BUSCADOR RECOLECTA

Filenames: BEC_SSS___SMOS__BAL_L3__B_YYYYMMDDT120000_0.25d_9d_REP_v1.0.nc YYYYMMDD: central date of 9-day map Documents: Baltic+Salinity_D1.1_RDB_v1r7 Baltic+Salinity_D1.2_DUM_v2r0 Baltic+Salinity_D1.3_ATBD_v2r0, BEC ftp service: We serve netCDF data by means of a secure ftp server. NetCDF files from which the maps were made (and other additional data) can be downloaded from sftp address becftp.icm.csic.es at port 27500. If your browser is sftp compatible you can browse directly from sftp://becftp.icm.csic.es:27500 address. In order to download data you should be registered in our BEC ftp service. Registration is free, you can register just by filling the following form: http://bec.icm.csic.es/bec-ftp-service-registration/ If you need a dedicated ftp client (for instance FileZilla https://filezilla-project.org/) you should use the following configuration: Host: sftp://becftp.icm.csic.es username: your username password: your password Port: 27500, To develop a novel Baltic L3 SSS (Sea Surface Salinity) product from the measurements provided by the SMOS (Soil Moisture and Ocean Salinity) mission and to study the potential benefit of incorporating this SSS product into oceanographic and environmental applications within the Baltic Sea. Data acquisition: Satellite ESA SMOS mission (Soil Moisture and Ocean Salinity). Time coverage 05 February 2011 - 27 December 2019. Time resolution: 9 days. Maps frequency generation: Daily. Spatial coverage: Latitude range: 53.5ºN-68ºN Longitude range: 8ºE-30.5ºE. Spatial resolution: 0.25 degrees. Spatial grid: WGS 84 / Regular longitude-latitude. Sensor Satellite SMOS / MIRAS. Format NetCDF. Climate and Forecast (CF) conventions version: 1.6., Baltic+ Salinity Dynamics European Space Agency under contract 4000126102/18/I-BG, Peer reviewed

Filenames: BEC_SSS___SMOS__BAL_L4__B_YYYYMMDDT120000_0.25d_9d_REP_v1.0.nc YYYYMMDD: Day of the map Documents: Baltic+Salinity_D1.1_RDB_v1r7 Baltic+Salinity_D1.2_DUM_v2r0 Baltic+Salinity_D1.3_ATBD_v2r0, BEC ftp service: We serve netCDF data by means of a secure ftp server. NetCDF files from which the maps were made (and other additional data) can be downloaded from sftp address becftp.icm.csic.es at port 27500. If your browser is sftp compatible you can browse directly from sftp://becftp.icm.csic.es:27500 address. In order to download data you should be registered in our BEC ftp service. Registration is free, you can register just by filling the following form: http://bec.icm.csic.es/bec-ftp-service-registration/ If you need a dedicated ftp client (for instance FileZilla https://filezilla-project.org/) you should use the following configuration: Host: sftp://becftp.icm.csic.es username: your username password: your password Port: 27500, To develop a novel Baltic L4 SSS (Sea Surface Salinity) product from the measurements provided by the SMOS (Soil Moisture and Ocean Salinity) mission merged with SST (Sea Surface Temperature) and to study the potential benefit of incorporating this SSS product into oceanographic and environmental applications within the Baltic Sea. Data acquisition: Satellite ESA SMOS mission (Soil Moisture and Ocean Salinity), ESA CCI SST. Time coverage: 05 February 2011 - 27 December 2019. Time resolution: Daily. Maps frequency generation: Daily. Spatial coverage: Latitude range: 53.5ºN-68ºN Longitude range: 8ºE-30.5ºE. Spatial resolution: 0.05 degrees. Spatial grid: WGS 84 / Regular longitude-latitude. Sensor Satellite SMOS / MIRAS. Format NetCDF. Climate and Forecast (CF) conventions version: 1.6., Baltic+ Salinity Dynamics European Space Agency under contract 4000126102/18/I-BG, Peer reviewed

