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Programa de cribado de cáncer colorrectal de la comunidad valenciana: Resultados de la primera ronda: 2005-2008.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Several studies evaluating colorectal cancer (CRC) screening with fecal occult blood testing (FOBT) have reported a significant reduction in mortality from this tumor. The study aims to describe the results of the first round of the CRC screening program in medium-risk population of Valencia and assessing their feasibility and acceptability.



Variabilidad y coste de oportunidad de las alternativas quirúrgicas en cáncer de mama.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

To analyze medical practice variation in breast cancer surgery (either inpatient-based or day-case surgery), by comparing conservative surgery (CS) plus radiotherapy vs. non-conservative surgery (NCS). We also analyzed the opportunity costs associated with CS and NCS.



Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.



Projecte RIU: cambios percibidos por agentes de salud y profesionales tras una intervención en salud en un barrio en situación de vulnerabilidad.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

To describe how health agents and professionals working in a community project perceive the changes related to the population health status and their use of health-care services after the RIU intervention in an urban area of socioeconomic disadvantage.



Quality assurance in cancer. Acceptable delays in deciding the therapeutic plan in breast cancer and colorectal cancer

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background. To determine recommended delays for treatment once there is well-founded clinical suspicion in care processes for breast and colorectal cancer, taking into account resources and the psychological well-being of the patients. Method. A qualitative study among professionals. The study was conducted in two phases. Firstly, during 4 sessions (N=19) we conducted a revision of the care processes of breast cancer and colorectal cancer and fixed desirable times. Secondly, through a…



Suspected adverse events to measles, mumps and rubella vaccine reported to the Community of Valencia Pharmacovigilance Centre

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: A Pharmacovigilance system is an important tool for post-marketing monitoring on vaccine safety. Measles, mumps, rubella (MMR) vaccine is a combined vaccine of live attenuated virus. Since its approval, and although the adverse events are considered generally mild, the vaccine has been widely questioned for the controversies arising around its safety. Our objective was to describe suspected adverse events related to MMR vaccine reported to the Valencian Pharmacovigilance Centre…



Programme of Screening for Colorrectal Cancer in the Community Valenciana, Spain. Results of the First Round (2005-2008)

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background: Several studies evaluating colorectal cancer (CRC) screening with fecal occult blood testing (FOBT) have reported a significant reduction in mortality from this tumor. The study aims to describe the results of the first round of the CRC screening program in medium-risk population of Valencia and assessing their feasibility and acceptability. Methods: Colorectal cancer screening pilot study using biennial FOBT. All residents (106,000 Inhabitants) between 50 and 69 years old (a…



A survey of Heads of Surgery and Residents on accessibility and employment in liver transplant teams in Spain

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: The access of surgeons to liver transplant teams in Spain is heterogeneous. This study aims to portray the current human resources of Spanish transplant teams, distribution of transplant duties among team members, how transplant team members acquire their skills, their leaders' view of their future, as well the motivations of Spanish General Surgery residents to choose transplantation as their future career choice. Methods: Two different surveys were created, one for head…



Tratamiento farmacológico de la dependencia de sustancias desde una perspectiva neurocientífica (I): opiáceos y cocaína.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

In this review paper it is intended to analyze the most recent publications on pharmacological treatment of drug dependences from a neuroscientific perspective. It has been divided into two parts, the first one focuses on the treatment of illegal substance dependence, specifically opiates and cocaine; and the second part deals with the pharmacological treatments of three substances, two legal drugs such as alcohol and tobacco, and a group of medications with abuse potential, benzodiazepines. In…



Tratamiento farmacológico de la dependencia de sustancias desde una perspectiva neurocientífica (II): alcohol, benzodiacepinas y nicotina.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

The second part of this review deals with those neuroscientific aspects specific to the development and maintenance of dependence of three substances, two legal drugs (alcohol and tobacco) and a group of medications with abuse potential, benzodiazepines. Based on this context, the different pharmacological treatments of alcohol dependence, both related to detoxification and dehabituation, are discussed first. Treatment of the benzodiazepine withdrawal syndrome, together with the most…



Chronic idiopathic anal pain. Results of a diagnostic-therapeutic protocol in a colorectal referral unit.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Chronic idiopathic anal pain (CIAP) remains a diagnosis of exclusion. Its study and management still lack a standardized protocol. The aim of this study is to evaluate the results obtained with the diagnostic-therapeutic protocol established in our service.



