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Association of Moderate-to-Vigorous Physical Activity, Sedentary Time, Fat Percentage, and Physical Fitness with Gait Parameters in Women with Fibromyalgia: The Al-Ándalus Project

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Sergio Llorente-Romero, Manuel Herrador-Colmenero, Pedro Acosta-Manzano, Milkana Borges-Cosic, Blanca Gavilán-Carrera, Pedro Ángel Latorre Román, Manuel Delgado-Fernández, Segura-Jiménez, Víctor

Gait impairments have been found in women with fibromyalgia, reducing the physical activity possibilities in this population and leading to a negative correlation with fibromyalgia impact. The aim of this study was to analyze the individual and independent associations of moderate-to-vigorous physical activity (MVPA), sedentary time, fat percentage, and physical fitness with gait parameters in women with fibromyalgia. A total of 84 women with fibromyalgia were included. MVPA and sedentary time…



Vol. 28, nº 33. La mortalidad y sus causas en Andalucía en 2021

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Servicio de Vigilancia y Salud Laboral

Enfermedades de Declaración Obligatoria por provincias. Semana 32/2023 y acumulado desde la semana 01/2023. Datos provisionales. Incluye además el artículo titulado “La mortalidad y sus causas en Andalucía en 2021”, de “Soledad Márquez Calderón”.



Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Decara, Juan M, Pavón, Francisco Javier, Suárez, Juan, Romero-Cuevas, Miguel, Baixeras, Elena, Vázquez, Mariam, Rivera, Patricia, Gavito, Ana L, Almeida, Bruno, Joglar, Jesús, de la Torre, Rafael, Rodríguez de Fonseca, Fernando, Serrano, Antonia

Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized the in vivo effects of a novel conjugation of oleic acid with an amphetamine derivative (OLHHA) in an animal model of genetic obesity. Lean and obese Zucker rats received a daily intraperitoneal administration of OLHHA (5 mg kg(-1)) for 15 days. Plasma and liver samples…



Blood pressure-lowering effects of nifedipine/candesartan combinations in high-risk individuals: subgroup analysis of the DISTINCT randomised trial

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Mancia, G, Cha, G, Gil-Extremera, B, Harvey, P, Lewin, A J, Villa, G, Kjeldsen, S E

The DISTINCT study (reDefining Intervention with Studies Testing Innovative Nifedipine GITS-Candesartan Therapy) investigated the efficacy and safety of nifedipine GITS/candesartan cilexetil combinations vs respective monotherapies and placebo in patients with hypertension. This descriptive sub-analysis examined blood pressure (BP)-lowering effects in high-risk participants, including those with renal impairment (estimated glomerular filtration rate<90 ml min(-1), n=422), type 2 diabetes…



Programa Integral de Silicosis de Andalucía en el manipulado de aglomerados de cuarzo : PISA

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Álvarez Zarallo, Juan Francisco, Cabrera Eisman, Juan Pedro, Córdoba Doña, Juan Antonio, García Ruiz, Fernando, Leal Reina, Francisco Javier, Rabadán Asensio, Andrés

Las Consejerías de Salud y de Empleo, Empresa y Comercio han identificado como problema relevante el aumento en la incidencia de silicosis (enfermedad profesional caracterizada por fibrosis pulmonar y predisposición al cáncer de pulmón) concretamente en el sector específico de “corte, tallado y acabado de piedra” (CNAE‐2009: 2370), por lo que han venido desarrollando acciones conjuntas, con el objetivo de preveer y controlar este riesgo laboral, dirigidas a todos los agentes implicados, como…



La Acción Conjunta CHRODIS (“Acción Conjunta Europea para la Prevención de las enfermedades crónicas y la promoción del envejecimiento saludable a través del ciclo vital”)

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Servicio de Promoción y Acción Local en Salud. Subdirección Promoción, Participación y Planes de Salud. Secretaría General de Salud Pública y Consumo. Consejería de Salud Junta de Andalucía

CHRODIS es la primera Acción Conjunta sobre Enfermedades Crónicas puesta en marcha a nivel comunitario, en el marco del Programa de Salud de la Comisión Europea. Otorga un especial énfasis a la promoción de la salud para abordar la prevención primaria de esta problemática y uno de sus objetivos principales es estimular el intercambio de buenas prácticas entre las regiones y países comunitarios.



Informe epidemiológico de las enfermedades transmisibles y no transmisibles. Andalucía. Año 2018

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Rodríguez Romero, Elisa, Candau Bejarano, Ana, Durán Plá, Enric, Pérez Morilla, Esteban, Arroyo Yanes, Francisco, Bernal Vela, Francisco, Andérica Frías, Gloria, Guillén Enriquez, Javier, Carmona Lagares, Juan Carlos, Lorusso, Nicola, Fernández Alonso, Teresa, Gallardo García, Virtudes

Este informe tiene como objetivo favorecer la difusión oportuna de información epidemiológica, contribuyendo a dar respuesta adecuada de salud pública. Presenta los resultados de vigilancia de las enfermedades transmisibles y no transmisibles realizados en el año 2018. La Red de Vigilancia es la Red Alerta, detecta e interviene de manera urgente y eficaz, ante situaciones de riesgo para la salud pública, potenciales, reales o que generen alarma social. Forma parte de esta Red, profesionales de…



New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Muñoz-Galván, Sandra, Felipe-Abrio, Blanca, García-Carrasco, Miguel, Domínguez-Piñol, Julia, Suarez-Martinez, Elisa, Verdugo-Sivianes, Eva M., Espinosa-Sánchez, Asunción, Navas, Lola E., Otero-Albiol, Daniel, Marin, Juan J., Jiménez-García, Manuel P., García-Heredia, Jose M., Quiroga, Adoración G., Estevez-Garcia, Purificacion, Carnero, Amancio

Background: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequent lines of treatment and to a poor survival. Therefore, a comprehensive understanding of the mechanisms that drive platinum resistance is urgently needed. Methods: We used bioinformatics analysis of public databases and RT-qPCR to quantitate the relative…



Consensus on Criteria for Good Practices in Video Consultation: A Delphi Study

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Jiménez-Rodríguez, Diana, Ruiz-Salvador, Diego, Rodríguez Salvador, María del Mar, Pérez-Heredia, Mercedes, Muñoz Ronda, Francisco José, Arrogante, Oscar

The use of telemedicine has greatly increased, largely derived from the COVID-19 pandemic, which has created the need for a guide aimed towards the adequate management of a modality of health care: the video consultation. A Delphi study composed of three rounds was conducted with 16 experts in holding video consultations and managing non-technical skills from different specialties and nationalities to conceive a consensus on the criteria needed for properly managing video consultations by…



Development and External Validity of a Short-Form Version of the INICIARE Scale to Classify Nursing Care Dependency Level in Acute Hospitals

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Porcel-Gálvez, Ana María, Barrientos-Trigo, Sergio, Fernández-García, Elena, Allande-Cussó, Regina, Quiñoz-Gallardo, María Dolores, Morales-Asencio, José Miguel

Background: The increasing dependence care in patients hospitalized in acute hospitals around the world entails classification systems heeding the wide range of care dependency levels generated by the many different types of dependent patients. This article is a report of a study assessing the validity and reliability of a short-from version of the instrument (Inventario del NIvel de Cuidados mediante Indicadores de Resultados de Enfermería (INICIARE)) used to classify inpatients according to…



Ultrasound-assisted intralesional corticosteroid infiltrations for patients with hidradenitis suppurativa

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Salvador-Rodríguez, Luis, Arias-Santiago, Salvador, Molina-Leyva, Alejandro

Corticosteroid infiltrations of lesions in hidradenitis suppurativa (HS) appear to be beneficial to acute flares. The aim of this study is to evaluate the effectiveness and safety of ultrasound-assisted intralesional corticosteroid infiltrations to HS lesions. Prospective cohort study between February 2017 and February 2019 on patients with mild to severe HS and one or more inflammatory lesions. The study intervention was ultrasound-assisted intralesional infiltration of triamcinolone acetonide…



Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Calderón-Parra, Jorge, Kestler, Martha, Ramos-Martínez, Antonio, Bouza, Emilio, Valerio, Maricela, de Alarcón, Arístides, Luque, Rafael, Goenaga, Miguel Ángel, Echeverría, Tomás, Fariñas, M. Carmen, Pericàs, Juan M., Ojeda-Burgos, Guillermo, Fernández-Cruz, Ana, Plata, Antonio, Vinuesa, David, Muñoz, Patricia

We aimed to identify clinical factors associated with recurrent infective endocarditis (IE) episodes. The clinical characteristics of 2816 consecutive patients with definite IE (January 2008-2018) were compared according to the development of a second episode of IE. A total of 2152 out of 2282 (94.3%) patients, who were discharged alive and followed-up for at least the first year, presented a single episode of IE, whereas 130 patients (5.7%) presented a recurrence; 70 cases (53.8%) were due to…



In-Treatment Changes in Quality of Life-Related Variables in Therapeutic Communities for Cocaine Abusers: Are These Changes Associated with Clinical Outcomes?

