BUSCADOR RECOLECTA

We profiled gene expression and alternative splicing of non-neoplastic colon from biopsies of 445 healthy individuals. Here we provide summary statistics listings of BarcUVa-Seq eQTLs and sQTLs (from SUPPA2 and from LeafCutter), and of GTEx v8 transverse colon and sigmoid colon sQLTs (from SUPPA2). Filenames indicate the content of each file: {study}.{analysis}.{method}.

Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. Screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (≤24 months); non-uptake cancer was a cancer in subjects who declined screening. A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs.

We profiled gene expression of non-neoplastic colon from biopsies of 445 healthy individuals, as described in Díez-Obrero, Virginia et al. “Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci.” Cellular and molecular gastroenterology and hepatology vol. 12,1 (2021): 181-197. doi:10.1016/j.jcmgh.2021.02.003. Here we provide eQTL summary statistics for the entire sample size of BarcUVa-Seq data (n=445) as well as its strata by colon anatomic location, i.e. eQTLs from ascending (n=138), transverse (n= 143) and descending (n=164) colon.

Data from a retrospective cohort that included individuals aged 50–69 years who participated in colorectal cancer (CRC) screening in Barcelona from 2010 to 2015, and were followed until 2017 to identify interval CRCs. The positivity rate, and detection rates for advanced polyps and CRC were compared according to ambient temperature, humidity, and quarters of the year. A positive FIT was defined as the detection of ≥20 μg Hb/g in feces. The monthly ambient temperature and humidity were recorded on the day that the FIT was performed. In total, 92.273 FIT results from 53.860 participants were analyzed.