Restless legs syndrome: detection, diagnosis, impact on health and utilization of health care resources

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction. Despite the high prevalence of Restless Legs Syndrome (RLS) reported, little information is available about this disorder in Spain. The present study was conducted to obtain information on this condition from patients identified by a simple screening questionnaire and subsequent diagnostic confirmation by the Primary Care Practitioner (PCP). Materials and methods. Three-stage, cross-sectional and retrospective (resource utilization), observational study in a sample of adult…



Risk of child poverty and social exclusion in two Spanish regions: social and family determinants.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Describe the risk of poverty and social exclusion in children aged 8-11 years from Gipuzkoa and Valencia (Spain), through AROPE (At Risk Of Poverty or Social Exclusion) indicators, and evaluate their associated factors in the INMA Project (Childhood and Environment).



Situación de la investigación en el cribado de cáncer de mama en España: implicaciones para la prevención

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

ObjetivoLa finalización del despliegue de los programas de detección precoz de cáncer de mama en todas las comunidades autónomas de España ha facilitado el inicio de una investigación conjunta, con información procedente de varios programas, orientada a mejorar su efectividad. MétodosSe ha construido una cohorte de más de 1 millón de mujeres cribadas para evaluar el riesgo y los determinantes de los resultados falsos positivos. Se ha evaluado el impacto del cambio de técnica de mamografía…



Women's satisfaction with waiting times for further investigation in breast cancer screening

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objectives: To determine the factors associated with satisfaction with waiting times for further investigation in breast cancer screening. Methods: We carried out a cross-sectional study by telephone survey of a representative sample of women (N = 316) participating in the breast cancer screening program of the autonomous region of Valencia (Spain) who required additional tests to confirm the diagnosis. Descriptive analysis was performed by contingency tables (p <0.05) and multivariate…



NOVICA: Characteristics and outcomes of patients who have a first episode of heart failure (de novo)

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background and objectives: To describe the clinical characteristics and prognosis (hospital mortality at 30 days and 12 months and emergency department readmission at 30 days for acute heart failure) of patients treated in hospital emergency departments for new-onset or de novo acute heart failure (NOAHF) and to compare the patients with those who consult for chronic decompensated heart failure (CDHF). Patients: NOVICA is a secondary analysis of the Epidemiology of Acute Heart Failure in…



Bladder pain syndrome: Prevalence and routine clinical practice in women attending functional urology and urodynamics units in Spain.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Bladder pain syndrome (BPS) is classified as a rare chronic debilitating disease and its diagnosis presents a challenge because its symptoms overlap with those associated with overactive bladder syndrome. The aim of the routine study was to estimate the prevalence of BPS and discover to study the profile of symptoms and clinical practice for patients attending functional urology and urodynamics units.



Executive functions and emotion regulation in obesity and eating disorders

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: eating disorders (ED) such as anorexia nervosa (AN) or bulimia nervosa (BN), as well as obesity (OB), are related to emotional and neuropsychological impairments on measures of cognitive fl exibility, central coherence or decision making. However, little is known about the association among emotional regulation, neuropsychological variables and affect. Objectives: to analyze whether neuropsychological and affect variables can predict emotional regulation in ED and in OB. Methods…



Simplification of the Barthel scale for screening for frailty and severe dependency in polypathological patients

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objectives: To analyze the sensitivity, specificity and positive predictive (PPV) and negative predictive (NPV) values of each measure of the Barthel index (BI) compared with the full questionnaire for polypathological patients (PPPs). Methods: Multicentre cross-sectional study. We considered 2 cut-off points for the BI (>= 90 points for screening frailty and <60 points for diagnosing severe dependence). For each measure and combination of 2 measures, we calculated the sensitivity,…



Change climate and health

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Climate change consists mainly of global warming, a result of the so-called greenhouse effect, which is caused by certain gases, including carbon dioxide (CO2), produced mainly through the combustion of fossil fuels, such as coal and oil. Global warming is a severe threat for future populations because it can cause a considerable rise in sea levels, a greater frequency and intensity of extreme meteorological phenomena and even the extinction of certain animal and plant species. In the field of…



A retrospective, multicenter analysis of incidents associated with Axios (TM) lumen-apposing stents

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: there is controversy with regard to the risks associated with lumen-apposing metal stents (LAMSs), with significant variations between available reports. Objectives: to describe the types and proportions of complications that arise during the permanence time and removal of Axios (TM) LAMS. Furthermore, the relationship between patency time, therapeutic target and the presence of complications was also described. Methods: a retrospective, multicenter case series study was…



