Scopus, Cochrane Library, y Web of Science; durante el periodo de los últimos 10 años. Resultados: Se ha obtenido un total de 145 ensayos clínicos aleatorizados seleccionando 10 articulos que cumplían los criterios para su análisis posterior. El número de trabajos ha sido escaso, de baja calidad y elevado riesgo de sesgo, Conclusiones: Se confirma, en general, la relación entre alianza terapéutica y abandono en psicoterapia, sin embargo, esta relación no se detecta en su aplicación en formato online.

El proyecto se desarrolló en Sevilla (España) durante los meses cálidos (abril a octubre) entre 2023 y 2025, con el objetivo de estudiar el confort térmico en espacios urbanos. Se recopilaron 989 observaciones mediante encuestas estructuradas y mediciones ambientales in situ. El conjunto de datos resultante incluye 55 variables agrupadas en tres categorías: variables microclimáticas, características personales, y datos morfológicos del entorno urbano. En un subconjunto se midieron también temperaturas superficiales de distintos materiales urbanos. Estos datos permiten el análisis multivariable de la interacción entre percepción térmica, condiciones ambientales y morfología urbana., Dataset 1 (UTHECA_USE): 989 observaciones con 55 variables de encuesta personal, microclima y morfología urbana. Dataset 2 (UTHECA_USE_additional): 819 mediciones de temperatura superficial sobre diferentes materiales del entorno, relacionadas con las condiciones microclimáticas del primer conjunto.

Optimización de la funcionalización de nanopartículas de venlafaxina para su administración directa al cerebro a través de la ruta nose-to-brain. Los datos se han generado en el marco del proyecto de tesis doctoral de MD Cayero Otero. Los datos aportados son los correspondientes a los ensayos que se corresponden con el diseño y optimización de una formulación conteniendo venlafaxina. Así mismo, se aportan tanto datos sobre posible citotoxicidad de estas en células del neuroepitelio olfativo como estudios in vivo de comportamiento en un modelo animal de depresión para estudiar el tratamiento de la enfermedad a través de la ruta nose-to-brain., Se adjuntan 7 archivos formato de Excel: • Datos correspondientes a los resultados que aparecen en el manuscrito sobre tamaño, distribución de tamaño y potencial Z; así como eficacia de encapsulación y carga de fármaco. • Fig. 2 - Datos correspondientes a la Figura 2 sobre la citotoxicidad de las partículas en la línea celular del neuroepitelio olfativo. • Fig. 4 – Datos correspondientes a la figura 4 sobre los valores cuantitativos de internalización celular (citometría de flujo).

Validation of cannabidiol nanoparticles as a treatment for metabolic syndrome in a hepatic cell model Data Description: This repository contains data from the design and validation trials of a formulation containing cannabidiol. The data also includes results on the potential cytotoxicity of the formulation in an in vitro metabolic syndrome model, as well as cellular assays comparing the formulation's effectiveness against the free cannabinoid, This data set includes a single Excel file (.xlsx). Each tab within the file is named to correspond with the tables and figures from the publication: - Table 1 - Data for Table 1 of the manuscript, which includes information on particle size, size distribution, and Z-potential. - Fig. 2 - Data for Figure 2, on the release profiles obtained for the tested formulations. - Fig. 3 - Data for Figure 3, on the cellular viability of the tested formulations. - Fig. 4 - Data for Figure 4, on glucose uptake after treatment with the formulation. - Fig. 5B - Data for Figure 5, on the quantification of lipid accumulation (ORO) in the in vitro model. - Fig. 6 - Data for Figure 6, on lipid levels in the in vitro model: triglycerides (Fig. 6A), cholesterol (Fig. 6B), and HDL-c (Fig. 6C). - Fig. 7 - Data for Figure 7, on the gene expression levels of targets involved in metabolic syndrome.

