Resultados de investigación

Dades primàries associades a l'article publicat a Plos Neglected Tropical Diseases, vol. 14, num. 5, p. e0008155 [https://doi.org/10.1371/journal.pntd.0008155], Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma concentrations of a set of thirty-one biomarkers, comprising cytokines, chemokines and growth factors, in 987 plasma samples from a cohort of 572 pregnant women from five malaria-endemic tropical countries and related these concentrations to delivery outcomes (birth weight and hemoglobin levels) and malaria infection. Samples were collected at recruitment (first antenatal visit) and delivery (periphery, cord and placenta), allowing a longitudinal analysis. At recruitment, we found that P. vivax–infected pregnant women had higher plasma concentrations of proinflammatory (IL-6, IL-1β, CCL4, CCL2, CXCL10) and TH1-related cytokines (mainly IL-12) than uninfected women. This biomarker signature was essentially lost at delivery and was not associated with birth weight nor hemoglobin levels. Antiinflammatory cytokines (IL-10) were positively associated with infection and poor delivery outcomes. CCL11 was the only biomarker to show a negative association with P. vivax infection and its concentration at recruitment was positively associated with hemoglobin levels at delivery. Birth weight was negatively associated with peripheral IL-4 levels at delivery. Our multi-biomarker multicenter study is the first comprehensive one to characterize the immunological signature of P. vivax infection in pregnancy thus far. In conclusion, data show that while TH1 and pro-inflammatory responses are dominant during P. vivax infection in pregnancy, antiinflammatory cytokines may compensate excessive inflammation avoiding poor delivery outcomes, and skewness toward a TH2 response may trigger worse delivery outcomes. CCL11, a chemokine largely neglected in the field of malaria, emerges as an important marker of exposure or mediator in this condition.

Dades primàries associades a un article pendent de publicació a la revista PlosOne.

Dades primàries associades a l'article publicat a EClinicalMedicine, vol. 32 [https://doi.org./10.1016/j.eclinm.2020.100720], The trial was conducted in the Pamplona metropolitan area (Navarra, Spain). Patients were enrolled between July 31, 2020 and September 11, 2020 and randomized in a 1:1 ratio to ivermectin (400 mcg/kg) single oral dose or placebo. Assessments on enrollment and at days 4, 7, 14, 21 and 28 post treatment included: general symptoms report, physical examination and adverse events. All patients were asked to complete a daily online diary of symptoms from day 1 to 28 post treatment. On enrollment, as well as on days 7 and 14 blood samples were obtained to assess full blood count, C reactive protein, procalcitonin, ferritin, creatinine phosphokinase, lactic dehydrogenase, troponin T, D dimer, IL-6, and renal function. Viral loads were calculated at enrollment and on days 4, 7, 14 and 21 post treatment based on a nasopharyngeal swab for SARS-CoV-2 PCR (for genes N and E). A semi-quantitative serology for IgG against SARS-CoV-2 was done on samples from all patients on day 21 post-treatment.

Dades primàries associades a l'article publicat a PLoS ONE., Podeu consultar l'article a: http://hdl.handle.net/2445/119909, Datos brutos correspondientes al estudio "The Moral Foundations of Illusory Correlation" (Rodríguez-Ferreiro y Barberia, enviado) incluyendo resultados de cuestionarios de identidad política y moral así como de una tarea de correlación ilusoria.

Dades primàries associades a l'article publicat a BMC Pediatrics, vol. 17 [https://doi.org/10.1186/s12887-017-0816-x], Background: Young children bear the world’s highest prevalence of anaemia, the majority of which is of multifactorial aetiology, which in turn hampers its successful prevention. Even moderate degrees of anaemia are associated with increased mortality and morbidity. Despite this evidence, there is a lack of effective preventive programs and absence of consensus in the safety of iron supplementation in malaria areas, which reflects the poor understanding of the contribution of different aetiologies to anaemia. In order to reduce the anaemia burden in the most vulnerable population, a study to determine the aetiology of anaemia among pre-school Mozambican children was performed. Methods: We undertook a case-control study of 443 preschool hospitalized children with anaemia (haemoglobin concentration <11g/dl) and 289 community controls without anaemia. Inclusion criteria were: age 1-59 months, no blood transfusion in the previous month, residence in the study area and signed informed consent. Both univariable and multivariable logistic regression analyses were performed to identify factors associated with anaemia and adjusted attributable fractions (AAF) were estimated when appropriate. Results: Malaria (adjusted odds ratio (AOR)=8.39, p<0.0001; AAF=37%), underweight (AOR=8.10, p<0.0001; AAF=43%), prealbumin deficiency (AOR=7.11, p<0.0001; AAF=77%), albumin deficiency (AOR=4.29, p=0.0012; AAF=30%), HIV (AOR=5.73, p=0.0060; AAF=18%), and iron deficiency (AOR=4.05, p<0.0001; AAF=53%) were associated with anaemia. Vitamin A deficiency and α-thalassaemia were frequent (69% and 64%, respectively in cases) but not independently related to anaemia. Bacteraemia (odds ratio (OR)=8.49, p=0.004), Parvovirus-B19 (OR=6.05, p=0.017) and Epstein-Barr virus (OR=2.10, p=0.0015) infections were related to anaemia only in the unadjusted analysis. Neither vitamin B12 deficiency nor intestinal parasites were associated with anaemia. Folate deficiency was not observed. Conclusions: Undernutrition, iron deficiency, malaria, and HIV are main factors related to anaemia in hospitalised Mozambican preschool children. Effective programs and strategies for the prevention and management of these conditions need to be reinforced. Specifically, prevention of iron deficiency that accounted in this study for more than half of anaemia cases would have a high impact in reducing the burden of anaemia in children living under similar conditions. However this deficiency, a common preventable and treatable condition, remains neglected by the international public health community.

