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Dades primàries associades a un article publicat a la revista PeerJ https://doi.org/10.7717/peerj.5440

Dades primàries associades a un article enviat a la revista PeerJ i pendent d'avaluació (Abril 2016), Podeu consultar l'article a: http://hdl.handle.net/2445/101599, Dades experimentals de la recerca on s'ha provat de veure si l'administració d'una dieta hiperlipídics (dieta de cafeteria) a rates mascles durant 30 dies, modifica la distribució del fluxs de sang entre els diferents teixits. Això s'ha fet mitjançant l'administració de microesferes fluorescents. S'ha pogut comprobar que hi ha un augment de flux cap el teixit adipós marró, pulmons i cor i una disminució cap a la pell. Això confirma l'augmenten en els teixits que controlen l'energia disipada.

Dades primàries associades a un article publicat a la revista PeerJ disponible a l'adreça http://dx.doi.org/10.7717/peerj.2725, Podeu consultar l'article a: http://hdl.handle.net/2445/104686, Background. White adipose tissue (WAT) is a complex, diffuse, multifunctional organ which contains adipocytes, and a large proportion of fat, but also other cell types, active in defence, regeneration and signalling functions. Studies with adipocytes often require their isolation from WAT by breaking up the matrix of collagen fibres, however, it is unclear to what extent adipocyte number in primary cultures correlates with their number in intact WAT, since recovery and viability are often unknown. Experimental design. Epididymal WAT of 4-6 young adult rats was used to isolate adipocytes with collagenase. Careful recording of lipid content of tissue, and all fraction volumes and weights, allowed us to trace the amount of initial WAT fat remaining in the cell preparation. Functionality was estimated by incubation with glucose and measurement of lactate, glycerol and NEFA production. Non-adipocyte cells were also recovered and their sizes (and those of adipocytes) were also measured. The presence of non-nucleated cells (erythrocytes) was also estimated. Results. Cell numbers and sizes were correlated from all fractions to intact WAT. Tracing the lipid content, the recovery of adipocytes in the final, metabolically active, preparation was in the range of 70-75%. Adipocytes were 7%, erythrocytes 68% and other stromal (nucleated cells) 24% of total WAT cells. However, their overall volumes were, 91%, 0.05%, and 0.2% of WAT. Non-fat volume of adipocytes was 2.5% of WAT. Conclusions. The methodology presented here allows for a direct quantitative reference to the original tissue of studies using isolated cells. We have found, also, that the "live cell mass" of adipose tissue is very small (about 25 µL/g for adipocytes and 2 µL/g stromal, plus about 1 µL/g blood). This fact, translates (with respect to the actual "live cytoplasm" size) into an extremely high metabolic activity, which make WAT an even more significant agent in the control of energy metabolism.

Dades primàries associades a l'article publicat a Journal of Clinical Medicine, 2021, vol. 10, num. 18, p. 4223, Raw data from the study “an integrated account of expert perspectives on functioning in schizophrenia”. The document shows individual responses to the last round of the study. the study aims to evaluate the content validity of the ICF-CSs for schizophrenia from the perspective of experts in the treatment of this population, as well as to identify the potential repercussions of this health condition in the functioning of people diagnosed with this disorder. The results provide important support for the worldwide content validity of the ICF-CSs for schizophrenia from the expert perspective and highlight the relevance, in the evaluation and treatment of people with schizophrenia, of assessing functioning by considering the body functions, participation in activities, environmental aspects and personal factors that experts have identified.

Dades primàries associades a un article sotmès per publicació a la revista PLOS ONE, Raw data from the study Functioning in Schizophrenia from the Perspective of Psychologists: A Worldwide Study. The study aimed to explore the content validity of the International Classification of Functioning, Disability and Health (ICF) Core Sets for schizophrenia from the perspective of psychologists. The results support the content validity of the ICF Core Sets for schizophrenia from the perspective of psychologists and suggest that they are an appropriate framework for describing functioning and disability in individuals with schizophrenia.