Flaxseed fiber-based nanoemulgels have gained significant interest due to their functional and nutritional benefits, promoting the development of healthy, value-added foods. Additionally, they enhance the stability of formulations, leading to increased resistance to phase separation, oxidation, and degradation during storage. This extends the shelf life of the product without the need for artificial preservatives. In this study, the modification of the rheological properties of nanoemulgels O/W mimic the formulation of a salad dressing was evaluated by varying the proportions of microfluidized emulsion and flaxseed gel-like phase in the formulations. Different ratios were analyzed to understand how these variations affect the viscoelasticity, consistency, droplet size, and shelf-life of the systems.

This dataset was generated as a part of a study investigating the mechanisms of bacterial adaptation, with particular emphasis on sequence variability within promoter regions of surface-related genes in Salmonella. The work focused on the opvAB operon, whose transcription is epigenetically regulated through Dam-mediated methylation of GATCs sites and OxyR binding, and plays a key role in Salmonella adaptation under selective pressures such as bacteriophages presence. The dataset, which combines bioinformatic analyses with laboratory experiments, is organized into several files: • BLASTn results: .xlsx file containing alignment information obtained from BLASTn searches using the regulatory sequences (RS) and coding sequences (CDS) of surface-related and housekeeping genes from Salmonella. • G+C content analysis: .dna file containing the sequence of the opvAB operon along with 1.5 kb of upstream and downstream flanking regions. This file enables the identification of the opvAB-containing sequence potentially acquired through horizontal gene transfer by assessing differences in G+C content when compared to the characteristic composition of the Salmonella genome. • Prevalence of opvAB in the genus Salmonella: .xlsx file quantifying the presence of the opvAB operon in Salmonella genomes available in the NCBI database, organized by species (green) and subspecies (purple). • Analysis of regulatory elements diversity across Salmonella enterica subspecies: .xlsx files detailing the conservation of the opvAB promoter's regulatory elements (-35 and -10 boxes, four GATCs and four OxyR Binding Sites [OBSs]) across the enterica, arizonae, diarizonae and salamae subspecies. • Nucleotide composition of OBSs across Salmonella enterica subspecies: .xlsx file showing the percentage of adenine (A), guanine (G), cytosine (C), and thymine (T) nucleotides for each OxyR binding site (OBSs) across the enterica, arizonae, diarizonae and salamae subspecies. • Analysis of mutational distribution within the opvAB regulatory region: .xlsx file reporting the location of mutations in the opvAB promoter across Salmonella enterica subsp. enterica genomes containing up to eight mutations, as well as in environmental strains isolated from poultry farms. Sequence variations are annotated using a numerical code: 0=conserved position, 1=substitution, 2=insertion, and 3=deletion. • Flow Cytometry Data: .lmd files and an associated .xlsx file showing the percentage of cells expressing the opvAB operon (OpvABON)., File name: BLASTn results.xlsx Description: .xlsx file containing alignment information obtained from BLASTn searches using the regulatory sequences (RS) and coding sequences (CDS) of surface-related and housekeeping genes from Salmonella. File name: G+C content analysis.dna Description: .dna file containing the sequence of the opvAB operon along with 1.5 kb of upstream and downstream flanking regions. File name: Prevalence of opvAB in the genus Salmonella.xlsx Description: .xlsx file quantifying the presence of the opvAB operon in Salmonella genomes available in the NCBI database, organized by species (green) and subspecies (purple). File name: Analysis of regulatory elements diversity across Salmonella enterica subspecies.xlsx Description: .xlsx files detailing the conservation of the opvAB promoter's regulatory elements (-35 and -10 boxes, four GATCs and four OxyR Binding Sites [OBSs]) across the enterica, arizonae, diarizonae and salamae subspecies. File name: Nucleotide composition of OBSs across Salmonella enterica subspecies.xlsx Description: .xlsx file showing the percentage of adenine (A), guanine (G), cytosine (C), and thymine (T) nucleotides for each OxyR binding site (OBSs) across the enterica, arizonae, diarizonae and salamae subspecies. File name: Analysis of mutational distribution within the opvAB regulatory region.xlsx Description: .xlsx file reporting the location of mutations in the opvAB promoter across Salmonella enterica subsp. enterica genomes containing up to eight mutations, as well as in environmental strains isolated from poultry farms. Sequence variations are annotated using a numerical code: 0=conserved position, 1=substitution, 2=insertion, and 3=deletion. File name: Percentage of OpvAB-ON cells.xlsx Description: .xlsx file showing the percentage of cells expressing the opvAB operon (OpvABON) obtained from different replicates. File name: Mut. OBS_A.LMD Description: Flow cytometry raw file of the ATCC 14028 strain carrying a mutation in OxyR Binding Site A with an opvB::gfp transcriptional fusion. ile name: Mut. OBS_B.LMD Description: Flow cytometry raw file of the ATCC 14028 strain carrying a mutation in OxyR Binding Site B with an opvB::gfp transcriptional fusion. File name: Mut. OBS_C.LMD Description: Flow cytometry raw file of the ATCC 14028 strain carrying a mutation in OxyR Binding Site C with an opvB::gfp transcriptional fusion. File name: Mut. OBS_D.LMD Description: Flow cytometry raw file of the ATCC 14028 strain carrying a mutation in OxyR Binding Site D with an opvB::gfp transcriptional fusion. File name: Wild type_no GFP.LMD Description: Flow cytometry raw file of the ATCC 14028 wild-type strain without a GFP reporter. File name: opvB_gfp.LMD Description: Flow cytometry raw file of the ATCC 14028 wild-type strain carrying the opvB::gfp transcriptional fusion. File name: SV10095.LMD Description: Flow cytometry raw file of the environmental Salmonella isolate SV10101 carrying opvB::gfp transcriptional fusion. File name: SV10096.LMD Description: Flow cytometry raw file of the environmental Salmonella isolate SV10192 carrying opvB::gfp transcriptional fusion. File name: SV10097.LMD Description: Flow cytometry raw file of the environmental Salmonella isolate SV10193 carrying opvB::gfp transcriptional fusion. File name: SV10098.LMD Description: Flow cytometry raw file of the environmental Salmonella isolate SV10194 carrying opvB::gfp transcriptional fusion. File name: SV10099.LMD Description: Flow cytometry raw file of the environmental Salmonella isolate SV10195 carrying opvB::gfp transcriptional fusion.

