BUSCADOR RECOLECTA

Study of immune correlates against malaria after vaccination with RTS,S/ASO1E: a comphrensive immunological arm of a Phase III double-blind, randomize, controlled multi-centre trial (MAL067)., Dades primàries associades a l'article publicat a NPJ Vaccines, vol. 5 [https://doi.org/10.1038/s41541-020-0192-7], The RTS,S/AS01E vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 26 clinical trial using a 3-dose immunization schedule. A fourth dose 18 months after the primary 27 vaccination was shown to restore the waning efficacy. However, only total IgG against the 28 immunodominant malaria vaccine epitope has been analyzed following the booster. To better 29 characterize the magnitude, nature and longevity of the immune response to the booster, we 30 measured levels of total IgM, IgG and IgG1-4 subclasses against three constructs of the 31 circumsporozoite protein (CSP) and the hepatitis B surface antigen (HBsAg, also present in RTS,S) 32 by quantitative suspension array technology in 50 subjects in the phase 3 trial in Manhiça, 33 Mozambique. To explore the impact of vaccination on naturally acquired immune responses, we 34 measured antibodies to P. falciparum antigens not included in RTS,S. We found increased IgG, 35 IgG1, IgG3 and IgG4, but not IgG2 nor IgM, levels against vaccine antigens one month after the 4th 36 dose. Overall, antibody responses to the booster dose were lower than the initial peak 37 response to primary immunization and children had higher IgG and IgG1 levels than infants. 38 Higher anti-Rh5 IgG and IgG1-4 levels were detected after the booster dose, suggesting that RTS,S 39 partial protection could increase some blood stage antibody responses. Our work shows that the 40 response to the RTS,S/AS01E booster dose is different from the primary vaccine immune 41 response and highlights the dynamic changes in subclass antibody patterns upon the vaccine 42 booster and with acquisition of adaptive immunity to malaria.

Dades primàries associades a l'article publicat a Journal of Clinical Medicine, 2021, vol. 10, num. 18, p. 4223, Raw data from the study “an integrated account of expert perspectives on functioning in schizophrenia”. The document shows individual responses to the last round of the study. the study aims to evaluate the content validity of the ICF-CSs for schizophrenia from the perspective of experts in the treatment of this population, as well as to identify the potential repercussions of this health condition in the functioning of people diagnosed with this disorder. The results provide important support for the worldwide content validity of the ICF-CSs for schizophrenia from the expert perspective and highlight the relevance, in the evaluation and treatment of people with schizophrenia, of assessing functioning by considering the body functions, participation in activities, environmental aspects and personal factors that experts have identified.

Dades primàries associades a un article sotmès per publicació a la revista PLOS ONE, Raw data from the study Functioning in Schizophrenia from the Perspective of Psychologists: A Worldwide Study. The study aimed to explore the content validity of the International Classification of Functioning, Disability and Health (ICF) Core Sets for schizophrenia from the perspective of psychologists. The results support the content validity of the ICF Core Sets for schizophrenia from the perspective of psychologists and suggest that they are an appropriate framework for describing functioning and disability in individuals with schizophrenia.