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
González-Saiz, Francisco, Vergara-Moragues, Esperanza

Background: Few studies have explored changes in quality of life during the first three months of admission to a therapeutic community for addictions. The objective of this study was to determine the relationship between these changes and treatment outcomes at discharge. Methods: We undertook a prospective longitudinal study of 142 cocaine-dependent patients treated at a therapeutics community. All of these patients reached the 3-month evaluation and were subsequently followed until discharge.…



Guías de Práctica Clínica sobre Hemoterapia: informe de respuesta breve: listado de referencias comentadas

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Acosta García, Héctor, Castro Campos, José Luis

El documento recoge la metodología y las guías de práctica clínica (GPC) identificadas en las que se abordaron criterios de calidad, acreditación, estructura y organización de las unidades en las que se realizan transfusiones y donación de sangre o de componentes sanguíneos.



Impact of an Antimicrobial Stewardship Program on the Incidence of Carbapenem Resistant Gram-Negative Bacilli: An Interrupted Time-Series Analysis

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
López-Viñau, Teresa, Peñalva, Germán, García-Martínez, Lucrecia, Castón, Juan José, Muñoz-Rosa, Montserrat, Cano, Ángela, Recio, Manuel, Cisneros, José Miguel, Pérez-Nadales, Elena, Rumbao Aguirre, José, García-Martínez, Elena, Salcedo, Inmaculada, Del Prado, José Ramón, de la Fuente, Carmen, Martínez-Martínez, Luis, Gracia-Ahufinger, Irene, Torre-Cisneros, Julián

Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a critical public health threat, and carbapenem use contributes to their spread. Antimicrobial stewardship programs (ASPs) have proven successful in reducing antimicrobial use. However, evidence on the impact of carbapenem resistance remains unclear. We evaluated the impact of a multifaceted ASP on carbapenem use and incidence of CR-GNB in a high-endemic hospital. An interrupted time-series analysis was conducted one year before and two…



The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Peter, Jessica, Mayer, Isabella, Kammer, Thomas, Minkova, Lora, Lahr, Jacob, Klöppel, Stefan, Grothe, Michel J., Orth, Michael

We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central cholinergic signal transmission. Healthy volunteers (n = 36) and patients with mild cognitive impairment (MCI, n = 20) underwent median nerve SAI and 3T structural MRI to determine the volume of the basal forebrain and the thalamus. Patients with MCI had smaller…



Municipal distribution of bladder cancer mortality in Spain: Possible role of mining and industry

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Lopez-Abente, Gonzalo, Aragones, Nuria, Ramis, Rebeca, Hernandez-Barrera, Valentin, Perez-Gomez, Beatriz, Escolar-Pujolar, Antonio, Pollan, Marina

BACKGROUND Spain shows the highest bladder cancer incidence rates in men among European countries. The most important risk factors are tobacco smoking and occupational exposure to a range of different chemical substances, such as aromatic amines. METHODS This paper describes the municipal distribution of bladder cancer mortality and attempts to "adjust" this spatial pattern for the prevalence of smokers, using the autoregressive spatial model proposed by Besag, York and Molliè, with…



Tratamiento nutricional del fallo intestinal y potenciales mecanismos de estimulación., Nutritional management of intestinal failure and potential stimulation mechanisms

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Pérez de la Cruz, A J, Moreno-Torres Herrera, R, Pérez Roca, C

El Fallo Intestinal en sus formas graves representa una de las patologías de manejo más complejo, tanto en niños como adultos. En adultos las causas más frecuentes son la Pseudoobstrucción Intestinal Crónica y el Síndrome del Intestino Corto severo que sigue a las grandes resecciones intestinales, sobre todo las debidas a isquemia mesentérica masiva, en el marco de cardiopatías que cursan con fibrilación auricular. El tratamiento fundamental tras la estabilización del paciente, está…



Improved 6-year overall survival in AT/RT - results of the registry study Rhabdoid 2007.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Bartelheim, Kerstin, Nemes, Karolina, Seeringer, Angela, Kerl, Kornelius, Buechner, Jochen, Boos, Joachim, Graf, Norbert, Dürken, Matthias, Gerss, Joachim, Hasselblatt, Martin, Kortmann, Rolf-Dieter, Teichert von Luettichau, Irene, Nagel, Inga, Nygaard, Randi, Oyen, Florian, Quiroga, Eduardo, Schlegel, Paul-Gerhardt, Schmid, Irene, Schneppenheim, Reinhard, Siebert, Reiner, Solano-Paez, Palma, Timmermann, Beate, Warmuth-Metz, Monika, Frühwald, Michael Christoph

Atypical teratoid rhabdoid tumors (AT/RT) are characterized by mutations and subsequent inactivation of SMARCB1 (INI1, hSNF5), a predilection for very young children and an unfavorable outcome. The European Registry for rhabdoid tumors (EU-RHAB) was established to generate a common European database and to establish a standardized treatment regimen as the basis for phase I/II trials. Thus, genetic analyses, neuropathologic and radiologic diagnoses, and a consensus treatment regimen were…



Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Calleja-Conde, Javier, Echeverry-Alzate, Victor, Giné, Elena, Bühler, Kora-Mareen, Nadal, Roser, Maldonado, Rafael, Rodríguez de Fonseca, Fernando, Gual, Antoni, López-Moreno, Jose Antonio

The opioid antagonist nalmefene (selincro®) was approved for alcohol-related disorders by the European Medicines Agency in 2013. However, there have been no studies regarding the effectiveness of nalmefene when alcohol is used in combination with cocaine. Using operant alcohol self-administration in Wistar rats and qRT-PCR, we evaluated (i) the dose-response curve for s.c. and p.o. nalmefene; (ii) the effects of nalmefene with increasing concentrations of alcohol; (iii) the efficacy of…



Burden of First Osteoporotic Hip Fracture in Spain: A Prospective, 12-Month, Observational Study.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Caeiro, Jose Ramón, Bartra, Agustí, Mesa-Ramos, Manuel, Etxebarría, Íñigo, Montejo, Jorge, Carpintero, Pedro, Sorio, Francesc, Gatell, Sonia, Farré, Andrea, Canals, Laura, PROA investigators

The purpose of this study was to estimate the burden of osteoporotic fractures beyond the hospitalization period covering up to the first year after the fracture. This was a prospective, 12-month, observational study including patients aged ≥65 years hospitalized due to a first low-trauma hip fracture, in six Spanish regions. Health resource utilization (HRU), quality of life (QoL) and autonomy were collected and total costs calculated. Four hundred and eighty seven patients (mean ± SD age 83…



Manual de procesos en protección. 2ª ed.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Gómez López, Catalina, Blancas Cabello, Carmen, Conejo Díaz, José Antonio, González Gómez, María, Ortiz Domínguez, Alonso, Peinado Álvarez, Jesús, Pérez-Rendón González, José, Sánchez-Laulhé Ollero, Rosario, Tarancón Estrada, María, Vallino Llabrés, María Fernanda

Desde la publicación de la primera edición en 2008, este manual ha servido de soporte para la implantación de la metodología de procesos en Protección de la salud. Con esta segunda edición se pretende poner en manos de todos los técnicos de Protección de la Salud y personas interesadas en el tema, una herramienta imprescindible, a la hora de abordar el diseño y la implantación de la metodología por procesos, tanto en el campo de la Seguridad Alimentaria, como de la Salud Ambiental.