Rainfall records collected by gauges lead to key forcings in most hydrological studies. Depending on the type of sensor and recording systems, such data are characterised by different temporal resolutions (or temporal aggregations), ta. We present a historical analysis of the temporal evolution of ta based on a large database of operational rain gauge networks in many study areas. Globally, data were collected from 25,423 rain gauge stations in 32 geographical areas, with major contributions from Australia, USA, Italy and Spain. For very old networks, the first recordings were manual with a coarse temporal resolution, usually daily or sometimes monthly. With some exceptions, mechanical recordings on paper rolls started in the first half of the 20th century, usually with times of 1 h or 30 min. Digital records began only during the last three decades of the 20th century. This short period limits research requiring long time series of sub-daily rainfall data, e.g. analysis of the effects of climate change on short-duration (sub-hourly) intense rainfall. Furthermore, in areas with rainfall data characterised over many years by coarse temporal resolutions, the annual maximum depths of short-duration rainfall can potentially be underestimated and their use would lead to errors in the results.Currently, only 50% of the stations provide useful data at any temporal resolution, which practically means ta = 1 min. However, a significant reduction of these problems can be obtained through the information content of the present database. Finally, we suggest an integration of the database by including additional rain gauge networks to improve its usefulness, particularly in a comparative analysis of the effects of climate change on short duration extreme precipitation available at different locations., Los registros de lluvia recopilados por medidores conducen a forzamientos clave en la mayoría de los estudios hidrológicos. Dependiendo del tipo de sensor y de los sistemas de registro, dichos datos se caracterizan por diferentes resoluciones temporales (o agregaciones temporales), ta. Presentamos un análisis histórico de la evolución temporal de ta basado en una gran base de datos de redes de pluviómetros operativas en muchas áreas de estudio. A nivel mundial, se recopilaron datos de 25.423 estaciones pluviómetros en 32 áreas geográficas, con mayores contribuciones de Australia, EE. UU., Italia y España. Para las redes muy antiguas, las primeras grabaciones eran manuales con una resolución temporal aproximada, normalmente diaria o, a veces, mensual. Con algunas excepciones, los registros mecánicos en rollos de papel comenzaron en la primera mitad del siglo XX, normalmente con tiempos de 1 h o 30 min. Los registros digitales comenzaron sólo durante las últimas tres décadas del siglo XX. Este corto período limita las investigaciones que requieren largas series temporales de datos de precipitaciones subdiarias, por ejemplo, análisis de los efectos del cambio climático en precipitaciones intensas de corta duración (subhorarias). Además, en las áreas con datos de lluvia caracterizados durante muchos años por resoluciones temporales gruesas, las profundidades máximas anuales de lluvia de corta duración pueden potencialmente subestimarse y su uso produciría errores en los resultados de aplicaciones sucesivas. Actualmente, sólo el 50% de las estaciones proporcionan datos útiles en cualquier resolución temporal, lo que prácticamente significa ta = 1 min. Sin embargo, se puede obtener una reducción significativa de estos problemas a través del contenido de información de la presente base de datos. Finalmente, sugerimos una integración de la base de datos mediante la inclusión de redes de pluviómetros adicionales para mejorar su utilidad, particularmente en un análisis comparativo de los efectos del cambio climático sobre las precipitaciones extremas de corta duración disponibles en diferentes ubicaciones., Metadatos de la evolución temporal de tiempo de resolución de los registros pluviométricos (ta) 25.423 estaciones pluviométricas de 32 áreas geográficas diferentes de todo el planeta

