BUSCADOR RECOLECTA

To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed., Peer reviewed

Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef (GPN) polyprotein of clade B. The majority (92.3%) of the volunteers immunized had a positive specific T cell response at any time postvaccination as detected by gamma interferon (IFN-γ) intracellular cytokine staining (ICS) assay. The CD4(+) T cell responses were predominantly Env directed, whereas the CD8(+) T cell responses were similarly distributed against Env, Gag, and GPN. The proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48). Vaccine-induced CD8(+) T cells to HIV-1 antigens after 1 year were polyfunctional and distributed mainly within the effector memory (TEM) and terminally differentiated effector memory (TEMRA) T cell populations. Antivector T cell responses were mostly induced by CD8(+) T cells, highly polyfunctional, and of TEMRA phenotype. These findings demonstrate that the poxvirus MVA-B vaccine candidate given alone is highly immunogenic, inducing broad, polyfunctional, and long-lasting CD4 and CD8 T cell responses to HIV-1 antigens, with preference for TEM. Thus, on the basis of the immune profile of MVA-B in humans, this immunogen can be considered a promising HIV/AIDS vaccine candidate., Peer reviewed

Música., Hi ha una versió de 1994 i una altra de 1978.

Entrevista., Paco Ibáñez fa un breu repàs a la cançó social. Canta a José Agustín Goytisolo, entre altres. Intervé també Manolo Vázquez Montalbán.

Entrevista., José Agustín Goytisolo recita i parla de la llengua catalana.

Veu.

8 programes especials del programa "Fora d'hores" de Ràdio 4 produït pel "Laboratori de Produccions Sonores de Ficció i Entreteniment" de la Llicenciatura de Comunicació Audiovisual de la UAB, Emesos entre el juny i el setembre de 2011

File "table1.dat" contains the CIG number, and general data for the total CO sample., File "tale4.dat" contains the CIG number, and the velocity integrated 12CO(1-0) intensities, line width and central velocities for galaxies newly observed., File "tale5.dat" contains the CIG number and the molecular gas mass for the total CO sample., We characterize the molecular gas content (ISM cold phase) using CO emission of a redshift-limited subsample of isolated galaxies from the AMIGA (Analysis of the interstellar Medium of Isolated GAlaxies) project in order to provide a comparison sample for studies of galaxies in different environments. We present the ^12^CO(1-0) data for 273 AMIGA galaxies, most of them (n=186) from our own observations with the IRAM 30m and the FCRAO 14m telescopes and the rest from the literature. We constructed a redshift-limited sample containing galaxies with 1500km/s

Inscripción en castellano grabada en una lápida de piedra adherida al muro en la fachada principal del edificio del antiguo ayuntamiento, actual Centro de Salud de Cardenete., CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed

Inscripción latina en letra gótica en relieve que recorre el friso de la reja de la capilla de Pozo. La capilla fue fundada por Juan del Pozo (ⴕ1539). El texto es una exaltación de la Virgen María como madre de Dios, cita de la oración Regina cœli. Presenta algunas peculiaridades gráficas como celi por cœli, letare por laetare, y quen por quem., CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed