BUSCADOR RECOLECTA

To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed., Peer reviewed

Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef (GPN) polyprotein of clade B. The majority (92.3%) of the volunteers immunized had a positive specific T cell response at any time postvaccination as detected by gamma interferon (IFN-γ) intracellular cytokine staining (ICS) assay. The CD4(+) T cell responses were predominantly Env directed, whereas the CD8(+) T cell responses were similarly distributed against Env, Gag, and GPN. The proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48). Vaccine-induced CD8(+) T cells to HIV-1 antigens after 1 year were polyfunctional and distributed mainly within the effector memory (TEM) and terminally differentiated effector memory (TEMRA) T cell populations. Antivector T cell responses were mostly induced by CD8(+) T cells, highly polyfunctional, and of TEMRA phenotype. These findings demonstrate that the poxvirus MVA-B vaccine candidate given alone is highly immunogenic, inducing broad, polyfunctional, and long-lasting CD4 and CD8 T cell responses to HIV-1 antigens, with preference for TEM. Thus, on the basis of the immune profile of MVA-B in humans, this immunogen can be considered a promising HIV/AIDS vaccine candidate., Peer reviewed

8 programes especials del programa "Fora d'hores" de Ràdio 4 produït pel "Laboratori de Produccions Sonores de Ficció i Entreteniment" de la Llicenciatura de Comunicació Audiovisual de la UAB, Emesos entre el juny i el setembre de 2011

8 programes especials del programa "Fora d'hores" de Ràdio 4 produït pel "Laboratori de Produccions Sonores de Ficció i Entreteniment" de la Llicenciatura de Comunicació Audiovisual de la UAB., Emèsos entre agost i setembre de 2013., Duració: 003000, 002959, 002959, 002959, 002953, 003000, 002959, 002959.

Compilación bibliográfica de datos de tasa metabólica basal, tasa metabólica de campo, productividad, duración de la vida, tasa de crecimiento poblacional y densidad poblacional en mamíferos. Los nombres de especie han sido actualizados según Fritz et al. (2009).

Data compilation on the different variables needed to stablish the daily offspring production rate (C, number of offspring female-1 day-1) for the organisms considered. In some cases, the offspring production rate was given directly, while in others we used different variables to estimate it. To calculate the daily offspring production rate we compiled data on the number of offspring per reproductive event (offspring/brood column) and number of reproductive events in a year (broods/year).

Código de R utilizado para la solución matemática de ecuaciones logísticas de crecimiento con exponentes polinomiales y logaritmicos

Bibliographic compilation of planktonic larval duration (PLD), rearing temperature and dimensions of decapod larvae

Bibliographic compilation of planktonic larval duration (PLD), rearing temperature and dimensions of cirripedian larvae

Data compilation for planktonic larval duration (PLD), daily offspring production rate (H), geographic range size (GRS), and IBD slope for a variety of benthic marine organisms.