Prospective, study comparing the accuracy of two different stool antigen tests (Premier Platinum HpSA and novel ImmunoCard STAT! rapid test) for the diagnosis of Helicobacter pylori infection.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

At present only monoclonal EIA (enzyme-immunoassay) stool antigen-tests have obtained optimal accuracy in the diagnosis of Helicobacter pylori. Our aim was to evaluate the accuracy of two stool antigen-tests, the validated Premier Platinum HpSA PLUS (EIA test) and the newly available ImmunoCard STAT! HpSA HD (rapid test) for the initial diagnosis and the confirmation of eradication of H. pylori infection.



Cost-effectiveness of hydrogel plugs in CT-guided lung biopsies

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objective: Using a hydrogel plug decreases the number of cases of pneumothorax and reduces the need for pleural drainage tubes in CT-guided lung biopsies. We aimed to analyze the costeffectiveness of using hydrogel plugs. Material and methods: We analyzed 171 lung biopsies divided into three groups: Group 1 (n= 22): fine-needle aspiration cytology (FNAC) without hydrogel plugs; Group 2 (n=89): FNAC with hydrogel plugs; and Group 3 (n=60): FNAC plus core-needle biopsy (CNB) with hydrogel plugs…



Clinical stages of patients with Alzheimer disease treated in specialist clinics in Spain. The EACE study

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: The diagnostic paradigm of Alzheimer disease (AD) is changing; there is a trend toward diagnosing the disease in its early stages, even before the complete syndrome of dementia is apparent. The clinical stage at which AD is usually diagnosed in our area is unknown. Therefore, the purpose of this study is to describe the clinical stages of AD patients at time of diagnosis. Methods: Multicentre, observational and cross-sectional study. Patients with probable AD according to…



Use of next generation sequencing technologies for the diagnosis and epidemiology of infectious diseases.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

For the first time, next generation sequencing technologies provide access to genomic information at a price and scale that allow their implementation in routine clinical practice and epidemiology. While there are still many obstacles to their implementation, there are also multiple examples of their major advantages compared with previous methods. Their main advantage is that a single determination allows epidemiological information on the causative microorganism to be obtained simultaneously…



Guía Española de la EPOC (GesEPOC). Tratamiento farmacológico de la EPOC estable.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Recognizing the clinical heterogeneity of COPD suggests a specific therapeutic approach directed by the so-called clinical phenotypes of the disease. The Spanish COPD Guidelines (GesEPOC) is an initiative of SEPAR, which, together with the scientific societies involved in COPD patient care, and the Spanish Patient Forum, has developed these new clinical practice guidelines. This present article describes the severity classification and the pharmacological treatment of stable COPD. GesEPOC…



Impacto de las exacerbaciones en la evolución de la EPOC.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

The clinical course of chronic obstructive pulmonary disease (COPD) is marked by frequent exacerbations. Not all patients suffer exacerbations and not all decompensations have the same consequences; however, in the last few years, these episodes of clinical instability - especially if recurrent - have come to be viewed as a major element in the natural history of the disease insofar as they generate heavy workload and high costs, síntonegatively affect patients' quality of life, contribute…



Ictus isquémico y apnea del sueño. Relación entre trastornos respiratorios durante el sueño y estenosis carotídea.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

To investigate the possible relation between the number of sleep breathing disorders (SBD) and significant extracranial carotid stenosis (ECS) in patients suffering ischemic stroke or transient ischemic attack (TIA).



Virology: syndromic diagnosis of meningitis and encephalitis.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Viral infections of the nervous system represent a major health problem. It is estimated that the incidence of viral meningitis in the general population ranges from 5-17 cases per 100,000 inhabitants per year in developed countries. This heading encompasses highly varied clinical pictures, ranging from meningitis to encephalitis. This article presents the agents involved in our environment and discusses their expressiveness. In immunocompetent patients, the course of these infections is…



Effectiveness of group therapy in women with localized breast cancer

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background/Objective: Breast cancer causes high levels of anxiety and depression, deteriorating quality of life of patients. Several studies have found that group therapy reduces depression and anxiety also improves the quality of life. The aim of this study is to analyze group therapy effectiveness in emotional state and quality of life in women with breast cancer after finalized medical treatments. Method: Participants in this study were 100 adult women diagnosed of breast cancer non-…



