BUSCADOR RECOLECTA

To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed., Peer reviewed

Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef (GPN) polyprotein of clade B. The majority (92.3%) of the volunteers immunized had a positive specific T cell response at any time postvaccination as detected by gamma interferon (IFN-γ) intracellular cytokine staining (ICS) assay. The CD4(+) T cell responses were predominantly Env directed, whereas the CD8(+) T cell responses were similarly distributed against Env, Gag, and GPN. The proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48). Vaccine-induced CD8(+) T cells to HIV-1 antigens after 1 year were polyfunctional and distributed mainly within the effector memory (TEM) and terminally differentiated effector memory (TEMRA) T cell populations. Antivector T cell responses were mostly induced by CD8(+) T cells, highly polyfunctional, and of TEMRA phenotype. These findings demonstrate that the poxvirus MVA-B vaccine candidate given alone is highly immunogenic, inducing broad, polyfunctional, and long-lasting CD4 and CD8 T cell responses to HIV-1 antigens, with preference for TEM. Thus, on the basis of the immune profile of MVA-B in humans, this immunogen can be considered a promising HIV/AIDS vaccine candidate., Peer reviewed

En este primer episodio, Santiago de Pablo y Virginia López de Maturana hablan sobre símbolos vascos. Descubriremos cuáles son los más importantes, su historia y la importancia que tienen para nuestra cultura. Además, conoceremos el origen del lauburu con Isabel Mellén y los fondos que atesora la Fundación Sancho el Sabio sobre el rock radical vasco con Ander Gondra. Gracias a Jabi Soto nos adentraremos en el fascinante mundo de los orígenes de la fotografía. ¡Descubre estos temas y mucho más en este primer episodio de El Podcast de Sancho el Sabio!

8 programes especials del programa "Fora d'hores" de Ràdio 4 produït pel "Laboratori de Produccions Sonores de Ficció i Entreteniment" de la Llicenciatura de Comunicació Audiovisual de la UAB, Emesos entre el juny i el setembre de 2011

Datos utilizados en los análisis estadísticos del artículo

Data used for meta-analysis of salvage logging effects on woody plant regeneration. point.id= unique identification number for each data point site.id= unique identification number for each publication (see references in attached file). country= Country where the study site was located .disturbance.type, disturbance.severity, time.disturbance.logging, time.logging.measurement, logging.intensity, forest.leaf.habit, forest.age, regeneration.syndrome, aridity = the effect moderators described in Supporting Information S1 of the paper. response= response variable. yi, vi= mean and variance of Hedge's d (effect sizes). data.origin= position in the publication where the data were obtained (or directly from author)., Funded by grants: RTI2018-096187-J-100 from FEDER/ Ministerio de Ciencia, Innovación y Universidades LRB20/1002 from the British Ecological Society Research Fellowship from the Alexander von Humboldt Foundation

Material complementario del artículo "El uso combinado de Reflectance Transformation Imaging (RTI) y Fotogrametría SfM para la mejora de la visualización y el estudio de elementos patrimoniales deteriorados y de difícil acceso", Additional material of the paper "Combined use of Reflectance Transformation Imaging (RTI) and SfM Photogrammetry to enhance research and visualization of damaged and hard to access Cultural Heritage"

File "table1.dat" contains the CIG number, and general data for the total CO sample., File "tale4.dat" contains the CIG number, and the velocity integrated 12CO(1-0) intensities, line width and central velocities for galaxies newly observed., File "tale5.dat" contains the CIG number and the molecular gas mass for the total CO sample., We characterize the molecular gas content (ISM cold phase) using CO emission of a redshift-limited subsample of isolated galaxies from the AMIGA (Analysis of the interstellar Medium of Isolated GAlaxies) project in order to provide a comparison sample for studies of galaxies in different environments. We present the ^12^CO(1-0) data for 273 AMIGA galaxies, most of them (n=186) from our own observations with the IRAM 30m and the FCRAO 14m telescopes and the rest from the literature. We constructed a redshift-limited sample containing galaxies with 1500km/s

Replication Data for: Modulating the Neural Bases of Political Communications: Political Involvement and Perception of the Economic Situation