BUSCADOR RECOLECTA

We have previously shown that an HIV vaccine regimen including three doses of HIV-modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B) was safe and elicited moderate and durable (1 year) T-cell and antibody responses in 75% and 95% of HIV-negative volunteers (n = 24), respectively (RISVAC02 study). Here, we describe the long-term durability of vaccine-induced responses and the safety and immunogenicity of an additional MVA-B boost., Peer reviewed

To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed., Peer reviewed

Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef (GPN) polyprotein of clade B. The majority (92.3%) of the volunteers immunized had a positive specific T cell response at any time postvaccination as detected by gamma interferon (IFN-γ) intracellular cytokine staining (ICS) assay. The CD4(+) T cell responses were predominantly Env directed, whereas the CD8(+) T cell responses were similarly distributed against Env, Gag, and GPN. The proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48). Vaccine-induced CD8(+) T cells to HIV-1 antigens after 1 year were polyfunctional and distributed mainly within the effector memory (TEM) and terminally differentiated effector memory (TEMRA) T cell populations. Antivector T cell responses were mostly induced by CD8(+) T cells, highly polyfunctional, and of TEMRA phenotype. These findings demonstrate that the poxvirus MVA-B vaccine candidate given alone is highly immunogenic, inducing broad, polyfunctional, and long-lasting CD4 and CD8 T cell responses to HIV-1 antigens, with preference for TEM. Thus, on the basis of the immune profile of MVA-B in humans, this immunogen can be considered a promising HIV/AIDS vaccine candidate., Peer reviewed

Audiovisual sobre el grupo artístico 4 Elementes, autores de Postlibros, Peer reviewed

En este primer episodio, Santiago de Pablo y Virginia López de Maturana hablan sobre símbolos vascos. Descubriremos cuáles son los más importantes, su historia y la importancia que tienen para nuestra cultura. Además, conoceremos el origen del lauburu con Isabel Mellén y los fondos que atesora la Fundación Sancho el Sabio sobre el rock radical vasco con Ander Gondra. Gracias a Jabi Soto nos adentraremos en el fascinante mundo de los orígenes de la fotografía. ¡Descubre estos temas y mucho más en este primer episodio de El Podcast de Sancho el Sabio!

The use of non-invasive methodology, which does not cause damage or alterations on benthic communities, is particularly necessary in vulnerable ecosystem studies and Marine Protected Areas (MPA) monitoring. The European directives on protection and the OSPAR Commission described the habitats structured by sessile species of great size, such as corals or sponges, as particularly vulnerable habitats requiring special protection. The knowledge of population structures as indicators of their state of health is a requirement to improve the management programs. The presence of gorgonian forests and deep-sea sponge aggregations in the Le Danois Bank was the cause of it declaration by the Ministry of the Environment as "El Cachucho” MPA, being included in the Natura 2000 network. Currently being performed follow-up surveys to know their conservation status. This study presents methodology and first results obtained in the analysis of the video transects acquired in ‘El Cachucho’ MPA, during the ESMAREC survey using the ROTV Politolana underwater towed vehicle. Video was recorded to pilot the ROTV, so characteristics of video camera were not specifically designed for monitoring the habitats. But recent developments in specific software of photogrammetric image analysis have allowed extracting valuable information of these video transects. The outputs of the photogrammetric approach include products such as geo-referenced orthomosaic, Digital Surface Model (DSM) and point cloud (XYZ). These data show the possibility to evaluate the size and morphology (including 3D analysis) of the vulnerable species in the area, as the gorgonians Paramuricea placomus and Callogorgia verticillata and the sponges Asconema setubalense and Geodia megastrella. The non-invasive growth rate studies need a set of measurement, fan height, fan width, and others. This methodology will make easier future studies about age and rate of growth of these species and population structure in the zone.

Vídeo conmemorativo, con el personal y la Dirección del IPNA-CSIC, sobre el Día de la Mujer y la Niña en la Ciencia, Peer reviewed

Plano medio, de izquierda a derecha, Javier Bello, alcalde de Alcalá de Henares; Rafael Rodríguez-Ponga Salamanca, secretario general del Instituto Cervantes; y Fernando Galván, rector de la Universidad de Alcalá de Henares (UAH), durante la presentación del programa «Lecturas y relecturas. Lecturas actuales de prosas clásicas» en el Instituto Cervantes en Alcalá de Henares.

Plano medio, en la mesa de izquierda a derecha, Javier Bello, alcalde de Alcalá de Henares; Rafael Rodríguez-Ponga Salamanca, secretario general del Instituto Cervantes; y Fernando Galván, rector de la Universidad de Alcalá de Henares (UAH), durante la presentación del programa «Lecturas y relecturas. Lecturas actuales de prosas clásicas» en la sede del Instituto Cervantes en Alcalá de Henares.

Plano medio de Charles-Étienne Lagasse, presidente de la red de Institutos Culturales Europeos (EUNIC) y director general de Wallonie-Bruxelles International, durante la presentación de proyectos de EUNIC en el Instituto Cervantes.