Multicentric study on total pancreatectomies

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: Total pancreatectomy (TP) is an uncommon operation, with indications that have not been clearly defined and non-standardized postoperative results. We present a national multicentric study on TP and a comparison with the existing literature Methods: A prospective observational study using data from the national registry of patients after pancreaticoduodenectomy and TP performed for any indication during the study period: January 1 to December 31, 2015 Results: 1016 patients were…



Use the mobile immunization teams to increase influenza vaccination coverage among heatlthcare workers. A community intervention trial

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background: The use of mobile immunization teams has been proposed as a strategy to increase influenza vaccination (IV) coverage among healthcare workers (HCW), but has not been evaluated in Primary Healthcare (PHC). The objective of this work was to determine if the use of mobile immunization teams increases IV coverage among HCW of a basic health area in the Valencian Community. Methods: Community intervention trial that included all HCWs from a basic health area in the Valencian Community.…



Postrenal failure due to entrapment of the ureter in inguinal hernia: a case-report

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Acute renal failure due to obstructive uropathy may be caused by inguinal hermias, either due to herniation of the urinary bladder, or in an exceptional manner, due to ureteral entrapment. We report a case of a patient with solitary kidney who suffers a progressive deterioration of renal function of unknown etiology. Physical examination revealed a reducible right inguinal hernia. Several examinations including ultrasonography and micturating cystourethrography that shows hydroureteronephrosis…



Validation and transcultural adaptation to spanish of the "Parental Supervision Attributes Profile Questionnaire"

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background: Child accidents are the most important preventable cause of morbidity and mortality in pediatric age. The degree of parental supervision is a factor that can influence, among others, in these accidents. The aim of this study was to validate and cross-culturally adapt to Spanish the questionnaire Parental Supervision Attributes Profile Questionnaire (PSAPQ) as a method of measuring the degree of parental supervision. Methods: Forward and back-translation methodology was applied…



Evaluation of the degree of adherence to the nutritional recommendations of the critical care patient

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background: the application of specialized nutritional support (SNE) is difficult at the organizational level due to the complexity of clinical practice guidelines and we do not know the degree of adherence to the published nutritional recommendations. The aim of this study was to assess the degree of adherence to the recommendations of high impact and "do not do" within our environment, in order to show areas for improvement. Methods: survey of nine questions agreed by experts and…



Factors associated with development of nephrotoxicity in patients treated with vancomycin versus daptomycin for severe Gram-positive infections: A practice-based study

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objectives. To evaluate nephrotoxicity development in patients treated with vancomycin (VAN) and daptomycin (DAP) for proven severe Gram-positive infections in daily practice. Patients and methods. A practice-based, observational, retrospective study (eight Spanish hospitals) was performed including patients >= 18 years with a baseline glomerular filtration rate (GFR)>30 mL/min and/or serum creatinine level<2 mg/dL treated with DAP or VAN for >48h. Nephrotoxicity was considered as…



Patients with acute heart failure discharged from the emergency department and classified as low risk by the MEESSI score (multiple risk estimate based on the Spanish emergency department scale): prevalence of adverse events and predictability

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objective. To determine the rate of adverse events in patients with acute heart failure (AHF) who were discharged from the emergency department (ED) after classification as low risk according to MEESSI score (multiple risk estimate based on the Spanish ED scale), to analyze the ability of the score to predict events, and to explore variables associated with adverse events. Methods. Patients in the EAHFE registry (Epidemiology of Acute Heart Failure in EDs) were stratified according to risk…



Chronic obstructive pulmonary disease (COPD) in Spain and the different aspects of its social impact: a multidisciplinary opinion document

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent diseases in the World, and one of the most important causes of mortality and morbidity. In adults 40 years and older, it affects more than 10% of the population and has enormous personal, family and social burden. Tobacco smoking is its main cause, but not the only one, and there is probably a genetic predisposition that increases the risk in some patients. The paradigm of this disease is changing in Spain, with an…



Portfolio of services and basic table of quality indicators for Headache Units: a consensus study

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Aim. To develop a proposal for a portfolio of services and a set of indicators for Headache Units. Development. Qualitative study that applied techniques of consensus with the participation of 15 professionals who are experts in the treatment of headaches (experience of 15 years) and in quality assurance. The description of the indicators included: statement, definition, standard, type of indicator, dimension, source, level of evidence, and clarification of terms. The proposal for a portfolio…