[Recommendations for the use of rapid diagnosis techniques in respiratory infections in primary care]., Recomendaciones de utilización de técnicas de diagnóstico rápido en infecciones respiratorias en atención primaria.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Llor, Carles, Alkorta Gurrutxaga, Miriam, de la Flor I Bru, Josep, Bernárdez Carracedo, Sílvia, Cañada Merino, José Luis, Bárcena Caamaño, Mario, Serrano Martino, Carmen, Cots Yago, Josep Maria

Respiratory tract infections rank first as causes of adult and paediatric infectious morbidity in primary care in Spain. These infections are usually self-limiting and are mainly caused by viruses. However, a high percentage of unnecessary antibiotic prescription is reported. Point-of-care tests are biomedical tests, which can be used near the patient, without interference of a laboratory. The use of these tests, many of which have been recently developed, is rapidly increasing in general…



Predicting the risk of cancer after unprovoked venous thromboembolism: external validation of the RIETE score.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Bertoletti, L, Robin, P, Jara-Palomares, L, Tromeur, C, Pastre, J, Prevot-Bitot, N, Mouneh, T, Le Gal, G, Salaun, P-Y, MVTEP investigators

Essentials Patients at high-risk of occult cancer may benefit from extensive screening. We validated the RIETE cancer score in the MVTEP study. One in three patients were classified as high-risk, 10% of whom had cancer diagnosed. The RIETE score identifies a subgroup at high risk for cancer. Background Most recent trials evaluating extensive screening strategies for occult cancer in patients with unprovoked venous thromboembolism have failed, because, among other reasons, of an overall low rate…



ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [I]: anti-tumor necrosis factor-α agents).

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Baddley, J W, Cantini, F, Goletti, D, Gómez-Reino, J J, Mylonakis, E, San-Juan, R, Fernández-Ruiz, M, Torre-Cisneros, J

The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. To review, from an Infectious Diseases perspective, the safety profile of agents targeting tumour necrosis factor-α (TNF-α) and to suggest preventive recommendations. Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family. Preclinical and clinical evidence indicate that anti-TNF-α therapy…



Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Dierssen-Sotos, Trinidad, Palazuelos-Calderón, Camilo, Jiménez-Moleón, José-Juan, Aragonés, Nuria, Altzibar, Jone M, Castaño-Vinyals, Gemma, Martín-Sanchez, Vicente, Gómez-Acebo, Inés, Guevara, Marcela, Tardón, Adonina, Pérez-Gómez, Beatriz, Amiano, Pilar, Moreno, Victor, Molina, Antonio J, Alonso-Molero, Jéssica, Moreno-Iribas, Conchi, Kogevinas, Manolis, Pollán, Marina, Llorca, Javier

Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic.…



Spatial and temporal variability of personal environmental exposure to radio frequency electromagnetic fields in children in Europe.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Birks, Laura Ellen, Struchen, Benjamin, Eeftens, Marloes, van Wel, Luuk, Huss, Anke, Gajšek, Peter, Kheifets, Leeka, Gallastegi, Mara, Dalmau-Bueno, Albert, Estarlich, Marisa, Fernandez, Mariana F, Meder, Inger Kristine, Ferrero, Amparo, Jiménez-Zabala, Ana, Torrent, Maties, Vrijkotte, Tanja G M, Cardis, Elisabeth, Olsen, Jørn, Valič, Blaž, Vermeulen, Roel, Vrijheid, Martine, Röösli, Martin, Guxens, Mònica

Exposure to radiofrequency electromagnetic fields (RF-EMF) has rapidly increased and little is known about exposure levels in children. This study describes personal RF-EMF environmental exposure levels from handheld devices and fixed site transmitters in European children, the determinants of this, and the day-to-day and year-to-year repeatability of these exposure levels. Personal environmental RF-EMF exposure (μW/m2, power flux density) was measured in 529 children (ages 8-18 years) in…



The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Rodríguez-Nogales, Alba, Algieri, Francesca, Garrido-Mesa, José, Vezza, Teresa, Utrilla, Maria P, Chueca, Natalia, Fernández-Caballero, Jose A, García, Federico, Rodríguez-Cabezas, Maria E, Gálvez, Julio

The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with…



Evidence of the Red-Queen Hypothesis from Accelerated Rates of Evolution of Genes Involved in Biotic Interactions in Pneumocystis.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Delaye, Luis, Ruiz-Ruiz, Susana, Calderon, Enrique, Tarazona, Sonia, Conesa, Ana, Moya, Andrés

Pneumocystis species are ascomycete fungi adapted to live inside the lungs of mammals. These ascomycetes show extensive stenoxenism, meaning that each species of Pneumocystis infects a single species of host. Here, we study the effect exerted by natural selection on gene evolution in the genomes of three Pneumocystis species. We show that genes involved in host interaction evolve under positive selection. In the first place, we found strong evidence of episodic diversifying selection in Major…



4 a 6 años. Información básica para la crianza

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Consejería de Salud y Bienestar Social

Información dirigida a padres y madres relativa a la alimentación, cuidados y prevención de accidentes entre el cuarto y el sexto año del niño.



Projecting Pharmaceutical Expenditure in EU5 to 2021: Adjusting for the Impact of Discounts and Rebates.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Espin, Jaime, Schlander, Michael, Godman, Brian, Anderson, Pippa, Mestre-Ferrandiz, Jorge, Borget, Isabelle, Hutchings, Adam, Flostrand, Steven, Parnaby, Adam, Jommi, Claudio

Within (European) healthcare systems, the predominant goal for pharmaceutical expenditure is cost containment. This is due to a general belief among healthcare policy makers that pharmaceutical expenditure-driven by high prices-will be unsustainable unless further reforms are enacted. The aim of this paper is to provide more realistic expectations of pharmaceutical expenditure for all key stakeholder groups by estimating pharmaceutical expenditure at 'net' prices. We also aim to…



Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Fernandez-Fernandez, Seila, Bobo-Jimenez, Veronica, Requejo-Aguilar, Raquel, Gonzalez-Fernandez, Silvia, Resch, Monica, Carabias-Carrasco, Monica, Ros, Joaquim, Almeida, Angeles, Bolaños, Juan P

Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not been unambiguously elucidated. Previous attempts to address this issue were approached by fully eliminating glutathione, a strategy causing abrupt lethality or premature neuronal death that led to multiple interpretations. To overcome this drawback, here we aimed to moderately…



Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Park, Jin Young, Bueno-de-Mesquita, H Bas, Ferrari, Pietro, Weiderpass, Elisabete, de Batlle, Jordi, Tjønneland, Anne, Kyro, Cecilie, Rebours, Vinciane, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kritikou, Maria, Masala, Giovanna, Pala, Valeria, Tumino, Rosario, Panico, Salvatore, Peeters, Petra H, Skeie, Guri, Merino, Susana, Duell, Eric J, Rodríguez-Barranco, Miguel, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Ardanaz, Eva, Gylling, Björn, Schneede, Jörn, Ericson, Ulrika, Sternby, Hanna, Khaw, Kay-Tee, Bradbury, Kathryn E, Huybrechts, Inge, Aune, Dagfinn, Vineis, Paolo, Slimani, Nadia

Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident…



Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Khalid, Sara, Calderon-Larrañaga, Sara, Hawley, Samuel, Ali, M Sanni, Judge, Andrew, Arden, Nigel, van Staa, Tjeerd, Cooper, Cyrus, Javaid, Muhammad Kassim, Prieto-Alhambra, Daniel

This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. We investigated two primary care records databases covering UK National Health Service (Clinical Practice Research Datalink, CPRD) and Catalan healthcare (Information System for Research in Primary Care, SIDIAP) patients during 1995-2014 and 2006-2014, respectivey. Treatment-naive incident users of anti-osteoporosis…



Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE registry.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Bertoletti, Laurent, Quenet, Sara, Laporte, Silvy, Sahuquillo, Joan Carles, Conget, Francisco, Pedrajas, José María, Martin, Mar, Casado, Ignacio, Riera-Mestre, Antonio, Monreal, Manuel

BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentation on the 3-month outcomes in COPD patients. METHODS COPD patients included in the on-going world-wide RIETE Registry were studied. The rate of pulmonary embolism (PE), major bleeding and death…



One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Vrieling, Alina, Bueno-De-Mesquita, H Bas, Ros, Martine M, Kampman, Ellen, Aben, Katja K, Büchner, Frederike L, Jansen, Eugène H, Roswall, Nina, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Chang-Claude, Jenny, Kaaks, Rudolf, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Panico, Salvatore, Peeters, Petra H, Weiderpass, Elisabete, Skeie, Guri, Jakszyn, Paula, Chirlaque, María-Dolores, Ardanaz, Eva, Sánchez, María-José, Ehrnström, Roy, Malm, Johan, Ljungberg, Börje, Khaw, Kay-Tee, Wareham, Nick J, Brennan, Paul, Johansson, Mattias, Riboli, Elio, Kiemeney, Lambertus A

Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824…



The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Ariza, Laura, Rojas, Anabel, Muñoz-Chápuli, Ramón, Carmona, Rita

The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart. Recent findings suggest that WT1 could also be playing physiological roles in adults. Systemic deletion of WT1 in mice provokes a severe deterioration of the exocrine pancreas, with mesothelial disruption, E-cadherin downregulation, disorganization of acinar architecture and accumulation of ascitic transudate.…



Positive/retained SDHB immunostaining in renal cell carcinomas associated to germline SDHB-deficiency: case report.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Ugarte-Camara, Marina, Fernandez-Prado, Raul, Lorda, Isabel, Rossello, Gabriela, Gonzalez-Enguita, Carmen, Cannata-Ortiz, Pablo, Ortiz, Alberto

According to WHO, succinate dehydrogenase (SDH)-deficient renal cell carcinoma is characterized by negative immunostaining for SDHB, which remains positive in non-tumor tissue despite germline mutations in the SDHB gene. We now report a patient with a SDHB mutation, c.166_170del (p.Pro56Tyrfs*5) who developed renal cell carcinomas with characteristic morphological features of SDH-deficient renal cell carcinoma but had positive SDHB immunostaining. Within a 6-year period, the patient developed…



Impact of a phone app on nephrology referral.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Oliva-Damaso, Nestor, Oliva-Damaso, Elena, Rivas-Ruiz, Francisco, Lopez, Francisca, Castilla, Maria Del Mar, Baamonde-Laborda, Eduardo, Rodriguez-Perez, Jose Carlos, Payan, Juan

Various factors can lead to inadequate nephrology referral decisions being taken by clinicians, but a major cause is unawareness of guidelines, recommendations and indications, or of appropriate timing. Today, tools such as smartphone applications (Apps) can make this knowledge more accessible to non-nephrologist clinicians. Our study aim is to determine the effectiveness of a purpose-built app in this respect. In a retrospective study, nephrology referrals were compared before and after the…



Knowledge about E-Cigarettes and Tobacco Harm Reduction among Public Health Residents in Europe.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Ferrara, Pietro, Shantikumar, Saran, Cabral Veríssimo, Vítor, Ruiz-Montero, Rafael, Masuet-Aumatell, Cristina, Ramon-Torrell, Josep Maria, EuroNet MRPH Working Group on Electronic Cigarettes and Tobacco Harm Reduction

Although electronic cigarettes (e-cigarettes) and other tobacco-related products are becoming widely popular as alternatives to tobacco, little has been published on the knowledge of healthcare workers about their use. Thus, the aim of this study was to elicit the current knowledge and perceptions about e-cigarettes and tobacco harm reduction (THR) among medical residents in public health (MRPH). A Europe-wide cross-sectional study was carried out amongst MRPH from the countries associated with…



New horizons in management of heart failure in older patients.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Stefil, Maria, Manzano, Luis, Montero-PéRez-Barquero, Manuel, Coats, Andrew J S, Flather, Marcus

Heart failure has a high prevalence in older populations, is a common and growing cause for hospital admission and carries a high risk of morbidity and mortality. Important co-morbidities in older patients with heart failure include atrial fibrillation, renal impairment, hypertension and anaemia. Diagnosing and managing heart failure in older patients are complicated due to atypical presentations, co-morbidities and a relative lack of evidence for commonly used treatments in younger patients.…



Antithrombotic Therapy for Percutaneous Cardiovascular Interventions: From Coronary Artery Disease to Structural Heart Interventions.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Caracciolo, Alessandro, Mazzone, Paolo, Laterra, Giulia, Garcia-Ruiz, Victoria, Polimeni, Alberto, Galasso, Salvatore, Saporito, Francesco, Carerj, Scipione, D'Ascenzo, Fabrizio, Marquis-Gravel, Guillaume, Giustino, Gennaro, Costa, Francesco

Percutaneous cardiovascular interventions have changed dramatically in recent years, and the impetus given by the rapid implementation of novel techniques and devices have been mirrored by a refinement of antithrombotic strategies for secondary prevention, which have been supported by a significant burden of evidence from clinical studies. In the current manuscript, we aim to provide a comprehensive, yet pragmatic, revision of the current available evidence regarding antithrombotic strategies…



Body Composition Changes Following a Concurrent Exercise Intervention in Perimenopausal Women: The FLAMENCO Project Randomized Controlled Trial.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Coll-Risco, Irene, Acosta-Manzano, Pedro, Borges-Cosic, Milkana, Camiletti-Moiron, Daniel, Aranda, Pilar, Soriano-Maldonado, Alberto, Aparicio, Virginia A

We assessed the effects of a 16-week primary-care-based exercise program on body composition in perimenopausal women. The women (n = 150) were randomized into control (n = 75) or exercise (n = 75) groups. Exercise was provided in a 16-week (60 min/session, 3 days/week) concurrent program. Body composition was measured using dual-energy X-ray absorptiometry. These are secondary analyses of the FLAMENCO Project (Clinical Trials Reference NCT02358109). In the intention-to-treat analyses, the…



Impact of KPC Production and High-Level Meropenem Resistance on All-Cause Mortality of Ventilator-Associated Pneumonia in Association with Klebsiella pneumoniae.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Rivera-Espinar, Francisco, Machuca, Isabel, Tejero, Rocio, Rodríguez, Jorge, Mula, Ana, Marfil, Eduardo, Cano, Ángela, Gutiérrez-Gutiérrez, Belén, Rodríguez, Marina, Pozo, Juan Carlos, De la Fuente, Carmen, Rodriguez-Baño, Jesús, Martínez-Martínez, Luis, León, Rafael, Torre-Cisneros, Julian

Carbapenemase-producing Enterobacterales and specifically Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) are rapidly spreading worldwide. The prognosis of ventilator-associated pneumonia (VAP) caused by KPC-Kp is not well known. Our study tries to assess whether ventilator-associated pneumonia caused by a KPC-Kp strain is associated with higher all-cause mortality than that caused by carbapenem-susceptible isolates. This is a retrospective cohort study of…



Normal-Weight Obesity Is Associated with Increased Cardiometabolic Risk in Young Adults.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Correa-Rodríguez, María, González-Ruíz, Katherine, Rincón-Pabón, David, Izquierdo, Mikel, García-Hermoso, Antonio, Agostinis-Sobrinho, Cesar, Sánchez-Capacho, Nohora, Roa-Cubaque, Marcela América, Ramírez-Vélez, Robinson

Normal-weight obesity (NWO) has been shown to be associated with cardiometabolic dysfunction. However, little is known regarding this potential relationship in early adulthood. The aim of this study was to investigate the associations between NWO and cardiometabolic risk factors in a large population of Colombian young adults. A cross-sectional study was conducted on 1354 subjects (61% women), aged from 18 to 30. Anthropometric data, including body mass index (BMI) and waist circumference (WC…



Listeria monocytogenes, a rare cause of endophthalmitis.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Martin Hita, L, Casanovas Moreno-Torre, I, Molina Esteban, J, Foronda García-Hidalgo, C, Guillot Suay, V, Navarro Mari, J M




Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson's Disease-Associated Pathology.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Edwards Iii, George, Gamez, Nazaret, Armijo, Enrique, Kramm, Carlos, Morales, Rodrigo, Taylor-Presse, Kathleen, Schulz, Paul E, Soto, Claudio, Moreno-Gonzalez, Ines

