BUSCADOR RECOLECTA

To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed., Peer reviewed

Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef (GPN) polyprotein of clade B. The majority (92.3%) of the volunteers immunized had a positive specific T cell response at any time postvaccination as detected by gamma interferon (IFN-γ) intracellular cytokine staining (ICS) assay. The CD4(+) T cell responses were predominantly Env directed, whereas the CD8(+) T cell responses were similarly distributed against Env, Gag, and GPN. The proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48). Vaccine-induced CD8(+) T cells to HIV-1 antigens after 1 year were polyfunctional and distributed mainly within the effector memory (TEM) and terminally differentiated effector memory (TEMRA) T cell populations. Antivector T cell responses were mostly induced by CD8(+) T cells, highly polyfunctional, and of TEMRA phenotype. These findings demonstrate that the poxvirus MVA-B vaccine candidate given alone is highly immunogenic, inducing broad, polyfunctional, and long-lasting CD4 and CD8 T cell responses to HIV-1 antigens, with preference for TEM. Thus, on the basis of the immune profile of MVA-B in humans, this immunogen can be considered a promising HIV/AIDS vaccine candidate., Peer reviewed

Cartel de la exposición celebrada en la sede de la Fundación Sancho el Sabio del 4 al 29 de abril 2011

Cartel de la exposición celebrada en la sede de la Fundación Sancho el Sabio del 15 junio al 15 agosto de 2011

Desde la Navidad hasta el carnaval se suceden una serie de celebraciones propias del invierno. Olentzero y Reyes. San Antón, San Blas y Santa Águeda. Carnavales. El calendario de fiestas de invierno, con sus tradiciones, localismos y personajes marca una de las épocas más descritas e investigadas en la etnología vasca. La exposición que organiza la Fundación Sancho el Sabio en su sede pretende dar a conocer la riqueza de sus fondos documentales

Biblioteca digital de científicos y humanistas valencianos., Digital library of Valencian scientists and humanists.

Mapa de que contiene información de los límites de la Reserva Marina de Cala Ratjada (isla de Mallorca) y de la naturaleza de su fondo: la delimitación de las zonas de roca y de los diferentes tipos de sedimentos, Instituto Español de Oceanografía (IEO); Secretaría General del Mar (SGM), Evaluado

Mapa de que contiene información de los límites de la Reserva Marina de La Isla de la Graciosa e Islotes del Norte de Lanzarote y de la naturaleza de su fondo: la delimitación de las zonas de roca y de los diferentes tipos de sedimentos, Instituto Español de Oceanografía (IEO); Secretaría General del Mar (SGM), Evaluado