BUSCADOR RECOLECTA

We have previously shown that an HIV vaccine regimen including three doses of HIV-modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B) was safe and elicited moderate and durable (1 year) T-cell and antibody responses in 75% and 95% of HIV-negative volunteers (n = 24), respectively (RISVAC02 study). Here, we describe the long-term durability of vaccine-induced responses and the safety and immunogenicity of an additional MVA-B boost., Peer reviewed

Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning. A recent survey revealed that, of the species tested, the newly described species from the Canary Islands, G. excentricus, is one of the most maitotoxic. The goal of the present study was to characterize MTX-related compounds produced by this species. Initially, lysates of cells from two Canary Island G. excentricus strains VGO791 and VGO792 were partially purified by (i) liquid-liquid partitioning between dichloromethane and aqueous methanol followed by (ii) size-exclusion chromatography. Fractions from chromatographic separation were screened for MTX toxicity using both the neuroblastoma neuro-2a (N2a) cytotoxicity and Ca2+ flux functional assays. Fractions containing MTX activity were analyzed using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) to pinpoint potential MTX analogs. Subsequent non-targeted HRMS analysis permitted the identification of a novel MTX analog, maitotoxin-4 (MTX4, accurate mono-isotopic mass of 3292.4860 Da, as free acid form) in the most toxic fractions. HRMS/MS spectra of MTX4 as well as of MTX are presented. In addition, crude methanolic extracts of five other strains of G. excentricus and 37 other strains representing one Fukuyoa species and ten species, one ribotype and one undetermined strain/species of Gambierdiscus were screened for the presence of MTXs using low resolution tandem mass spectrometry (LRMS/MS). This targeted analysis indicated the original maitotoxin (MTX) was only present in one strain (G. australes S080911_1). Putative maitotoxin-2 (p-MTX2) and maitotoxin-3 (p-MTX3) were identified in several other species, but confirmation was not possible because of the lack of reference material. Maitotoxin-4 was detected in all seven strains of G. excentricus examined, independently of their origin (Brazil, Canary Islands and Caribbean), and not detected in any other species. MTX4 may therefore serve as a biomarker for the highly toxic G. excentricus in the Atlantic area.

Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning. A recent survey revealed that, of the species tested, the newly described species from the Canary Islands, G. excentricus, is one of the most maitotoxic. The goal of the present study was to characterize MTX-related compounds produced by this species. Initially, lysates of cells from two Canary Island G. excentricus strains VGO791 and VGO792 were partially purified by (i) liquid-liquid partitioning between dichloromethane and aqueous methanol followed by (ii) size-exclusion chromatography. Fractions from chromatographic separation were screened for MTX toxicity using both the neuroblastoma neuro-2a (N2a) cytotoxicity and Ca2+ flux functional assays. Fractions containing MTX activity were analyzed using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) to pinpoint potential MTX analogs. Subsequent non-targeted HRMS analysis permitted the identification of a novel MTX analog, maitotoxin-4 (MTX4, accurate mono-isotopic mass of 3292.4860 Da, as free acid form) in the most toxic fractions. HRMS/MS spectra of MTX4 as well as of MTX are presented. In addition, crude methanolic extracts of five other strains of G. excentricus and 37 other strains representing one Fukuyoa species and ten species, one ribotype and one undetermined strain/species of Gambierdiscus were screened for the presence of MTXs using low resolution tandem mass spectrometry (LRMS/MS). This targeted analysis indicated the original maitotoxin (MTX) was only present in one strain (G. australes S080911_1). Putative maitotoxin-2 (p-MTX2) and maitotoxin-3 (p-MTX3) were identified in several other species, but confirmation was not possible because of the lack of reference material. Maitotoxin-4 was detected in all seven strains of G. excentricus examined, independently of their origin (Brazil, Canary Islands and Caribbean), and not detected in any other species. MTX4 may therefore serve as a biomarker for the highly toxic G. excentricus in the Atlantic area.

