Resultados de investigación

This article contains data related to the research article entitled “Results of genotype–guided antiplatelet therapy in patients undergone percutaneous coronary intervention with stent” (J. Sánchez-Ramos, C.L. Dávila-Fajardo, P. Toledo Frías, X. Díaz Villamarín, L.J. Martínez-González, S. Martínez Huertas, F. Burillo Gómez, J. Caballero Borrego, A. Bautista Pavés, M.C. Marín Guzmán, J.A. Ramirez Hernández, C. Correa Vilches, J. Cabeza Barrera, 2016) (1). This data article reports, for the first time, about the non-randomized clinical trial protocol that check if CYP2C19/ABCB1 genotype–guided strategy in which the choice of antiplatelet therapy is based on the genetic test, reduces the rates of cardiovascular events and bleeding compared to a non-tailored strategy in patients undergone percutaneous coronary intervention (PCI) with stent. The data included in this article are: design and setting of the study, study population, inclusion and exclusion criteria, definition of the intervention, objectives, variables (baseline characteristics and during the follow-up), study procedures, collection and treatment of the biological sample, genotyping, withdrawal criteria, sample size, statistic analysis, ethical aspects, information sheet and consent form. The authors confirm that this study has been registered in Eudra CT (Eudra CT: 2016-001294-33)., Ministry of Health of Government of Andalusia PI-057/2012

The increasing demand and limited availability of fishmeal (FM) have intensified the need for sustainable alternative protein sources in shrimp aquafeeds. This study evalu-ated high FM replacement in juvenile Penaeus vannamei reared under biofloc technology (BFT), integrating in vitro protein digestibility, growth performance, nutrient utilization and microbiome analyses. Six isoproteic and isolipidic diets combined two FM levels (0% and 7.5%) with animal (A), plant (P), or mixed (AP) protein sources, plus a 15% FM control diet were assayed. Plant based diets showed higher in vitro protein digestibility and amino acid release than animal based diets. However, these differences were not reflected in shrimp growth, as final body weight, SGR and survival were similar among dietary treatments. Apparent feed conversion ratio, protein efficiency, and economic performance were improved in shrimp fed the A7.5 and AP7.5 diets, whereas complete FM replacement resulted in poorer performance. Biofloc and shrimp intestinal microbial community composition was primarily driven by temporal succession, whereas dietary protein source modulated the abundance of specific bacterial families. Biofloc and in-testinal communities shared limited taxonomic overlap at the family level, suggesting restricted microbial exchange together with strong habitat and host mediated selection. Overall, these findings indicate that a diet containing 7.5% fishmeal (FM), supplemented with either animal derived proteins or a combination of animal and plant derived pro-tein sources, represents an optimal strategy for juvenile Penaeus vannamei cultured under BFT conditions, maintaining growth performance while preserving intestinal microbial stability and health., This work was supported by the I+D+i Research Project “Optimizing Shrimp Feeding and Nutrition in Biofloc Systems (BioFlango)” (PID2020-114574RB-C21) and by a predoctoral Research Personnel Training Grant awarded to S. Ferrando-Juan (PRE2021-098367), both funded by MCIN/AEI/10.13039/501100011033. Additionally, J. Gomez-Aguilera contract was supported by European Union Next Generation-Plan of Conselleria d’innovacio, Universitats, Ciencia i Societat Digital of Generalitat Valenciana (INVEST/2022/434). The authors gratefully acknowledge Rubén Olivares Perona, shrimp farm technician and colleague at the Universitat Politècnica de València, for his valuable assistance during initial and final animal sampling.

[EN] The data were used to analyse the correlation between some aspects of the library of the Universitat Politècnica de València (UPV) and the research outputs of the UPV. There are two kinds of data: on the one hand, data of the library of the UPV that was mainly obtained from the statistical data published annually by REBIUN. On the other hand, data of research outputs of the UPV that were obtained by consulting different bibliographic databases such as SCOPUS. Several variables of each kind of data were selected and a correlation analysis was made between different variables of each group.

[EN] Ontological model that categorises dimensions, domains, and types of problems that can affect citizens' quality of life and well-being., Esta ontología es parte del proyecto de I+D+i PID2020-112827GB-I00 financiado por MICIU/AEI/10.13039/501100011033.

[EN] The overall objective of the NEW4ALMOND project is to improve the health status and productivity of almond, through the development of techniques and procedures that allow reducing the impact of the most important diseases of the crop and thus contribute to its management from an economic and environmental point of view. The NEW4ALMOND_SP3_Diaporthe_amygdali_Control dataset includes part of the data obtained in the activities of Subproject 3 developed at the UPV related with improving the knowledge about potential strategies for Diaporthe dieback management.