: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute to this cell death are inflammation, oxidative stress, and misfolded alpha-synuclein-induced toxicity. Current treatments are effective at managing the early motor symptoms of the disease, but they become ineffective over time and lead to adverse effects. Previous…



Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: the CONTROL trial.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Barcenas, C H, Hurvitz, S A, Di Palma, J A, Bose, R, Chien, A J, Iannotti, N, Marx, G, Brufsky, A, Litvak, A, Ibrahim, E, Alvarez, R H, Ruiz-Borrego, M, Chan, N, Manalo, Y, Kellum, A, Trudeau, M, Thirlwell, M, Garcia Saenz, J, Hunt, D, Bryce, R, McCulloch, L, Rugo, H S, Tripathy, D, Chan, A, CONTROL Study Investigators

Neratinib is an irreversible pan-HER tyrosine kinase inhibitor approved for extended adjuvant treatment in early-stage HER2-positive breast cancer based on the phase III ExteNET study. In that trial, in which no antidiarrheal prophylaxis was mandated, grade 3 diarrhea was observed in 40% of patients and 17% discontinued due to diarrhea. The international, open-label, sequential-cohort, phase II CONTROL study is investigating several strategies to improve tolerability. Patients who completed…



SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Costela-Ruiz, Víctor J, Illescas-Montes, Rebeca, Puerta-Puerta, Jose M, Ruiz, Concepción, Melguizo-Rodríguez, Lucia

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients…



Cardiovascular Risk Prediction in Ankylosing Spondylitis: From Traditional Scores to Machine Learning Assessment.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Navarini, Luca, Caso, Francesco, Costa, Luisa, Currado, Damiano, Stola, Liliana, Perrotta, Fabio, Delfino, Lorenzo, Sperti, Michela, Deriu, Marco A, Ruscitti, Piero, Pavlych, Viktoriya, Corrado, Addolorata, Di Benedetto, Giacomo, Tasso, Marco, Ciccozzi, Massimo, Laudisio, Alice, Lunardi, Claudio, Cantatore, Francesco Paolo, Lubrano, Ennio, Giacomelli, Roberto, Scarpa, Raffaele, Afeltra, Antonella

The performance of seven cardiovascular (CV) risk algorithms is evaluated in a multicentric cohort of ankylosing spondylitis (AS) patients. Performance and calibration of traditional CV predictors have been compared with the novel paradigm of machine learning (ML). A retrospective analysis of prospectively collected data from an AS cohort has been performed. The primary outcome was the first CV event. The discriminatory ability of the algorithms was evaluated using the area under the receiver…



Emerging roles of non-coding RNAs in vector-borne infections.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Bensaoud, Chaima, Martins, Larissa Almeida, Aounallah, Hajer, Hackenberg, Michael, Kotsyfakis, Michail

Non-coding RNAs (ncRNAs) are nucleotide sequences that are known to assume regulatory roles previously thought to be reserved for proteins. Their functions include the regulation of protein activity and localization and the organization of subcellular structures. Sequencing studies have now identified thousands of ncRNAs encoded within the prokaryotic and eukaryotic genomes, leading to advances in several fields including parasitology. ncRNAs play major roles in several aspects of vector-host-…



Tocilizumab as a possible cause of ischemic colitis., Tocilizumab como posible causa de colitis isquémica.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Forneiro Pérez, Rocío, Dabán López, Pablo, Zurita Saavedra, María Sol, Hernández García, María Dolores, Mirón Pozo, Benito




How is the duodenal mucosa in functional dyspepsia?

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Caballero-Mateos, Antonio Mª, Caballero Plasencia, M Rosa

Gastric mucosa has been widely studied during the pre/post-Helicobacter pylori (Hp) era. Excluding peptic ulcer disease (PUD), the duodenal mucosa has not been thoroughly analyzed, even less so in functional dyspepsia (FD). We would like to make some comments after studying 161 dyspeptic patients with samples taken from the gastric body, antrum, proximal and distal duodenum.



Real-world data of fulvestrant as first-line treatment of postmenopausal women with estrogen receptor-positive metastatic breast cancer.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Blancas, I, Olier, C, Conde, V, Bayo, J L, Herrero, C, Zarcos-Pedrinaci, I, Carabantes, F, Baena-Cañada, J M, Cruz, J, Ruiz-Borrego, M

Goals of endocrine therapy for advanced breast cancer (ABC) include prolonging survival rates, maintaining the quality of life, and delaying the initiation of chemotherapy. We evaluated the effectiveness of fulvestrant as first-line in patients with estrogen receptor (ER)-positive ABC with relapse during or after adjuvant anti-estrogenic therapy in real-world settings. Retrospective, observational study involving 171 postmenopausal women with ER-positive ABC who received fulvestrant as first-…



1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Sønderby, Ida E, van der Meer, Dennis, Moreau, Clara, Kaufmann, Tobias, Walters, G Bragi, Ellegaard, Maria, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Micael, Armstrong, Nicola J, Bernard, Manon, Blackburn, Nicholas B, Blangero, John, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Bülow, Robin, Bøen, Rune, Cahn, Wiepke, Calhoun, Vince D, Caspers, Svenja, Ching, Christopher R K, Cichon, Sven, Ciufolini, Simone, Crespo-Facorro, Benedicto, Curran, Joanne E, Dale, Anders M, Dalvie, Shareefa, Dazzan, Paola, de Geus, Eco J C, de Zubicaray, Greig I, de Zwarte, Sonja M C, Desrivieres, Sylvane, Doherty, Joanne L, Donohoe, Gary, Draganski, Bogdan, Ehrlich, Stefan, Eising, Else, Espeseth, Thomas, Fejgin, Kim, Fisher, Simon E, Fladby, Tormod, Frei, Oleksandr, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Ge, Tian, Glahn, David C, Grabe, Hans J, Groenewold, Nynke A, Gústafsson, Ómar, Haavik, Jan, Haberg, Asta K, Hall, Jeremy, Hashimoto, Ryota, Hehir-Kwa, Jayne Y, Hibar, Derrek P, Hillegers, Manon H J, Hoffmann, Per, Holleran, Laurena, Holmes, Avram J, Homuth, Georg, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E, Ikeda, Masashi, Jahanshad, Neda, Jockwitz, Christiane, Johansson, Stefan, Jönsson, Erik G, Jørgensen, Niklas R, Kikuchi, Masataka, Knowles, Emma E M, Kumar, Kuldeep, Le Hellard, Stephanie, Leu, Costin, Linden, David E J, Liu, Jingyu, Lundervold, Arvid, Lundervold, Astri Johansen, Maillard, Anne M, Martin, Nicholas G, Martin-Brevet, Sandra, Mather, Karen A, Mathias, Samuel R, McMahon, Katie L, McRae, Allan F, Medland, Sarah E, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Modenato, Claudia, Sánchez, Jennifer Monereo, Morris, Derek W, Mühleisen, Thomas W, Murray, Robin M, Nielsen, Jacob, Nordvik, Jan E, Nyberg, Lars, Loohuis, Loes M Olde, Ophoff, Roel A, Owen, Michael J, Paus, Tomas, Pausova, Zdenka, Peralta, Juan M, Pike, G Bruce, Prieto, Carlos, Quinlan, Erin B, Reinbold, Céline S, Marques, Tiago Reis, Rucker, James J H, Sachdev, Perminder S, Sando, Sigrid B, Schofield, Peter R, Schork, Andrew J, Schumann, Gunter, Shin, Jean, Shumskaya, Elena, Silva, Ana I, Sisodiya, Sanjay M, Steen, Vidar M, Stein, Dan J, Strike, Lachlan T, Suzuki, Ikuo K, Tamnes, Christian K, Teumer, Alexander, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, Uhlmann, Anne, Ulfarsson, Magnus O, van 't Ent, Dennis, van den Bree, Marianne B M, Vanderhaeghen, Pierre, Vassos, Evangelos, Wen, Wei, Wittfeld, Katharina, Wright, Margaret J, Agartz, Ingrid, Djurovic, Srdjan, Westlye, Lars T, Stefansson, Hreinn, Stefansson, Kari, Jacquemont, Sébastien, Thompson, Paul M, Andreassen, Ole A, ENIGMA-CNV working group

Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers display a high prevalence of micro- and macrocephaly in deletion and duplication carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs in 38 cohorts from the large-scale ENIGMA-CNV collaboration and the UK…



Supervised Exercise Immediately After Bariatric Surgery: the Study Protocol of the EFIBAR Randomized Controlled Trial.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Artero, Enrique G, Ferrez-Márquez, Manuel, Torrente-Sánchez, María José, Martínez-Rosales, Elena, Carretero-Ruiz, Alejandro, Hernández-Martínez, Alba, López-Sánchez, Laura, Esteban-Simón, Alba, Romero Del Rey, Andrea, Alcaraz-Ibáñez, Manuel, Rodríguez-Pérez, Manuel A, Villa-González, Emilio, Barranco-Ruiz, Yaira, Martínez-Forte, Sonia, Castillo, Carlos, Gómez Navarro, Carlos, Aceituno Cubero, Jesús, Reyes Parrilla, Raúl, Aparicio Gómez, José A, Femia, Pedro, Fernández-Alonso, Ana M, Soriano-Maldonado, Alberto

Previous studies have investigated weight loss caused by exercise following bariatric surgery. However, in most cases, the training program is poorly reported; the exercise type, volume, and intensity are briefly mentioned; and the sample size, selection criteria, and follow-up time vary greatly across studies. The EFIBAR study aims to investigate over 1 year the effects of a 16-week supervised exercise program, initiated immediately after bariatric surgery, on weight loss (primary outcome),…



One-Year, Efficacy and Safety Open Label Study, with a Single Injection of a New Hyaluronan for Knee OA: The SOYA Trial.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Gavín, Carlos, J Blanco, Francisco, L Pablos, José, Caracuel, Miguel A, Rosas, José, Gómez-Barrena, Enrique, Navarro, Francisco, Coronel, María Pilar, Gimeno, Mercedes

To assess the efficacy and safety of a single injection of a new formulation of hyaluronic acid (MPS-HA2%) in patients with symptomatic knee osteoarthritis after 12 months' follow-up. Prospective, single-arm, multicentre, open-label, 12-month follow-up study. Patients with Kellgren-Lawrence (KL) 2-3 and visual analogue scale (VAS) pain scores of ≥40- A total of 101 patients (mean age: 68 years; 74% female; and 78% overweight) were included. The mean reduction in pain at 12 months was 37.7…



The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Shakur, Haleema, Andrews, Peter, Asser, Toomas, Balica, Laura, Boeriu, Cristian, Ciro Quintero, Juan Diego, Dewan, Yashbir, Druwé, Patrick, Fletcher, Olivia, Frost, Chris, Hartzenberg, Bennie, Mejia Mantilla, Jorge, Murillo-Cabezas, Francisco, Pachl, Jan, Ravi, Ramalingam R, Rätsep, Indrek, Sampaio, Cristina, Singh, Manmohan, Svoboda, Petr, Roberts, Ian

BACKGROUND Cerebral oedema is associated with significant neurological damage in patients with traumatic brain injury. Bradykinin is an inflammatory mediator that may contribute to cerebral oedema by increasing the permeability of the blood-brain barrier. We evaluated the safety and effectiveness of the non-peptide bradykinin B2 receptor antagonist Anatibant in the treatment of patients with traumatic brain injury. During the course of the trial, funding was withdrawn by the sponsor. METHODS…



Making clinical decisions based on measurable residual disease improves the outcome in multiple myeloma.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Martinez-Lopez, Joaquin, Alonso, Rafael, Wong, Sandy W, Rios, Rafael, Shah, Nina, Ruiz-Heredia, Yanira, Sanchez-Pina, Jose Maria, Sanchez, Ricardo, Bahri, Natasha, Zamanillo, Irene, Poza, Maria, Buenache, Natalia, Encinas, Cristina, Juarez, Luis, Miras, Fatima, Collado, Luis, Barrio, Santiago, Martin, Thomas, Cedena, Maria Teresa, Wolf, Jeffrey

The assessment of measurable residual disease (MRD) in bone marrow has proven of prognostic relevance in patients with multiple myeloma (MM). Nevertheless, and unlike other hematologic malignancies, the use of MRD results to make clinical decisions in MM has been underexplored to date. In this retrospective study, we present the results from a multinational and multicenter series of 400 patients with MRD monitoring during front-line therapy with the aim of exploring how clinical decisions made…



Trajectories of alcohol consumption during life and the risk of developing breast cancer.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Donat-Vargas, Carolina, Guerrero-Zotano, Ángel, Casas, Ana, Baena-Cañada, José Manuel, Lope, Virginia, Antolín, Silvia, Garcia-Saénz, José Ángel, Bermejo, Begoña, Muñoz, Montserrat, Ramos, Manuel, de Juan, Ana, Jara Sánchez, Carlos, Sánchez-Rovira, Pedro, Antón, Antonio, Brunet, Joan, Gavilá, Joaquín, Salvador, Javier, Arriola Arellano, Esperanza, Bezares, Susana, Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Martín, Miguel, Pollán, Marina

Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption…



Foetus in foetu versus foetifornn teratonna

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Ruiz Catena, Manuel Jesus, Ruiz Orpez, Antonio, Unda Freire, Alejandro




Ethical attitudes of intensive care paediatricians as regards patients with spinal muscular atrophy type 1

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Agra Tunas, Maria Carmen, Hernandez Rastrollo, Ramon, Hernandez Gonzalez, Arturo, Ramil Fraga, Carmen, Cambra Lasaosa, Francisco Jose, Quintero Otero, Sebastian, Ruiz Extremera, Angela, Rodriguez Nunez, Antonio

Introduction: Spinal muscular atrophy type 1 (SMA-1) is a progressive and fatal disease that leads to ethical problems for Paediatric professionals. Our objective was to determine the ethical options of Paediatric Intensive Care Unit (PICU) paediatricians as regards a child with SMA-1 and respiratory failure. Material and methods: A cross-sectional descriptive study was conducted using an anonymous questionnaire sent to PICUs in Spain (which can be accessed through the Spanish Society of…



Salvage Therapy with CeftolozaneTazobactam for Multidrug-Resistant Pseudomonas aeruginosa Infections

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Jose Caston, Juan, De la Torre, Alvaro, Ruiz-Camps, Isabel, Luisa Sorli, Maria, Torres, Vicente, Torre-Cisneros, Julian

Infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRPA) present a major problem for therapeutic management. We report here our experience with 12 patients with a severe MDRPA infection (6 of which were pneumonia) who received salvage therapy with ceftolozane-tazobactam after inappropriate empirical treatment and/or suboptimal targeted treatment. Although 10 of the 12 patients (83.3%) experienced septic shock, only 3 patients (25%) died during the follow-up period.…



Analysis of the relationship between coexpression domains and chromatin 3D organization

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Soler-Oliva, Maria E., Guerrero-Martinez, Jose A., Bachetti, Valentina, Reyes, Jose C.