The dataset is a SPSS database (.sav) containing scores of university students from Seville and the Basque Country. It collects data related to sociodemographic variables and indicators of Flourishing, Identity, Psychological Distress, and Well-being measured in two cohorts (2015 and 2020, respectively).

Dataset acquired for the study published in the article: “Volatile organic compounds removal by means of a felt-based living wall to improve indoor air quality”. This is part of the project “Fytorremediation of air and water by means of living walls” financed by the Andalusian Plan of Research, development and innovation 2020 (grant number P18-TP-1657) in the 2018 call for Research projects for universities and qualified public research entities as agents of the Andalusian Knowledge System (Junta de Andalucía, Spain). As vegetation can act as a biofilter capturing air pollutants, this study aims to assess the effectiveness of a living wall module in the removal of the Total Volatile Organic Compounds (TVOCs) for IAQ improvement. An airtight glass chamber was used to release contaminants, monitoring the TVOCs both with the chamber empty (control) and with a small Fytotextile® living wall module planted with Nephrolepis exaltata L. A substantial reduction of TVOCs was observed when the living wall was inside the chamber. In few hours, TVOCs levels were reduced below the recommended limit (following Spanish regulations)., Concentrations of volatile organic gases (TVOCs), such as: Hexane; Dichloromethane; Isopropylene; Formaldehyde and Acetone, were used in a closed glass chamber with a vertical garden module planted with Nephrolepis exaltata L. The ability of the plants to reduce the concentration of TVOCs was evaluated.

Dataset acquired for the study published in the article: “Refrigeration capacity and effect of ageing on the operation of cellulose evaporative cooling pads, by wind tunnel analysis”. This work has been funded by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (ERDF) by means of research grant AGL2015-68050-R (Spain). This study investigates the temperature reduction capacity and water consumption of a fan-pad system installed in a greenhouse located in the coastal regions of Almería. The suitability of this system for coastal zones with high environmental humidity during the summer is analyzed. Historical temperature and relative humidity series are studied, obtaining the thermal difference and maximum, medium, and minimum monthly water consumption of the pads based on the operation data of the evaporative cooling pads., Thermal difference, mean water consumption, pressure drop and saturation efficiency of the evaporative cooling pad