BUSCADOR RECOLECTA

Study of immune correlates against malaria after vaccination with RTS,S/ASO1E: a comphrensive immunological arm of a Phase III double-blind, randomize, controlled multi-centre trial (MAL067)., Dades primàries associades a l'article publicat a NPJ Vaccines, vol. 5 [https://doi.org/10.1038/s41541-020-0192-7], The RTS,S/AS01E vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 26 clinical trial using a 3-dose immunization schedule. A fourth dose 18 months after the primary 27 vaccination was shown to restore the waning efficacy. However, only total IgG against the 28 immunodominant malaria vaccine epitope has been analyzed following the booster. To better 29 characterize the magnitude, nature and longevity of the immune response to the booster, we 30 measured levels of total IgM, IgG and IgG1-4 subclasses against three constructs of the 31 circumsporozoite protein (CSP) and the hepatitis B surface antigen (HBsAg, also present in RTS,S) 32 by quantitative suspension array technology in 50 subjects in the phase 3 trial in Manhiça, 33 Mozambique. To explore the impact of vaccination on naturally acquired immune responses, we 34 measured antibodies to P. falciparum antigens not included in RTS,S. We found increased IgG, 35 IgG1, IgG3 and IgG4, but not IgG2 nor IgM, levels against vaccine antigens one month after the 4th 36 dose. Overall, antibody responses to the booster dose were lower than the initial peak 37 response to primary immunization and children had higher IgG and IgG1 levels than infants. 38 Higher anti-Rh5 IgG and IgG1-4 levels were detected after the booster dose, suggesting that RTS,S 39 partial protection could increase some blood stage antibody responses. Our work shows that the 40 response to the RTS,S/AS01E booster dose is different from the primary vaccine immune 41 response and highlights the dynamic changes in subclass antibody patterns upon the vaccine 42 booster and with acquisition of adaptive immunity to malaria.

The CIMDEF experiment consists on two NW-SE to N-S oriented deep seismic reflection transects and one E-W oriented in the W of Spain. It aimed to sample the Variscan Central Iberian Zone. This transect was designed to be the northward continuation of the ALCUDIA seismic profile, EU - EIT Raw Materials, 17024_20170331_92304. Spanish National Research Program, CGL2014-56548-P; CGL2016-81964-REDE, Peer reviewed

In October 2011, we acquired a 330 km-long and a 430 km-long wide-angle seismic reflection profiles oriented, approximately, EW and NS. Each of the 5 sources consisted of 1Tn of chemical explosives in 2 boreholes and was recorded by 845 digital seismographs with one-component 4.5 Hz geophones (Reftek RF125 IRIS-PASSCAL Texans). The average receiver spacing was 750 m. Shots R1 through R3 where located along the NS line, and R3–R5 were along the EW line. Shot R3 is at the intersection of the two profiles. All shots were recorded by all the stations producing fan shots for 3-D control on deep structure. Up to 402 seismographs were deployed along the EW profile and 443 along the NS profile including 35 in Spain. T, The RIFSIS experiment provided the first well-resolved P-wave velocity crustal models of the Rif Cordillera and its southern continuation toward the Atlas made using controlled-source seismic data. Two 300+ km-long wide-angle reflection profiles crossed the Rif along NS and EW trends. The profiles recorded simultaneously five land explosions of 1Tn each using 850 high frequency seismometers., Ministerio de Ciencia e Innovación. Plan Nacional de Investigación científica, desarrollo e innovación tecnológica, CGL2009–09727; Ministerio de Educación y Ciencia, CGL2006–00041; Comisión Interministerial de Ciencia y Tecnología (CICYT), CGL2008–03474; United Sstates National Science Foundation (NSF), EAR-0808939, No

A high-resolution controlled-source wide-angle reflection seismic experiment was carried out in Morocco in spring 2010. The energy released by six explosions was recorded by 939 Reftek 125a stations (Texans) from the IRIS instrument pool. The location of the shots had an average spacing of 70 km between them. The charge (approximately 1 TM) was distributed in 2–4 boreholes per shot point at depths of 30–60 m., The crustal structure and topography of the Moho boundary beneath the Atlas Mountains of Morocco has been constrained by a controlled source, wide-angle seismic reflection transect: the SIMA experiment (Seismic Imaging of the Moroccan Atlas). It is a high resolution seismic profile acquired from the Sahara craton across the High and the Middle Atlas and the Rif Mountains., Ministerio de Educación y Ciencia, CGL2007–63889, CGL2006–00041; Ministerio de Ciencia e Innovación, CGL2010–15416; Ministerio de Ciencia e Innovación. Plan Nacional de Investigación científica, desarrollo e innovación tecnológica, CGL2009–09727; Comisión Interministerial de Ciencia y Tecnología (CICYT), CGL2008–03474-E; European Science Foundation Eurocores, 07-TOPO_EUROPE_FP-006; United States National Science Foundation (NSF), EAR-0808939, No

IBERSEIS-NI raw data: http://dx.doi.org/10.20350/digitalCSIC/9016 ; http://hdl.handle.net/10261/193954, This is an update of the IBERSEIS Normal Incidence dataset (http://hdl.handle.net/10261/193954). The current version includes the migrated and stack files of the raw data of the IBERSEIS-NI profile., Comisión Interministerial de Ciencia y Tecnología-Fondo Europeo de Desarrollo Regional (CICYT-FEDER), 1FD1997-2179/RYEN1.-- Junta de Andalucía.-- ENRESA.-- Swedish Research Council.-- Instituto Geológico y Minero de España.-- Spanish Ministry of Science and Technology, BTE2000-0583-C02-01, BTE2000-3035-E, BTE2000-1490-C02-01, Peer reviewed