Resultados de investigación

MHR: maximum heart rate, HRSD: Hamilton rating scale for depression, PANSS-P: positive and negative syndrome scale (positive subscale), PANSS-G: positive and negative syndrome scale (general subscale), IL-10: interleukin 10, TNF-α: tumor necrosis factor alpha, ROS: reactive oxygen species; ΔΨm: mitochondrial membrane potential, VCAM: vascular cellular adhesion molecule, LEPMN: leukocyte-endothelium adhesion polymorphonuclear, RVPMN: rolling velocity polymorphonuclear cells, PSEL: P-selectin; MPO: myeloperoxidase., Peer reviewed

[Introduction] This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective., [Methods] Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed., [Results] Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p<0.05 to 0.0001; d = 0.47 to 1.63). A better clinical outcomes along with regulation of inflammatory, oxidative, and cardiovascular mechanisms were critical for predicting significant maximum heart rate variation over time (χ2 = 32.2 to 39.0, p < 0.0001)., [Conclusions] The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity., Peer reviewed

All versions are available at DOI 10.6084/m9.figshare.28369472, This repository is a companion to the paper "Evolution in response to an abiotic stress shapes species coexistence", The scripts available allow with the data set provided to replicate all the analyses done in the paper, as well as the figures., Given that running the cxr package requires sometime, we provided the intermediate files used to generate the figure, but we also provide the code done to generate the files, to ensure the total reproducibility analyses., The information is also available at the github repository https://github.com/irfragata/evolution_cadmium_coexistence, For the purpose of Open Access, a CC-BY 4.0 public copyright licence has been applied to the contents of this repository., ERC COMPCON, GA 725419; ERC DYNAMICTRIO, GA 101042392; FCT CEECIND/02616/2018; European Social Fund (CNS2023-144337), Peer reviewed

All versions are available at DOI 10.6084/m9.figshare.28369472, This repository is a companion to the paper "Evolution in response to an abiotic stress shapes species coexistence", The scripts available allow with the data set provided to replicate all the analyses done in the paper, as well as the figures., Given that running the cxr package requires sometime, we provided intermediate files used to generate figures. We also provide the code used to generate the files to ensure the total reproducibility of the analyses., The information is also available at the github repository https://github.com/irfragata/evolution_cadmium_coexistence, For the purpose of Open Access, a CC-BY 4.0 public copyright licence has been applied to the contents of this repository., ERC COMPCON, GA 725419; ERC DYNAMICTRIO, GA 101042392; FCT CEECIND/02616/2018; European Social Fund (CNS2023-144337), Peer reviewed

All versions are available at DOI 10.6084/m9.figshare.28369472, This material is a companion to the paper "Evolution in response to an abiotic stress shapes species coexistence", This information is also available in the git repository: https://github.com/irfragata/evolution_cadmium_coexistence, The scripts available allow with the data set provided to replicate all the analyses done in the paper, as well as the figures., For the purpose of Open Access, a CC-BY 4.0 public copyright licence has been applied to the contents of this repository., ERC COMPCON, GA 725419; ERC DYNAMICTRIO, GA 101042392; FCT CEECIND/02616/2018; European Social Fund (CNS2023-144337), Peer reviewed

This dataset contains 3D assets developed for web-based 3D digital twins. These assets include digital models of oceanographic buoys, scientific instruments, drifters, and Argo floats. Every asset is modeled after real-world equipment and optimized specifically for the web. They feature small file sizes for quick loading times and use standard rendering techniques, allowing them to be rendered without requiring specialized engine or custom shaders. Most models can be quickly visualized in this sketchfab repository. A report is included in the dataset with information about each model and its real-world reference., Peer reviewed

All versions are available at DOI 10.6084/m9.figshare.28369472, This material is a companion to the paper "Evolution in response to an abiotic stress shapes species coexistence", This information is also available in the git repository: https://github.com/irfragata/evolution_cadmium_coexistence, The scripts available allow with the data set provided to replicate all the analyses done in the paper, as well as the figures., For the purpose of Open Access, a CC-BY 4.0 public copyright licence has been applied to the contents of this repository., ERC COMPCON, GA 725419; ERC DYNAMICTRIO, GA 101042392; FCT CEECIND/02616/2018; European Social Fund (CNS2023-144337), Peer reviewed

All versions are available at DOI 10.6084/m9.figshare.28369472, This material is a companion to the paper "Evolution in response to an abiotic stress shapes species coexistence", This information is also available in the git repository: https://github.com/irfragata/evolution_cadmium_coexistence, The scripts available allow with the data set provided to replicate all the analyses done in the paper, as well as the figures., For the purpose of Open Access, a CC-BY 4.0 public copyright licence has been applied to the contents of this repository., ERC COMPCON, GA 725419; ERC DYNAMICTRIO, GA 101042392; FCT CEECIND/02616/2018; European Social Fund (CNS2023-144337), Peer reviewed

All versions are available at DOI 10.6084/m9.figshare.28369472, This material is a companion to the paper "Evolution in response to an abiotic stress shapes species coexistence", This information is also available in the git repository: https://github.com/irfragata/evolution_cadmium_coexistence, The scripts available allow with the data set provided to replicate all the analyses done in the paper, as well as the figures., For the purpose of Open Access, a CC-BY 4.0 public copyright licence has been applied to the contents of this repository., ERC COMPCON, GA 725419; ERC DYNAMICTRIO, GA 101042392; FCT CEECIND/02616/2018; European Social Fund (CNS2023-144337), Peer reviewed

[Introduction] This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective., [Methods] Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed., [Results] Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p<0.05 to 0.0001; d = 0.47 to 1.63). A better clinical outcomes along with regulation of inflammatory, oxidative, and cardiovascular mechanisms were critical for predicting significant maximum heart rate variation over time (χ2 = 32.2 to 39.0, p < 0.0001)., [Conclusions] The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity., Peer reviewed