[Adverse Drug Reactions and CT] The xls file shows relevant information about the treatment with aripiprazole and olanzapine, as well as about their possible adverse effects and the frequency with which they occur. [Genotypes] This is a doc files where It is showm the genotype and phenotype frequencies of the analysed polymorphisms, [Objective] To assess adverse events (AEs) and safety of aripiprazole (ARI) and olanzapine (OLA) treatment. [Conclusions] OLA induced more cardiovascular changes; however, more ADRs were registered to ARI. In addition, some polymorphisms may explain the difference in the incidence of these effects among subjects., European Comission ITN Treatment H2020-MSCA-ITN-721236, Peer reviewed

The data generated or analysed during this study are obtained included in the clinical trial registry name, URL and registration number: TREATMENT-HV; EUDRACT 2018-000744-26; https://eudract.ema. europa.eu/. File1 Adverse events after the treatment with antipsychotics, Short-term treatment with aripiprazole and olanzapine had a significant influence on the metabolic parameters. However, it seems that aripiprazole provokes less severe metabolic changes., European Comission ITN Treatment H2020-MSCA-ITN-721236, Peer reviewed

File 1. This xls files shows the data related to the main charateristics used for the development and validation of the new method as long as the measures for letting assure the repeatability and intermediate precision and accuracy values. The results obtained for the pharmacokinetic parameters are also included in the file File 2 This jpg file shows the product ion spectra and chemical structures of the antipsychotics and their metabolites obtained by collision-induced dissociation (CID) of the indicated precursor ions [M+H]+. The fragmentation patterns of all analytes are indicated by an arrow on their chemical structure of each analyte. The results are presented as the percentage of counts versus Mass-to-Charge (m/z). All mass peaks have been normalized to the most abundant, A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated in human plasma for the simultaneous determination of aripiprazole (ARI) and its metabolite dehydro-aripiprazole (DARI); olanzapine (OLA), risperidone (RIS), paliperidone (PAL), quetiapine (QUE), clozapine (CLO) and caffeine (CAF). CAF is included to the method because it can have an influence on drug metabolism due to competitive inhibition. The above mentioned compounds and their isotope-labeled internal standards were extracted from 200 µL human plasma samples by both, effective phospholipids-eliminating three-step microelution-solid-phase extraction (µ-SPE) and protein precipitation (PPT) for comparison. A combination of formic acid (0.2%)-acetonitrile (pH 3.0; 65:35, v/v) was used as mobile phase and the chromatogram was run under gradient conditions at a flow rate of 0.6 mL/min. Run time lasted 6 min, followed by a re-equilibration time of 3 min. All analytes were monitored by mass spectrometric detection operating in multiple reaction monitoring mode and the method was validated covering the corresponding therapeutic ranges: 0.18-120 ng/mL for ARI, 0.25-80 ng/mL for DARI, 1.00-100 ng/mL for OLA, 0.70-60 ng/mL for RIS, 0.20-30 ng/mL for PAL, 0.50-160 ng/mL for QUE, 0.50-1000 ng/mL for CLO, and finally 1200-3700 ng/mL for CAF. The method was validated based on the recommendations of regulatory agencies through tests of precision, accuracy, extraction recovery, identity confirmation, trueness, matrix effect, process efficiency, stability, selectivity, linearity and carry-over effect fulfilling the guideline requirements. Our µ-SPE method results in the elimination of more than 99% of early eluting and more than 92% of late-eluting phospholipids compared to PPT. Additionally, the method was successfully applied for quantifying ARI and OLA plasma concentrations from healthy volunteers., European Comission ITN Treatment H2020-MSCA-ITN-721236, Peer reviewed