Gene order is not random in eukaryotic chromosomes, and co-regulated genes tend to be clustered. The mechanisms that determine co-regulation of large regions of the genome and its connection with chromatin three-dimensional (3D) organization are still unclear however. Here we have adapted a recently described method for identifying chromatin topo-logically associating domains (TADs) to identify coexpression domains (which we term "CODs"). Using human normal breast and breast cancer…



Fendrix(R) Vaccine Effectiveness in Healthcare Workers Who Are Non-Responsive to Engerix B(R) Vaccination

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Jose Tejada-Perez, Juan, Jose Vazquez-Vicente, Juan, Renee Herrera-Burgos, Maria, Gabriel Martin-Martin, Francisco, Parron-Carreno, Tesifon, Alarcon-Rodriguez, Raquel

Hepatitis B (HBV) is a pathogen virus with transmission mechanisms that include contact with the infected blood or bodily fluids of the infected organism. Nowadays, healthcare workers are one of the most exposed groups to HBV. Conventionally, completing a vaccine series dosage with Engerix B(R) lowers this risk by providing workers with immunity to the virus. However, through the years, we have encountered nonresponsive health personnel to the Engerix B(R) vaccine; hence, the Occupational…



Cognitive Representations of Diabetes and their Role in Metabolic Control and Health: When a Positive View of Illness Protects

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
De los Santos-Roiga, Macarena, Ruiz-Gonzalez, Isabel, Robles-Ortega, Humbelina, Perez-Melendez, Cristino

A positive cognitive illness representation (CIR) of diabetes is associated with better metabolic control and health. The aims of this research were to assess CIR with a newly developed Spanish scale - the ERCE - and to predict metabolic control, health outcomes, and psychological distress. One hundred and fifty-two Type 1 diabetic patients were all administered the ERCE, the MOS SF-36, the PANAS, and the HADS scales. Data on glycated hemoglobin (HbAlc) were also collected. Scores on the ERCE…



Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Fielding, Claire, García-García, Andrés, Korn, Claudia, Gadomski, Stephen, Fang, Zijian, Reguera, Juan L, Pérez-Simón, José A, Göttgens, Berthold, Méndez-Ferrer, Simón

The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving haematopoietic stem cell quiescence and maintenance under proliferative stress remain largely unknown. Here we found that cholinergic signals preserve haematopoietic stem cell quiescence in bone-associated (endosteal) bone marrow niches. Bone marrow cholinergic neural signals increase during stress haematopoiesis…



Cycling area can be a confounder and effect modifier of the association between helmet use and cyclists' risk of death after a crash.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Molina-Soberanes, Daniel, Martínez-Ruiz, Virginia, Gordo, Daniel Águila, Martín-delosReyes, Luis Miguel, Rivera-Izquierdo, Mario, Lardelli-Claret, Pablo

The effect of helmet use on reducing the risk of death in cyclists appears to be distorted by some variables (potential confounders, effect modifiers, or both). Our aim was to provide evidence for or against the hypothesis that cycling area may act as a confounder and effect modifier of the association between helmet use and risk of death of cyclists involved in road crashes. Data were analysed for 24,605 cyclists involved in road crashes in Spain. A multiple imputation procedure was used to…



Pharmacist-led antimicrobial stewardship programme in a small hospital without infectious diseases physicians.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Cantudo-Cuenca, María Rosa, Jiménez-Morales, Alberto, Martínez-de la Plata, Juan Enrique

Pharmacists may be tasked to lead antibiotic stewardship programmes (ASP) implementation in small hospitals in absence of infectious diseases (ID) physicians. The objectives are to evaluate the effectiveness of a pharmacist-led ASP in a hospital without ID physician support, with special focus on indicators of the hospital use of antimicrobial agents based on consumption and asess the potential clinical and economic impact of pharmacist interventions (PIs) through the CLEO tool. A prospective…



Semaglutide in type 2 diabetes with chronic kidney disease at high risk progression-real-world clinical practice.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Aviles Bueno, Beatriz, Soler, Maria Jose, Perez-Belmonte, Luis, Jimenez Millan, Anabel, Rivas Ruiz, Francisco, Garcia de Lucas, Maria Dolores

Semaglutide [glucagon-like peptide-1 receptor-agonist (GLP-1RA)] has shown nephroprotective effects in previous cardiovascular studies. However, its efficacy and safety in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) have been rarely studied. This is a multicenter, retrospective, observational study in patients with T2D and CKD with glycosylated hemoglobin A1c (HbA1c) of 7.5-9.5% treated with subcutaneous semaglutide for 12 months in real-world clinical practice. The…



Aspectos innovadores en la atención al maltrato infantil

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Gil Arrones, Juan M.

La atención al Maltrato Infantil (MI) en nuestro país ha mejorado en los últimos años por la suma de diferentes factores: a. La evolución en el propio concepto y el conocimiento del problema. b. La conciencia social que se ha generado en torno al MI. c. La disponibilidad de un marco legislativo y de recursos adecuados.



Anti-hyperglycemic and antioxidant effect of fucoidan extract from Lessonia trabeculata in alloxan-induced diabetes rats

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Teresa Loayza-Gutierrez, Lillyan, Valdir Apumayta-Suarez, Eder, Abdala, Roberto, Angel Aguilar-Mendoza, Luis, Antonio Chavez-Perez, Jorge, Decara, Juan

The objective of this research was to evaluate a nutritional strategy based on the consumption of a fucoidan extract from brown algae Lessonia trabeculata to control oxidative stress in experimental alloxan-induced insulin-dependent diabetes mellitus rats. Over 30 days, 75, 100, and 125 mg kg(-1) of body weight of fucoidan doses were administered and both positive and negative control (n = 5 per group). Serum, liver, pancreas, and kidney biochemical indicators of oxidative stress improvement…



Anti-glomerular Basement Membrane Glomerulonephritis: A Study in Real Life.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Sánchez-Agesta, Marina, Rabasco, Cristina, Soler, María J, Shabaka, Amir, Canllavi, Elisabeth, Fernández, Saulo J, Cazorla, Juan M, López-Rubio, Esperanza, Romera, Ana, Barroso, Sergio, Huerta, Ana, Calle, Leonardo, Sierra, Milagros, Domínguez-Torres, Patricia, Moreno-Ramírez, Manuela, Afonso, Sara, Mascarós, Victoria, Coca, Armando, Espinosa, Mario, Spanish Group for the Study of Glomerular Diseases (GLOSEN)

Anti-glomerular basement membrane (anti-GBM) disease is a severe entity with few therapeutic options including plasma exchange and immunosuppressive agents. The aim of this study was to analyze the clinical and pathological features that predict the evolution of end-stage kidney disease (ESKD) and the kidney survival in a cohort of patients with anti-GBM disease with renal involvement in real life. A retrospective multicentre observational study including 72 patients from 18 nephrology…



Different Sources of Mesenchymal Stem Cells for Tissue Regeneration: A Guide to Identifying the Most Favorable One in Orthopedics and Dentistry Applications.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Costela-Ruiz, Victor J, Melguizo-Rodríguez, Lucía, Bellotti, Chiara, Illescas-Montes, Rebeca, Stanco, Deborah, Arciola, Carla Renata, Lucarelli, Enrico

The success of regenerative medicine in various clinical applications depends on the appropriate selection of the source of mesenchymal stem cells (MSCs). Indeed, the source conditions, the quality and quantity of MSCs, have an influence on the growth factors, cytokines, extracellular vesicles, and secrete bioactive factors of the regenerative milieu, thus influencing the clinical result. Thus, optimal source selection should harmonize this complex setting and ensure a well-personalized and…



[Nutrition in palliative care: guidelines from the Working Group on Bioethics, Spanish Society of Clinical Nutrition and Metabolism (SENPE)]., Nutrición en cuidados paliativos: resumen de recomendaciones del Grupo de Trabajo de Ética de la SENPE.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Del Olmo García, M ª Dolores, Moreno Villares, José Manuel, Álvarez Hernández, Julia, Ferrero López, Isabel, Bretón Lesmes, Irene, Virgili Casas, Nuria, Ashbaugh Enguídanos, Rosana, Lozano Fuster, Francisca Margarita, Wanden-Berghe, Carmina, Irles Rocamora, José A, Molina Soria, Juan B, Montejo González, Juan Carlos, Cantón Blanco, Ana

Palliative care provides a holistic approach and care for patients with a terminal illness and their families. In palliative care physical complaints as well as emotional, social and spiritual aspects are considered. Nutritional care should be also considered within palliative support. For those working in the nutritional support field, to withhold or withdraw nutritional support may be an ethical dilemma in this scenario. The controversy starts when considering nutrition and hydration as basic…



Can clinicopathological factors improve the prediction of metastasis to nonsentinel lymph nodes in patients with breast cancer?, ¿Pueden los factores clínicopatológicos mejorar la predicción de metástasis en ganglios linfáticos no centinelas en pacientes con cáncer de mama?

