Resultados de investigación

Genetic relationship between mutant HPC and tumor cells. Concordance between the mutational landscape of hematopoietic progenitor cells (HPC) and patient-paired tumor cells (n = 42) used as filtering criteria for mutations observed in RAS genes. All mutated genes in HPC are shown, whereas in tumor cells only the genes that were mutated and were mapped in the myeloid gene panel are shown. Samples were collected at different moments of treatment: in untreated patients (i.e., at diagnosis), after induction, intensification, or end of treatment (EoT). Cytogenetic alterations were determined by FISH during diagnostic procedures. HPC and tumor cell illustrations were created with BioRender.com., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

Overall survival (OS) according to the top four frequently mutated genes at diagnosis: (A) DNMT3A, (B) TET2, (C) ASXL1, and (D) STAG2 in untreated patients enrolled in the GEM2012MENOS65 and GEM- CLARIDEX trials with BM HPC samples., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost-effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision-makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal species based on their sound. Automated sound analyses usually require the training of sound detection and identification algorithms. These algorithms are based on annotated acoustic datasets which mark the occurrence of sounds of species inside sound recordings. However, compiling large annotated acoustic datasets is time-consuming and requires experts, and therefore, they normally cover reduced spatial, temporal, and taxonomic scales. This data paper presents WABAD, the World Annotated Bird Acoustic Dataset for passive acoustic monitoring. WABAD is designed to provide the public, the research community, and conservation managers with a novel and globally representative annotated acoustic dataset. This database includes 5047 min of audio files annotated to species-level by local experts with the start and end time and the upper and lower frequencies of each identified bird vocalization in the recordings. The database has a wide taxonomic and spatial coverage, including information on 91,931 vocalizations from 1192 bird species recorded at 72 recording sites in 29 recording locations (mainly countries) and distributed across 13 biomes. WABAD can be used, for example, for developing and/or validating automatic species detection algorithms, answering ecological questions, such as assessing geographical variations on bird vocalizations, or comparing acoustic diversity indices with species-based diversity indices., Peer reviewed

Key disease characteristics between patients with available (n = 308) and unavailable (n = 583) samples included and not included in this study from the GEM2012MENOS65, GEM-CESAR, and GEM-CLARIDEX trials. P-value is calculated using corrected χ2 for dichotomous variables, and Kruskal-Wallis for numerical variables., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

List of genes included in the pan-myeloid targeted sequencing panel (SOPHiA GENETICS, Saint Sulpice, Switzerland)., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

Genetic relationship between mutant HPC and tumor cells., Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca Biomedica International Myeloma Foundation European Research Council European Commission Multiple Myeloma Research Foundation, Peer reviewed

SV gratefully acknowledges the financial support from EQUALSEA (Transformative adaptation towards ocean equity) project, under the European Horizon 2020 Program, ERC Consolidator (Grant Agreement # 101002784) funded by the European Research Council. He also acknowledges the support of the Earth Commission and Future Earth. AO-A was supported by a Ramon y Cajal grant funded by the Ministry of Science and Innovation (RyC2023-043454-I). This work contributes to the IMEDEA’s ‘Center of Excellence’ Maria de Maetzu (CEX2021-001198). This work contributes to the ICM “Severo Ochoa Centre of Excellence” accreditation (CEX2024-001494-S funded by AEI 10.13039/501100011033, Peer reviewed

Project: PRJEB90443; Secondary Study Accession: ERP173445, 26 sites in France and Chile were sampled, including coastal lagoons, fjords, estuaries, harbours, coastal marine sites, and marine offshore sites to investigate the response of microbial communities to environmental disturbances. The communities were identified by 16S rRNA gene metabarcoding (V4-V5; Primers: FWD:GTGYCAGCMGCCGCGGTAA, REV:CCGYCAATTYMTTTRAGTTT) and metagenomic sequencing, Peer reviewed

Peer reviewed

Distributed Acoustic Sensing acquisition in the Instituto de Astrofisica de Canarias observatories in La Palma and Tenerife to monitor the 2021 Cumbre Vieja eruption in the island of La Palma, Peer reviewed