International Normalized Ratio and Mortality Risk in Acute Heart Failure and Nonvalvular Atrial Fibrillation Patients Receiving Vitamin K Antagonists

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction and objectives: Heart failure patients with nonvalvular atrial fibrillation (NVAF) on treatment with vitamin K antagonists (VKA) often have suboptimal international normalized ratio (INR) values. Our aim was to evaluate the association between INR values at admission due to acute heart failure and mortality risk during follow-up. Methods: In this observational study, we retrospectively assessed INR on admission in 1137 consecutive patients with acute heart failure and NVAF who…



Description of Influenza B in seasonal epidemics in Spain

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction. Seasonal influenza epidemics are a major public health concern. They are caused by the influenza A and B viruses; although the A virus is more prominent, influenza B virus infection causes a disease with similar characteristics. There are two phylogenetically distinct influenza B lineages (B/Victoria and B/Yamagata), only one of which is present in the trivalent vaccine formulated each season. Methods. Epidemiological data from the Spanish Influenza Surveillance System for 2007…



Use of hypotonic fluids in the prescription of maintenance intravenous fluid therapy

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: Isotonic fluids, in most cases, are the safest way to dispense fluids intravenously. The aim of this study was to determine the prescription of maintenance intravenous fluids and to study possible associated factors. Material and method: A descriptive, cross-sectional, multi-centre study was performed. A questionnaire was sent nationwide to several healthcare providers via an online survey, sent by email through different Medical Scientific Societies, and the Official Spanish…



The 8th edition of the AJCC-TNM classification: New contributions to the staging of esophagogastric junction cancer.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

The new 8th edition of the TNM classification system for esophageal and cardia or esophagogastric junction cancer provides important innovations in the TNM stages. Two classifications are presented, updated by stages, clinical (cTNM) and pathological (pTNM) methods, together with another pathological classification applicable to cases receiving neoadjuvant treatment (ypTNM). There is a notable increase in complexity compared to previous versions, but it is still early to determine whether the…



COVID-19 y enfermedad cardiovascular y renal: ¿Dónde estamos? ¿Hacia dónde vamos?

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

The SARS-CoV-2 pandemic is a global health emergency and we need to know more about it. Patients with cardiovascular risk and previous kidney risk have been identified as especially vulnerable for greater morbidity and mortality when they suffer from COVID-19. A considerable proportion of patients can develop a vascular lesion in the context of the disease that entails a greater lethality. Cardiovascular and renal complications represent a problem and, probably in the near future, may pose a…



Methods to smooth mortality indicators: application to analysis of inequalities in mortality in Spanish cities [the MEDEA Project]

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Although there is some experience in the study of mortality inequalities in Spanish cities, there are large urban centers that have not yet been investigated using the census tract as the unit of territorial analysis. The coordinated project,Socioeconomic and environmental inequalities in mortality in Spanish cities. The MEDEA project,, was designed to fill this gap, with the participation of 10 groups of researchers in Andalusia, Aragon, Catalonia, Galicia, Madrid, Valencia, and the Basque…



Prescription patterns of antihyperglycemic drugs in elderly patients in Spain: A national cross-sectional study.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Elderly patients with type 2 diabetes represent a growing and heterogeneous group of subjects where treatment targets and antihyperglycemic drugs prescriptions should be tailored according to coexisting illnesses, functional and social domains.



Sacubitril/valsartan-treated patients with exacerbated acute heart failure: approaches to care in the emergency department and on the ward

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objectives. To describe the pattern of care usually given to patients with acute heart failure (AHF) who are taking sacubitril/valsartan (SV) and to explore the effects of care characteristics on clinical outcomes. Methods. Exploratory study of AHF cases in patients taking SV who were included in the register for the Epidemiology of Acute Heart Failure in Emergency Departments during the sixth period of data collection (EAHFE-6). We extracted baseline and episode variables and information…



La alimentación como fuente de conflicto entre paciente y familia en cuidados paliativos.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

conflicts are part of human relationships. Few studies have looked at the conflicts that food can produce at the end of life, the factors that affect its appearance, and the way to manage them. This knowledge would help healthcare teams to improve the care of these patients and their families.



Validación y adaptación transcultural al español del Parental Supervision Attributes Profile questionnaire: método de medición de la supervisión parental.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Child accidents are the most important preventable cause of morbidity and mortality in pediatric age. The degree of parental supervision is a factor that can influence, among others, in these accidents. The aim of this study was to validate and cross-culturally adapt to Spanish the questionnaire Parental Supervision Attributes Profile Questionnaire (PSAPQ) as a method of measuring the degree of parental supervision.