El Mar del Norte alberga importantes bancos de pesca. Es un ecosistema diverso en el que se producen complejas interacciones en la cadena trófica que han sido objeto de estudio por un grupo de científicos de distintos países entre los que se encuentra Marcos Llope, del Instituto Español de Oceanografía. Con él hablamos en nuestro viaje de hoy.

8 programes especials del programa "Fora d'hores" de Ràdio 4 produït pel "Laboratori de Produccions Sonores de Ficció i Entreteniment" de la Llicenciatura de Comunicació Audiovisual de la UAB., Emèsos entre agost i setembre de 2013., Duració: 003000, 002959, 002959, 002959, 002953, 003000, 002959, 002959.

Grup de recerca Tradumàtica, Entrevista a Ràdiu RAI Sardigna sobre l'aparició del primer traductor automàtic per a la llengua sarda (www.apertium.org).

Emès el divendres 2 de juny de 2017 a les 22:15h, Duració: 001710, En la secció de ciència de 'La tarda de Barcelona', de betevé 91.0 fm, l'Òscar Montero ens explica per què, des del segle XIX, Barcelona ha sigut capdavantera en el control alimentari de la carn pel consum humà. Principalment, va ser a conseqüència de la triquinosi. Malgrat l'avenç de la ciència, la zoonosi amenaça una i altra vegada amb noves malalties. En parlem amb José Manuel Gutiérrez, professor de la UAB i expert en veterinària.

Complementary material of a study which analyzes the influence of bibliometric indicators., This work was supported by the National R&D Plan 2008 (research project Parameterization of citation indicators at a national level according with the ANEP categories [TIN2008-03180-E]).

Suplementary material to the Google Scholar Experiment which attempted at analyzing the possibility of manipulating citation count in Google Scholar and its by-products.

Artículo: "Torres-Salinas, D.; Jiménez-Contreras, E. El efecto Cajal: análisis bibliométrico del Programa Ramón y Cajal en la Universidad de Granada. Revista Española de Documentación Científica, 38(1): e075 (2015). [http://hdl.handle.net/10481/35428]", El Programa de contratación de investigadores Ramón y Cajal ha sido uno de los más importantes a nivel nacional para la incorporación de Recursos de I+D cualificados. Pese a su relevancia hasta el momento no existen estudios que evalúen a nivel institucional el rendimiento de estos investigadores. En este trabajo se presenta una evaluación del rendimiento y la aportación a la producción científica internacional de los contratados Ramón y Cajal (RyC) en la Universidad de Granada (UGR). Para ello en primer lugar se contextualizan a nivel nacional los RyC de la UGR. En segundo lugar se analiza su producción y productividad científica en la Web of Science y se compara con el resto de doctores de la UGR. En tercer lugar se analiza el impacto de los RyC y se compara con los de la UGR en 22 disciplinas científicas. Los resultados ponen de manifiesto que la UGR ha obtenido el 2,73% del total de los RyC nacionales siendo las áreas de Física y Ciencias Biológicas las más beneficiadas. Asimismo se evidencia como el 97% de los RyC han sido contratados tras la finalización de sus contratos, de ellos un 79% se incorporó en la UGR y un 72% ejerce como profesor titular. A nivel de producción los RyC durante el período 2003-2012 han figurado como autores en un 7% de los trabajos citables indexados en la Web of Science de la UGR durante el período de disfrute del contrato. Si además tenemos en cuenta las publicadas tras la finalización de su contrato el porcentaje se eleva al 10%. Asimismo se pone de manifiesto como los RyC tienen una productividad mayor que el resto de doctores de la UGR. En el período 2003-2012 el número de trabajos por año de los RyC durante el período de disfrute del contrato fue de 2,29 artículos al año frente al 0,66 del resto de doctores. Los indicadores de impacto analizados a través en 22 disciplinas también evidencian que los RyC tienen un promedio de citas más elevado, publican en revistas científicas de mayor impacto y suelen superar la media de citación del mundo en 18 disciplinas.