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Docta Complutense
oai:docta.ucm.es:20.500.14352/91841
Dataset. 2023
HIERARCHICAL HYBRID COATINGS WITH DRUG-ELUTING CAPACITY FOR MG ALLOY BIOMATERIALS
HIERARCHICAL HYBRID COATINGS WITH DRUG-ELUTING CAPACITY FOR MG ALLOY BIOMATERIALS
- Nicolao-Gómez, Ana
- Martínez-Campos, Enrique
- Moreno, Lara
- Rodríguez-Hernández, Juan
- Matykina, Endzhe
A hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable
polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order
to provide a controlled degradation rate and functionality by creating a favorable porous surface
topography for cell adhesion. The inner, ceramic layer formed by plasma electrolytic oxidation (PEO)
has been enriched in bioactive elements (Ca, P, Si). The intermediate PCL layer sealed the defect in
the PEO layer and the outer microporous PCL layer loaded with the appropriate active molecule,
thus providing drug-eluting capacity. Morphological, chemical, and biological characterizations
of the manufactured coatings loaded with ciprofloxacin (CIP) and paracetamol (PAR) have been
carried out. In vitro assays with cell lines relevant for cardiovascular implants and bone prosthesis
(endothelial cells and premyoblasts) showed that the drug-loaded coating allows for cell proliferation
and viability. The study of CIP and PAR cytotoxicity and release rate indicated that the porous PCL
layer does not release concentrations detrimental to the cells. However, complete system assays
revealed that corrosion behavior and increase of the pH negatively affects cell viability. H2 evolution
during corrosion of Mg alloy substrate generates blisters in PCL layer that accelerate the corrosion
locally in crevice microenvironment. A detailed mechanism of the system degradation is disclosed.
The accelerated degradation of the developed system may present interest for its further adaptation
to new cancer therapy strategies.
Proyecto: //
HANDLE: https://hdl.handle.net/20.500.14352/91841
Docta Complutense
oai:docta.ucm.es:20.500.14352/91841
PMID: https://hdl.handle.net/20.500.14352/91841
Docta Complutense
oai:docta.ucm.es:20.500.14352/91841
Ver en: https://hdl.handle.net/20.500.14352/91841
Docta Complutense
oai:docta.ucm.es:20.500.14352/91841
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