Resultados totales (Incluyendo duplicados): 7
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Encontrada(s) 1 página(s)
CORA.Repositori de Dades de Recerca
doi:10.34810/data1010
Dataset. 2024
COST MOPEIA CLUSTERS DATA
- Abuchahama Saifodine
- Aina Casellas
- Amilcar Nacima
- Baltazar Candrinho
- Binete Savaio
- Carlos Chaccour
- Christen Fornadel
- Eldo Elobolobo
- Francisco Saute
- Jason Richardson
- Joe Wagman
- Molly Robertson
- Rose Zulliger
Data from clusters included in the cross-sectional surveys of COST Mopeia project in 2017
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data106
Dataset. 2022
DATA ON THE EFFECT OF EARLY TREATMENT WITH IVERMECTIN ON VIRAL LOAD, SYMPTOMS AND HUMORAL RESPONSE IN PATIENTS WITH MILD COVID-19.
- Aina Casellas
- Alejandro Fernández Montero
- Andrés Blanco-Di Matteo
- Belen Sadaba
- Carlos Chaccour
- Carlota Dobaño
- Carlota Jordán Iborra
- Ester Laso
- Felix Hammann
- Francisco Carmona Torre
- Gabriel Reina
- Gemma Moncunill
- Iñigo Pineda
- Joe Brew
- José L. Del Pozo
- José R. Yuste
- Mariano Rodríguez Mateos
- Mary-Ann Richardson
- Miriam Fernández Alonso
- Miriam Giráldez
- Paula Ruiz Castillo
- Regina Rabinovich
- Verena Schöning
The trial was conducted in the Pamplona metropolitan area (Navarra, Spain). Patients were enrolled between July 31, 2020 and September 11, 2020 and randomized in a 1:1 ratio to ivermectin (400 mcg/kg) single oral dose or placebo. Assessments on enrollment and at days 4, 7, 14, 21 and 28 post treatment included: general symptoms report, physical examination and adverse events. All patients were asked to complete a daily online diary of symptoms from day 1 to 28 post treatment. On enrollment, as well as on days 7 and 14 blood samples were obtained to assess full blood count, C reactive protein, procalcitonin, ferritin, creatinine phosphokinase, lactic dehydrogenase, troponin T, D dimer, IL-6, and renal function. Viral loads were calculated at enrollment and on days 4, 7, 14 and 21 post treatment based on a nasopharyngeal swab for SARS-CoV-2 PCR (for genes N and E). A semi-quantitative serology for IgG against SARS-CoV-2 was done on samples from all patients on day 21 post-treatment.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data223
Dataset. 2022
EPIDEMIOLOGICAL AND CLINICAL DATA OF OVER 2800 INDIVIDUALS AT RISK FOR TRYPANOSOMA CRUZI INFECTION IN A NON-ENDEMIC COUNTRY
- Aina Casellas
- Alba Abras
- Antonia Calvo-Cano
- Carme Subirà
- Cristina Ballart
- Daniel Camprubí-Ferrer
- Edelweiss Aldasoro
- Elizabeth Posada
- Inés Oliveira-Souto
- Irene Losada-Galván
- Isabel Vera
- Joaquim Gascon
- José Muñoz
- Leonardo de la Torre Ávila
- Maria-Eugenia Valls
- Maria-Jesus Pinazo
- Monsterrat Gállego
- Montserrat Roldán
- Míriam J. Álvarez-Martínez
- Natalia Rodriguez-Valero
- Pedro Laynez-Roldan
- Sergi Sanz
Dataset used for the publication 'Epidemiological profile of over 2800 individuals at risk for Trypanosoma cruzi infection in a non-endemic country. Insights of initial evaluation of cardiac and digestive involvement'
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data592
Dataset. 2023
DEMOGRAPHIC SURVEY
- Paula Ruiz-Castillo
- Saimado Imputiua
- Kexin Xie
- Eldo Elobolobo
- Patricia Nicolas
- Julia Montana
- Edgar Jamisse
- Humberto Munguambe
- Felisbela Materrula
- Aina Casellas
- Xinwei Deng
- Achla Marathe
- Regina Rabinovich
- Francisco Saute
- Carlos Chaccour
- Charfudin Sacoor
Data corresponding to a demographic survey conducted in Mopeia district (Zambezia province, Mozambique) to inform the Broad One Health Endectocide-based Malaria Intervention in Africa project, a cluster randomized clinical trial. Data consists of household and individual level variables.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data682
Dataset. 2023
WEALTH INDEX DATA
- Achla Marathe
- Aina Casellas
- Carlos Chaccour
- Cassidy Rist
- Charfudin Sacoor
- Edgar Jamisse
- Eldo Elobolobo
- Felisbela Materrula
- Francisco Saute
- Humberto Munguambe
- Julia Montana
- Kexin Xie
- Mussa Sale
- Patricia Nicolas
- Paula Ruiz-Castillo
- Regina Rabinovich
- Saimado Imputiua
- Victor Mutepa
- Xinwei Deng
Data corresponding to household socioeconomic characteristics collected in a demographic survey conducted in Mopeia district (Zambezia province, Mozambique).
