BUSCADOR RECOLECTA

Dades primàries associades a un article acceptat publicat a la revista Scientific Reports https://doi.org/10.1038/s41598-018-34100-8, Palate breadth of South American sea lions (Otaria flavescens), South American fur seals (Arctocephalus australis) and Franciscana dolphins (Pontoporia blainvillei) from Río de la Plata estuary. Stable isotope values (δ13C and δ15N) and standard length of the Franciscana dolphin (Pontoporia blainvillei) and potential prey species off Río de la Plata estuary. δ13C and δ15N: values not corrected for isotopic baseline shifts; δ13Ccor and δ15Ncor: values corrected for isotopic baseline shifts.

Dades primàries associades l'article publicat a Estuarine, Costal and Shelf Science https://doi.org/10.1016/j.ecss.2020.106708, The bone stable oxygen isotope values and the distance of the stranding site from the innermost point of the estuary for thirteen marine mammal species (Otaria flavescens, Arctocephalus australis, Pontoporia blainvillei, Ziphius cavirostris, Phocoena dioptrica, Phocoena spinipinnis, Delphinus delphis, Globicephala melas, Grampus griseus, Lagenodelphis hosei, Orcinus orca, Pseudorca crassidens and Tursiops truncatus) from the Río de la Plata estuary and the adjoining western South Atlantic Ocean. Stable oxygen isotope values (δ18O) are reported relative to the Vienna Standard Mean Oceanic Water (V-SMOW).

Study of immune correlates against malaria after vaccination with RTS,S/ASO1E: a comphrensive immunological arm of a Phase III double-blind, randomize, controlled multi-centre trial (MAL067)., Dades primàries associades a l'article publicat a NPJ Vaccines, vol. 5 [https://doi.org/10.1038/s41541-020-0192-7], The RTS,S/AS01E vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 26 clinical trial using a 3-dose immunization schedule. A fourth dose 18 months after the primary 27 vaccination was shown to restore the waning efficacy. However, only total IgG against the 28 immunodominant malaria vaccine epitope has been analyzed following the booster. To better 29 characterize the magnitude, nature and longevity of the immune response to the booster, we 30 measured levels of total IgM, IgG and IgG1-4 subclasses against three constructs of the 31 circumsporozoite protein (CSP) and the hepatitis B surface antigen (HBsAg, also present in RTS,S) 32 by quantitative suspension array technology in 50 subjects in the phase 3 trial in Manhiça, 33 Mozambique. To explore the impact of vaccination on naturally acquired immune responses, we 34 measured antibodies to P. falciparum antigens not included in RTS,S. We found increased IgG, 35 IgG1, IgG3 and IgG4, but not IgG2 nor IgM, levels against vaccine antigens one month after the 4th 36 dose. Overall, antibody responses to the booster dose were lower than the initial peak 37 response to primary immunization and children had higher IgG and IgG1 levels than infants. 38 Higher anti-Rh5 IgG and IgG1-4 levels were detected after the booster dose, suggesting that RTS,S 39 partial protection could increase some blood stage antibody responses. Our work shows that the 40 response to the RTS,S/AS01E booster dose is different from the primary vaccine immune 41 response and highlights the dynamic changes in subclass antibody patterns upon the vaccine 42 booster and with acquisition of adaptive immunity to malaria.