File 1. Demographic characteristics of the volunteers from the aripiprazole study. File 2. Prolactin pharmacokinetic parameters after aripiprazole and ibuprofen administration. This xls file shows the modifications in the prolactin concentrations after the administration of aripiprazole or ibuprofen A It is been shown the prolactin concentrations versus time in women and men treated with aripiprazole compared to ibuprofen File 3 Genotype Matrix. The xls file show the detected genetic polymorphism associated with the effects of aripiprazole File 4 Aripiprazole and dehydro-aripiprazole pharmacokinetic parameters. File 5 The influence of polymorphisms on prolactin concentrations., Aripiprazole treatment in schizophrenic patients was previously associated with lower or normalized prolactin levels. Genetic variants in cytochrome P450 (CYP) (CYP2D6), dopamine receptor (DRD2, DRD3) and serotonin receptor (HTR2A, HTR2C) genes were previously associated with antipsychotic-induced hyperprolactinaemia. Our aim was to evaluate whether aripiprazole affects prolactin secretion and its relationship with pharmacogenetics. Thirty-one healthy volunteers receiving a 10-mg single oral dose of aripiprazole were genotyped for 12 polymorphisms in CYP2D6, DRD2, DRD3, HTR2A and HTR2C genes by qPCR. Aripiprazole and dehydro-aripiprazole plasma concentrations were measured by HPLC-MS/MS. Prolactin concentrations of the 31 volunteers taking aripiprazole and 12 volunteers receiving ibuprofen were determined by ELISA. Prolactin concentrations after ibuprofen intake were considered as control, since it is known to cause no effect. Prolactin concentrations were slightly higher in the aripiprazole group compared to the ibuprofen group. All prolactin pharmacokinetic parameters were higher in females than in males. CYP2D6 poor and intermediate metabolizers had notably higher prolactin Cmax and AUC0-12 than normal and ultrarapid metabolizers. The DRD3 rs6280 polymorphism affected prolactin levels: volunteers carrying Ser/Ser genotype had significantly lower prolactin levels than volunteers carrying the Gly allele. Furthermore, HTR2C rs3813929 C/C homozygotes had significantly lower prolactin levels than T allele carriers. Nevertheless, aripiprazole did increase prolactin levels compared to ibuprofen., European Comission ITN Treatment H2020-MSCA-ITN-721236, Peer reviewed

Filenames: BEC_SSS___SMOS__BLA_L2__A_YYYYMMDDT120000_0.25d_1d_REP_v1.0.nc YYYYMMDD: central date Documents of reference: Olmedo et al, 2021, "New SMOS SSS maps in the framework of the Earth Observationdata For Science and Innovation in the Black Sea", Earth Science System Data journal. BEC ftp service: We serve netCDF data by means of a secure ftp server. NetCDF files from which the maps were made (and other additional data) can be downloaded from sftp address becftp.icm.csic.es at port 27500. If your browser is sftp compatible you can browse directly from sftp://becftp.icm.csic.es:27500 address. In order to download data you should be registered in our BEC ftp service. Registration is free, you can register just by filling the following form: http://bec.icm.csic.es/bec-ftp-service-registration/ If you need a dedicated ftp client (for instance FileZilla https://filezilla-project.org/) you should use the following configuration: Host: sftp://becftp.icm.csic.es username: your username password: your password Port: 27500, Dedicated regional Sea Surface Salinity (SSS) product in the Black Sea. Level 2 ascending satellite overpasses. Data acquisition: Satellite ESA SMOS mission (Soil Moisture and Ocean Salinity). Time coverage 01 February 2011 - 31 December 2020. Time resolution: daily. Maps frequency generation: Daily. Spatial coverage: Latitude range: 39ºN-48ºN Longitude range: 26ºE-42ºE. Spatial resolution: 0.25 degrees. Spatial grid: WGS 84 / Regular longitude-latitude. Sensor Satellite SMOS / MIRAS. Format NetCDF. Climate and Forecast (CF) conventions version: 1.6., Peer reviewed