[EN] This research work studies the development of an electrochemical cell prototype based on textile electrodes for treating wastewater via electrochemical processes. The present prototype proposes a system that offers greater efficiency regarding the size/surface of electrodes in electrolysis processes. This prototype enables the treatment of large volumes of dissolution. Moreover, this prototype could surface modify textile electrodes by an electrochemical process in the same cell, specifically, an electrochemically reduced graphene oxide intermediate layer and an outer layer of electrochemically reduced metal nanoparticles are proposed. Surface modification by reduced graphene oxide increase the textile electrode’s stability, conductivity, and specific surface, whilst Pt nanoparticles increase electroactivity. Amaranth was selected to validate the use of this prototype in treating emerging pollutants. This is an azoic dye with a simple structure. Various analytical techniques demonstrate that colour removal takes place with an electrical energy consumption of between 0.29 and 4.66 kWh m−3 (depending on the operational specifications of the electrolysis performed). Once the colour is removed, total organic carbon and chemical oxygen demand decreases by up to 49% and 37%, respectively., This research is part of the Spanish R+D+i contract (TED2021-130905B-I00 funded by MCIN/ AEI/10.13039/501100011033 and the “European Union NextGenerationEU/PRTR”). The authors wish to acknowledge the Spanish AEI Research Network (Contract RED2022-134552-T). Chemviron Carbon, who kindly donated the FlexzorbTM FM10 activated carbon fabrics and Funding for open access charge CRUE-Universitat Politècnica de València, are acknowledged too. The authors are grateful for the English revision by John Rawlins and Tim Vickers.

The early intestinal response of Mugil cephalus to fishmeal replacement with alternative protein sources under biofloc technology (BFT) was assessed. Juvenile mullet (82.68 ± 0.05 g) were distributed among three dietary treatments with decreasing fishmeal inclusion levels of 15%, 5%, and 0%, corresponding to FM15, FM5, and FM0, respectively. After 27 days of feeding, intestinal samples were analyzed for microbiota composition, transcriptomic responses and enzymatic activity. The FM0 group exhibited reduced intestinal enzyme activity, whereas no significant differences were observed in terms of gut microbiota among the diets. Furthermore, transcriptomic analysis revealed differentially expressed genes associated with enriched GO terms and KEGG pathways related to lipid metabolism. This response was consistent with the lower mesenteric fat indices and whole-body lipid content observed in fish fed the FM0 diet, suggesting an early metabolic adjustment associated with complete fishmeal replacement and the higher dietary protein content. All diets exhibited high protein efficiency ratios (9.98 ± 2.42) and low feed conversion ratios (0.40 ± 0.17), with no significant differences observed among them. However, complete fishmeal replacement negatively affected intestinal physiology and lipid storage, indicating that these alterations were not fully compensated for by the biofloc system and may not be physiologically sustainable over longer periods. Further studies over an extended period could be carried out to evaluate the long-term effects of these diets., This work was supported by Grant TED2021-129272B-C21, funded by MICIU/AEI/10.13039/501100011033, and by the European Union NextGenerationEU/PRTR and the Generalitat Valenciana (GVA AICO/2021/198). J. Brol has a predoctoral grant from Generalitat Valenciana (Programa Santiago Grisolía 2021; CIGRIS/2021/109). R. Olivares-Perona has a technician contract that was funded by TED2021-129272B-C21. Funding for open access charge: Universitat Politècnica de València.

Background and Objective: Assessment of drug cardiotoxicity is critical in the development of new compounds and modeling of drug-binding dynamics to hERG can improve early cardiotoxicity assessment. We previously developed a methodology to generate Markovian models reproducing preferential state-dependent binding properties, trapping dynamics and the onset of IKr block using simple voltage clamp protocols. Here, we test this methodology with real IKr blockers and investigate the impact of drug dynamics on action potential prolongation. Methods: Experiments were performed on HEK cells stably transfected with hERG and using the Nanion SyncroPatch 384i. Three protocols, P-80, P0 and P40, were applied to obtain the experimental data from the drugs and the Markovian models were generated using our pipeline. The corresponding static models were also generated and a modified version of the O´Hara-Rudy action potential model was used to simulate the action potential duration. Results: The experimental Hill plots and the onset of IKr block of ten compounds were obtained using our voltage clamp protocols and the models generated successfully mimicked these experimental data, unlike the CiPA dynamic models. Marked differences in APD prolongation were observed when drug effects were simulated using the dynamic models and the static models. Conclusions: These new dynamic models of ten well-known IKr blockers constitute a validation of our methodology to model dynamic drug–hERG channel interactions and highlight the importance of state-dependent binding, trapping dynamics and the time-course of IKr block to assess drug effects even at the steady-state.

[EN] The benchmarking of security tools is endeavored to determine which tools are more suitable to detect system vulnerabilities or intrusions. The analysis process is usually oversimplified by employing just a single metric out of the large set of those available. Accordingly, the decision may be biased by not considering relevant information provided by neglected metrics. This work proposes a novel approach to take into account several metrics, different scenarios, and the advice of multiple experts. The proposal relies on experts quantifying the relative importance of each pair of metrics towards the requirements of a given scenario. Their judgments are aggregated using group decision making techniques, and pondered according to the familiarity of experts with the metrics and scenario, to compute a set of weights accounting for the relative importance of each metric. Then, weight-based multi-criteria-decision-making techniques can be used to rank the benchmarked tools. This dataset contains raw data obtained from 21 experts, who declared their familiarity with considered metrics and their preference for each metric in the considered scenarios. Processed data include the consistency ratio of resulting pairwise comparison matrices so inconsistent matrices are rejected - weight = 0.00), the relative contribution of each expert according to their declared familiarity with metrics and computed CRs, and the contribution (weight) of each metric towards each considered scenario.