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data745
Dataset. 2023
SNAKEBITE DATA
- Aina Casellas
- Carlos Chaccour
- Charfudin Sacoor
- Edgar Jamisse
- Eldo Elobolobo
- Emma O'Bryan
- Francisco Saute
- Humberto Munguambe
- Julia Montana
- Patricia Nicolas
- Paula Ruiz-Castillo
- Regina Rabinovich
- Saimado Imputiua
Data corresponding to snakebite characteristics collected in a demographic survey conducted in Mopeia district (Zambezia province, Mozambique).
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data86
Dataset. 2022
CYTOKINE SIGNATURES OF PLASMODIUM VIVAX INFECTION DURING PREGNANCY AND DELIVERY OUTCOMES (RAW DATA)
- Adriana Malheiros
- Aina Casellas
- Anna Rosanas Urgell
- Azucena Bardají
- Camila Botto Menezes
- Carlo Severini
- Carlota Dobaño
- Chetan E. Chitnis
- Clara Menéndez
- Dhiraj Hans
- Flor E. Martínez Espinosa
- Holger Werner Unger
- Ivo Mueller
- Maria Eugenia Castellanos
- Maria Ome-Kaius
- Meghna Desai
- Michela Menegon
- Myriam Arévalo Herrera
- Norma Padilla
- Pilar Requena
- Sanjay K. Kochar
- Stephen John Rogerson
- Swati Kochar
Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma concentrations of a set of thirty-one biomarkers, comprising cytokines, chemokines and growth factors, in 987 plasma samples from a cohort of 572 pregnant women from five malaria-endemic tropical countries and related these concentrations to delivery outcomes (birth weight and hemoglobin levels) and malaria infection. Samples were collected at recruitment (first antenatal visit) and delivery (periphery, cord and placenta), allowing a longitudinal analysis. At recruitment, we found that P. vivax–infected pregnant women had higher plasma concentrations of proinflammatory (IL-6, IL-1β, CCL4, CCL2, CXCL10) and TH1-related cytokines (mainly IL-12) than uninfected women. This biomarker signature was essentially lost at delivery and was not associated with birth weight nor hemoglobin levels. Antiinflammatory cytokines (IL-10) were positively associated with infection and poor delivery outcomes. CCL11 was the only biomarker to show a negative association with P. vivax infection and its concentration at recruitment was positively associated with hemoglobin levels at delivery. Birth weight was negatively associated with peripheral IL-4 levels at delivery. Our multi-biomarker multicenter study is the first comprehensive one to characterize the immunological signature of P. vivax infection in pregnancy thus far. In conclusion, data show that while TH1 and pro-inflammatory responses are dominant during P. vivax infection in pregnancy, antiinflammatory cytokines may compensate excessive inflammation avoiding poor delivery outcomes, and skewness toward a TH2 response may trigger worse delivery outcomes. CCL11, a chemokine largely neglected in the field of malaria, emerges as an important marker of exposure or mediator in this condition.
Proyecto: //
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