Filenames: BEC_SSS___SMOS__BLA_L2__D_YYYYMMDDT120000_0.25d_1d_REP_v1.0.nc YYYYMMDD: central date Documents of reference: Olmedo et al, 2021, "New SMOS SSS maps in the framework of the Earth Observationdata For Science and Innovation in the Black Sea", Earth Science System Data journal. BEC ftp service: We serve netCDF data by means of a secure ftp server. NetCDF files from which the maps were made (and other additional data) can be downloaded from sftp address becftp.icm.csic.es at port 27500. If your browser is sftp compatible you can browse directly from sftp://becftp.icm.csic.es:27500 address. In order to download data you should be registered in our BEC ftp service. Registration is free, you can register just by filling the following form: http://bec.icm.csic.es/bec-ftp-service-registration/ If you need a dedicated ftp client (for instance FileZilla https://filezilla-project.org/) you should use the following configuration: Host: sftp://becftp.icm.csic.es username: your username password: your password Port: 27500, Dedicated regional Sea Surface Salinity (SSS) product in the Black Sea. Level 2 descending satellite overpasses. Data acquisition: Satellite ESA SMOS mission (Soil Moisture and Ocean Salinity). Time coverage 01 February 2011 - 31 December 2020. Time resolution: daily. Maps frequency generation: Daily. Spatial coverage: Latitude range: 39ºN-48ºN Longitude range: 26ºE-42ºE. Spatial resolution: 0.25 degrees. Spatial grid: WGS 84 / Regular longitude-latitude. Sensor Satellite SMOS / MIRAS. Format NetCDF. Climate and Forecast (CF) conventions version: 1.6., Peer reviewed

Filenames: BEC_SSS___SMOS__BLA_L3__B_YYYYMMDDT120000_0.25d_9d_REP_v1.0.nc YYYYMMDD: central date Documents of reference: Olmedo et al, 2021, "New SMOS SSS maps in the framework of the Earth Observationdata For Science and Innovation in the Black Sea", Earth Science System Data journal. BEC ftp service: We serve netCDF data by means of a secure ftp server. NetCDF files from which the maps were made (and other additional data) can be downloaded from sftp address becftp.icm.csic.es at port 27500. If your browser is sftp compatible you can browse directly from sftp://becftp.icm.csic.es:27500 address. In order to download data you should be registered in our BEC ftp service. Registration is free, you can register just by filling the following form: http://bec.icm.csic.es/bec-ftp-service-registration/ If you need a dedicated ftp client (for instance FileZilla https://filezilla-project.org/) you should use the following configuration: Host: sftp://becftp.icm.csic.es username: your username password: your password Port: 27500, Dedicated regional Sea Surface Salinity (SSS) product in the Black Sea. Level 3 9-day maps. Data acquisition: Satellite ESA SMOS mission (Soil Moisture and Ocean Salinity). Time coverage 01 February 2011 - 31 December 2020. Time resolution: 9-day. Maps frequency generation: Daily. Spatial coverage: Latitude range: 39ºN-48ºN Longitude range: 26ºE-42ºE. Spatial resolution: 0.25 degrees. Spatial grid: WGS 84 / Regular longitude-latitude. Sensor Satellite SMOS / MIRAS. Format NetCDF. Climate and Forecast (CF) conventions version: 1.6., Peer reviewed

Filenames: BEC_SSS___SMOS__BLA_L4__B_YYYYMMDDT120000_0.05d_1d_REP_v1.0.nc YYYYMMDD: central date Documents of reference: Olmedo et al, 2021, "New SMOS SSS maps in the framework of the Earth Observationdata For Science and Innovation in the Black Sea", Earth Science System Data journal. BEC ftp service: We serve netCDF data by means of a secure ftp server. NetCDF files from which the maps were made (and other additional data) can be downloaded from sftp address becftp.icm.csic.es at port 27500. If your browser is sftp compatible you can browse directly from sftp://becftp.icm.csic.es:27500 address. In order to download data you should be registered in our BEC ftp service. Registration is free, you can register just by filling the following form: http://bec.icm.csic.es/bec-ftp-service-registration/ If you need a dedicated ftp client (for instance FileZilla https://filezilla-project.org/) you should use the following configuration: Host: sftp://becftp.icm.csic.es username: your username password: your password Port: 27500, Dedicated regional Sea Surface Salinity (SSS) product in the Black Sea. Level 4 daily maps. Data acquisition: Satellite ESA SMOS mission (Soil Moisture and Ocean Salinity). Time coverage 01 February 2011 - 31 December 2019. Time resolution: daily. Maps frequency generation: Daily. Spatial coverage: Latitude range: 39ºN-48ºN Longitude range: 26ºE-42ºE. Spatial resolution: 0.05 degrees. Spatial grid: WGS 84 / Regular longitude-latitude. Sensor Satellite SMOS / MIRAS. Format NetCDF. Climate and Forecast (CF) conventions version: 1.6., Peer reviewed