Characterization of folate supplementation in pregnancy, based on a combination of health information systems

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objectives: To explore the utility of combining health information systems from the Valencia Health Agency to characterize folate supplementation in pregnant women in the autonomous region of Valencia (Spain). Methods: The cohort comprised women who gave birth during 2009 in hospitals within the Valencian Health Agency. These women were retrospectively followed-up using ABUCASIS electronic medical records and the GAIA electronic prescription system to identify folate consumption in the 3…



Pharmaceutical prescription in primary care. SESPAS report 2012

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

In 2010, the Spanish National Health Service (NHS) paid for 958 million prescriptions. Given the massive population exposure to medication, the risks associated with drug consumption are highly significant from the perspective of public health. Areas requiring improvement in primary care prescription include overtreatment of patients in low risk situations, undertreatment of those in whom medication is indicated, poor patient information, polymedication, self-medication and the appreciable…



Variations in antihypertensiye drug utilization among primary care areas in the autonomous region of Valencia (Spain)

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Objectives: To estimate consumption of five subgroups of antihypertensive drugs by primary care areas and to analyze its variation. Methods: We performed an ecological, descriptive study of antihypertensive consumption in 239 primary care areas in the autonomous region of Valencia in 2005 followed by analysis of the variability observed. The 239 primary care areas were studied by descriptive analysis of dispensation [defined daily dose (DDD) per 1,000 inhabitants/day in pensioners (DDD/1000p/…



Population Analysis by Area of Health of Changes in Consumption, Price and Expenditure of Cardiovascular Drugs in Eight Autonomous Communities, Spain, 2005

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background: Variability in cardiovascular drugs is of great interest because of its high population use, its high expenditure and the availability of strong evidence supporting its use. The aim of this study is to describe variation in dispensation, price and pharmaceutical expenditure for 11 subgroups of cardiovascular drugs by healthcare areas. Methods: This was a population study describing dispensation for 11 subgroups of cardiovascular drugs among healthcare areas in 2005. Population: 93…



Associations and community health workers: analysis and time trends over ten years of training-action.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

OBJECTIVE: To analyse the profile of the persons and associations that participated in the course, quantify peer education activities and analyse their evolution. METHOD: A quantitative study using an analysis of the course records from 2009 to 2018 was designed for this purpose inside mihsalud program designed to promote health amongst persons in vulnerable situations in the city of Valencia (Spain). It offers a yearly training-action course of community health workers (CHW) that is…



Infección tardía por estreptococo grupo B en gemelos nacidos mediante cesárea.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Group B Streptococcus (GBS) is a commensal pathogen of the gut microflora with a well-established role in the aetiology of early and late onset GBS infections in the newborn. The incidence of early onset infections by vertical transmission has been drastically reduced in recent decades with the use of intravenous intrapartum prophylaxis. Progress in risk factor detection and prophylaxis of late-onset infection has however remained static. The ongoing modifications and improvements of the…



Posicionamiento para el manejo de la hipertensión arterial en atención primaria a partir del análisis crítico de las guías americana (2017) y europea (2018). Sociedad Española de Médicos de Atención Primaria (SEMERGEN).

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

The Scientific Societies of Primary Care, being the area in which there is a considerable prevalence of Arterial Hypertension (AHT), need to periodically evaluate the international guidelines for its management. This is particularly relevant when disparate guidelines make it difficult to make decisions in daily clinical practice. The present document has as its aim to analyse the changes and new developments proposed in the guidelines of the American College of Cardiology and the American Heart…



Executive Summary of the Consensus Statement of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Tropical Medicine and International Health (SEMTSI), the Spanish Association of Surgeons (AEC), the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), the Spanish Society of Thoracic Surgery (SECT), the Spanish Society of Vascular and Interventional Radiology (SERVEI), and the Spanish Society of Paediatric Infectious Diseases (SEIP), on the Management of Cystic Echinococcosis.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

The Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Tropical Medicine and International Health (SEMTSI), the Spanish Association of Surgeons (AEC), the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), the Spanish Society of Thoracic Surgery (SECT), the Spanish Society of Vascular and Interventional Radiology (SERVEI), and the Spanish Society of Paediatric Infectious Diseases (SEIP) considered it pertinent to issue a consensus…



