BUSCADOR RECOLECTA

Our work demonstrates that alterations in post-transcriptional gene expression because of miRNAs dysregulation might represent an endogenous mechanism by which insulin response in the subcutaneous fat depot is already affected at middle age. Importantly, caloric restriction could prevent this modulation, demonstrating that certain miRNAs could constitute potential biomarkers of age-related metabolic alterations.

El presente conjunto de datos describe y proporciona acceso a las papeletas manuscritas por Ramón Menéndez Pidal en el archivo de la Historia de la Lengua Española, correspondientes al archivador 1, cajón 18, en el que figura el título: "El español moderno. Hacia el futuro (1914-1937)". La estructura de contenidos permite diferenciar las siguientes secciones:

• Generaciones del 14 y del 27.
• Evolución.
• Las otras lenguas hispánicas.
• Vida internacional.

This research raises the potential use of coordination polymers as new useful materials in two essential research fields, allowing the obtaining of a new multi artificial enzyme with the capacity to inhibit the growth of bacteria resistance. The fine selection of the ligands allows the designs of a new 2D Coordination Polymer (CP), with the formula [Cu2(IBA)2(OH2)4]n·6nH2O, by the combination of Cu(II) as the metal center with a pseudo amino acid (H2IBA =Isophthaloyl bis β-alanine). Quantitative total X-Ray Fluorescence (TXRF) analyses show that the obtained CP can gradually release Cu(II) ions. Additionally, this CP can be nano-processed and transformed into the metal-organic gel (MOG) by using different Cu(II) salts concentrations and the application of ultrasounds. Considering its nanometric dimensions, the slow Cu(II) release and its simple processability, its performance as an artificial enzyme, and its antibacterial ability were explored. The results obtained show the first nano-coordination polymer acting as an artificial multienzyme (peroxidase, catalase, and superoxodismutase) exhibiting antibacterial activity in the presence of hydrogen peroxide, with selective behavior for three bacterium strains (S. spiritovirum, A. faecales, and B. cereus). Indeed, this CP shows a more robust inhibition capacity for Sphingobacterium. Going beyond that, as there are no comfortable and practically clinical tests capable of detecting the presence of Sphingobacteria, the compound can be easily embedded to form moldable gelatin that will facilitate the handling and low-cost commercial kits