Dades primàries associades a un article sobre els motius associats a la pràctica d’activitat física, d’acord amb la satisfacció de les necessites bàsiques vinculades a l’esmentada pràctica així com la freqüència de realització de la mateixa., Dades primàries associades a un article publicat a la revista Frontiers in Psychology: https://doi.org/10.3389/fpsyg.2020.621065, Podeu consultar l'article publicat a: http://hdl.handle.net/2445/176635, Raw data from a study about understanding university students’ motives for physical activity (PA), and their relationships with Psychological Need Satisfaction (PNS) and characteristics of practice regularity (frequency, duration, team, competitive, coach, league, federation, and type of day of the week for PA).

Dades associades a un article pendent de publicació a Frontiers in Genetics

Dades primàries associades a l'article publicat a Journal of Clinical Medicine, 2021, vol. 10, num. 18, p. 4223, Raw data from the study “an integrated account of expert perspectives on functioning in schizophrenia”. The document shows individual responses to the last round of the study. the study aims to evaluate the content validity of the ICF-CSs for schizophrenia from the perspective of experts in the treatment of this population, as well as to identify the potential repercussions of this health condition in the functioning of people diagnosed with this disorder. The results provide important support for the worldwide content validity of the ICF-CSs for schizophrenia from the expert perspective and highlight the relevance, in the evaluation and treatment of people with schizophrenia, of assessing functioning by considering the body functions, participation in activities, environmental aspects and personal factors that experts have identified.

Dades primàries associades a un article enviat a la revista PeerJ i pendent d'avaluació (maig 2017), Podeu consultar l'article a: http://hdl.handle.net/2445/115482, Background: Diet deeply affects the food selection and ingestion both in humans and rodents, often resulting in excess energy intake. Methods: We investigated this process comparing two different high-fat dietary approaches to induce obesity, in which all rats received about 40% of their energy intake as lipids. The main nutrient difference between the diets, when compared with controls fed standard lab chow, was the lipid content. Cafeteria diets (K) were devised to be tasty, and thus highly desirable to the rats, mainly for its diverse mix of tastes, particularly salty and sweet. This diet was compared with another high-fat (HF) potentially obesogenic diet, devised not to be as tasty as K, and prepared just supplementing standard chow pellets with fat. We also analysed the influence of sex on the effects of the diets. Results: K rats grew faster, especially the males, although females showed a higher proportion of body lipid, because of a high lipid, sugar and protein intake. HF weight change rates were not different from those of controls. In addition to high sugar, K rats also ingested large amounts of salt. With this study we have shown that the key factor eliciting the excess energy intake in a high-energy diet rat model was not solely or mainly their fat intake. The changes in body fat accrual were more a consequence of their appetence for the food. Conclusions: The results show that the significant presence of sugar and salt is a powerful factor promoting excess food intake, more effective than increasing diet lipid content. These effects were already observed after a relatively short treatment, additionally confirming the differential effects of sex on the hedonic and obesogenic response to diet.

Dades primàries associades a un article publicat a la revista PLoS ONE http://doi.org/10.1371/journal.pone.0184698, Podeu consultar l'article a: http://hdl.handle.net/2445/119911, Dades obtingudes en assajos on es presenta una pista audiovisual associada a un esdeveniment futur ('target') que apareix a la dreta o a l'esquerra de la pantalla, després d'un interval de temps curt o llarg, segons la pista. Els assajos estan codificats de tal manera que es pot saber què ha vist cada particpant en cada un dels assajos (pista E= Elmo / pista G = Big Birg; S = Slow (4 sec interval) / F = Fast (2 sec interval); R = Right (right location) / L = Left (left location). Per tots els participants es va associaciar E/S i G/F. L'associació d'espai (R-L) i temps (S-F) es va contrabalancejar entre els participants. Dades generades amb raw data eye tracking system (Tobii). Els arxius contenen informació de l'edat dels participants per poder separar els dos grups (12 mesos i 15 mesos), codi del participant i una inicial (per a comprovacions internes).