Congenital heart defects in the Valencian Community 2007-2014: The Population-Based Registry Of Congenital Anomalies

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: Congenital heart defects (CHDs) are the most prevalent and severe type of major congenital anomalies (CAs). The objective of this study was to determine the frequency and distribution of CHDs in the Valencian Region from 2007 to 2014, describing common characteristics of the patients and their mothers. Material and Methods: We retrieved data on CHDs in live births, stillbirths and cases of termination of pregnancy for fetal anomaly between 2007 and 2014 (codes Q20-Q26 in the 10th…



Immunisation schedule of the Spanish Association of Paediatrics: 2020 recommendations

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

The CAV-AEP annually publishes the immunisation schedule considered optimal for all children resident in Spain, taking into account the available evidence. The 2 + 1 schedule is recommended (2, 4, and 11 months) with hexavalent vaccines (DTPa-VPI-Hib-HB) and with 13-valent pneumococcal conjugate. A 6-year booster is recommended, preferably with DTPa (if available), with a dose of polio for those who received 2 + 1 schemes, as well as vaccination with Tdpa in adolescents and in each pregnancy…



Food policies to prevent obesity and the main non-transmissible diseases in Spain: where there's a will there's a way

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: In Spain, one third of all children and two-thirds of adults suffer from excess weight, a condition that generates a direct excess medical cost of 2000 million Euros. Obesogenic food environments cause obesity by promoting the consumption of sugar-sweetened beverages and ultra-processed foods. Accordingly, we propose five priority policies capable of reversing the epidemic of obesity and related non-communicable diseases through the creation of healthy food environments. The…



Reasons for noncompliance with the national guidelines for initial antiretroviral therapy of HIV-infected patients in Spain, 2010-2015

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Introduction: Our aims were to investigate the adherence to national guidelines of initial antiretroviral therapy (ART) in the Spanish multicenter CoRIS cohort during the years 2010-2015, to identify the reasons for the prescription of nonrecommended treatments, and to explore the role of institutional constraints to guideline compliance. Methods: ART regimens were classified as recommended, alternative or nonrecommended according to the guidelines. Physicians were asked the reasons for…



Wilson disease: The look of medical staff, patients and family members

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Background: Wilson disease (WD) is a rare congenital disease that causes hepatic, neurological or lenticular degeneration due to the accumulation of copper. Sometimes it is incapacitating with implications in the quality of life of those of affected and their families. The objective of this work was to identify the needs of medical staff and the social and emotional needs of patients with WD and their families. Methods: A qualitative research was developed in the Valencian Region during 2015-…



First hospital contact via the Emergency Department is an independent predictor of overall survival and disease-free survival in patients with colorectal cancer

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Aims: the aim of this study was to examine the possible association between the type of hospital admission and subsequent survival of the patient, as well as the pathological features recorded in a large population of patients with colorectal cancer. Methods: the study included 1,079 patients diagnosed with colon or rectal cancer in the Hospital Costa del Sol (Marbella, Spain). The relationship between patient survival rate and type of first admission to the hospital (elective or emergency…



What is the diet of the immigrant population resident in Spain? Results based on a systematic review

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Diet is a principal determinant of health and is interrelated with socioeconomic factors and the acculturation of immigrants. The aim of this study was to examine the existing evidence on food, nutrition, and diet amongst immigrant populations in Spain, its relationships with their countries of origin, and to evaluate the methodological quality of these studies. A systematic review was carried out that included seventeen cross-sectional studies, 71% of them were of average quality and only one…



Novel findings in the management of acute pancreatitis.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

Acute pancreatitis (AP) is a potentially serious disease whose incidence is on the increase. Pancreas divisum does not meet the required criteria to be considered an aetiological factor. Sphincter of Oddi dysfunction may be another cause of idiopathic AP. Less invasive methods cannot replace Sphincter of Oddi manometry in diagnosis. Almost half of patients with systemic inflammatory response syndrome develop organ failure, but the mechanisms involved are not completely understood. Obesity is a…



Calidad, Innovación y Desarrollo tecnológico en nutrición enteral en el siglo XXI.

Repositorio: r-FISABIO: Repositorio Institucional de Producción Científica

This work synthesis the quality evolution as well as innovation and technological advances that have been proven in healthcare area and specifically in enteral nutrition field. Clarifying the most relevant landmarks and the best representative characteristics of these advances.