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
García-Mejido, José A, Sánchez-Sevilla, Miguel, González-Martínez, Jesús, Fernández-Palacín, Ana, Sainz-Bueno, José A

To determine whether clinicopathological characteristics can improve the prediction of metastasis to nonsentinel lymph nodes (NSLNs) over the use of only mRNA copy number in sentinel lymph node (SLN) biopsies. This was a retrospective, observational study that included a total of 824 patients with T1-3 breast cancer who had clinically negative, ultrasound-negative axilla without evidence of metastasis and who underwent one-step nucleic acid amplification in SLN biopsies. 118 required a complete…



Critical media attributes in E-beam sterilization of corneal tissue.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Sharifi, Sina, Sharifi, Hannah, Akbari, Ali, Lei, Fengyang, Dohlman, Claes H, Gonzalez-Andrades, Miguel, Guild, Curtis, Paschalis, Eleftherios I, Chodosh, James

When ionizing irradiation interacts with a media, it can form reactive species that can react with the constituents of the system, leading to eradication of bioburden and sterilization of the tissue. Understanding the media's properties such as polarity is important to control and direct those reactive species to perform desired reactions. Using ethanol as a polarity modifier of water, we herein generated a series of media with varying relative polarities for electron beam (E-beam)…



Practical update of the Recommendations Published by the Psoriasis Group of the Spanish Academy of Dermatology and Venereology (GPS) on the Treatment of Psoriasis with Biologic Therapy. Part 1. Concepts and General Management of Psoriasis with Biologic Therapy., Actualización práctica de las recomendaciones del Grupo de Psoriasis de la Academia Española de Dermatología y Venereología (GPS) para el tratamiento de la psoriasis con terapia biológica. Parte 1. «Conceptos y manejo general de la psoriasis con terapia biológica».

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Carrascosa, J M, Puig, L, Belinchón Romero, I, Salgado-Boquete, L, Del Alcázar, E, Andrés Lencina, J J, Moreno, D, de la Cueva, P

A new, updated AEDV Psoriasis Group consensus document on the treatment of moderate to severe psoriasis was needed owing to the approval, in recent years, of a large number of new drugs and changes in the treatment paradigm. The consensus document was developed using the nominal group technique and a scoping review. First, a designated coordinator selected a group of Psoriasis Group members for the panel. The coordinator defined the objectives and key points for the document and, with the help…



Second-line treatment in advanced non-squamous (NS) non-small cell lung cancer (NSCLC) patients in Spain, analyzed in the Thoracic Tumor Registry (RTT)

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Carcereny Costa, E., Collazo Lorduy, A., Cobo Dols, M., Rodriguez Abreu, D., Bernabe Caro, R., Lopez Castro, R., Massuti Sureda, B., del Barco, E., Guirado, M., Bosch-Barrera, J., Gonzalez-Larriba, J. L., Sanchez Hernandez, A., Juan Vidal, O. J., Oramas Rodriguez, J. M., Mosquera Martinez, J., Ortega Granados, A. L. O., Padilla, A., Moran Bueno, M. T., Cantero, A., Provencio Pulla, M.




Enfermedad renal crónica : ¿qué tratamiento me conviene? : herramienta de ayuda para la toma de decisiones

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Hermosilla Gago, Teresa, Quirós Ganga, Pedro Luis, Remón Rodríguez, César, Cuerva Carvajal, Ángela

La Consejería de Salud de la Junta de Andalucía, con la colaboración de un grupo de profesionales liderado por la Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA, ha elaborado esta guía para que sirva como “Herramienta de ayuda a la toma de decisiones en la enfermedad renal crónica avanzada” (ERCA). La guía pretende que los pacientes atendidos en las consultas de pre-diálisis de los diferentes Servicios de Nefrología de los hospitales andaluces tengan la información…



Proactive monitoring of anti-TNF agents improves follow-up of paediatric patients with Crohn disease

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Azor, Begona Rodriguez, Martin-Masot, Rafael, Khialani, Anita Dayaldasani, Fernandez-Martin, Jesus Maria, Fernandez, Carmen Gallego, Navas-Lopez, Victor Manuel

Introduction and aims: The incidence of paediatric inflammatory bowel disease has increased in recent decades. The aim of the present study was to evaluate the role of proactive and serial monitoring of tumour necrosis factor (TNF) inhibitor levels to maintain clinical remission and mucosal healing in the follow-up of paediatric patients with Crohn disease (CD).Method: Prospective study that included all patients diagnosed with CD and treated with adali-mumab or infliximab between May 2015 and…



Overall survival with palbociclib plus endocrine therapy versus capecitabine in postmenopausal patients with hormone receptor-positive, HER2-negative metastatic breast cancer in the PEARL study.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Martín, Miguel, Zielinski, Christoph, Ruiz-Borrego, Manuel, Carrasco, Eva, Ciruelos, Eva M, Muñoz, Montserrat, Bermejo, Begoña, Margelí, Mireia, Csöszi, Tibor, Antón, Antonio, Turner, Nicholas, Casas, María I, Morales, Serafín, Alba, Emilio, Calvo, Lourdes, de la Haba-Rodríguez, Juan, Ramos, Manuel, Murillo, Laura, Santaballa, Ana, Alonso-Romero, José L, Sánchez-Rovira, Pedro, Corsaro, Massimo, Huang, Xin, Thallinger, Christiane, Kahan, Zsuzsanna, Gil-Gil, Miguel

An earlier analysis of the PEARL phase III study showed that palbociclib plus endocrine therapy (ET) does not improve progression-free survival (PFS) over capecitabine in aromatase inhibitor-resistant, hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer (MBC) patients. Here, we report the final overall survival (OS) analysis. Postmenopausal patients (N = 601) were randomized 1:1 to capecitabine or palbociclib plus ET (exemestane, Cohort 1;…



Evaluation of differential effects of metformin treatment in obese children according to pubertal stage and genetic variations: study protocol for a randomized controlled trial.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Pastor-Villaescusa, Belén, Caballero-Villarraso, Javier, Cañete, M Dolores, Hoyos, Raúl, Maldonado, José, Bueno, Gloria, Leis, Rosaura, Gil, Ángel, Cañete, Ramón, Aguilera, Concepción M

BACKGROUND Overweight and obesity are considered to be serious public health problems. In pediatric populations, insulin resistance, dyslipidemia, and hypertension associated with obesity occur with increased frequencies. Metformin is an oral anti-hyperglycemic agent that has been demonstrated to be efficacious in the treatment of diabetic and non-diabetic obese adults. A considerable amount of pharmacogenetic research has demonstrated that genetic variation is one of the major factors…



Capsaicin 8% Patch Repeat Treatment in Non-diabetic Peripheral Neuropathic Pain: A 52-week, Open-label, Single-arm, Safety Study.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Gálvez, Rafael, Navez, Marie-Louise, Moyle, Graeme, Maihöfner, Christian, Stoker, Malcolm, Ernault, Etienne, Nurmikko, Turo J, Attal, Nadine

OBJECTIVES To investigate long-term safety and tolerability of capsaicin 8% patch repeat treatment in non-diabetic patients with peripheral neuropathic pain (NP). METHODS Prospective, open-label, observational study in patients with post-herpetic neuralgia, post-traumatic or post-surgical nerve injury, HIV-associated distal sensory polyneuropathy, or other peripheral NP, and average daily pain score ≥4, received ≤6 capsaicin 8% patch treatments over 52 weeks according to clinical need (…



Cáncer de piel: proceso asistencial integrado. 2ª ed.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Ferrándiz Pulido, Lara, Alcalde Alonso, Mercedes, Armario Hita, José Carlos, Correa Generoso, Raquel, De Troya Martín, Magdalena, Galdeano Reina, Rafael, García Asuero, Catalina, Garnacho Saucedo, Gloria, Lozano Barriuso, Ana, Martínez Pilar, Leandro, Ras Luna, Javier, Ríos Martín, Juan José, Ruiz Carrascosa, José Carlos, Ruiz de Casas, Andrés, Ruiz Villaverde, Ricardo, Sanz Amores, Reyes, Suárez Marrero, María del Carmen, Vallejo Rodríguez, Inmaculada, Zulueta Dorado, Teresa

El Proceso Asistencial Integrado Cáncer de Piel publicado en el año 2002 permitió el establecimiento de las bases para la coordinación entre profesionales de los dos ámbitos asistenciales, Atención Primaria y Hospitalaria, orientada a facilitar y proporcionar una atención precoz y basada en normas de calidad al paciente con sospecha de cáncer de piel. En la versión actual del Proceso Asistencial Integrado Cáncer de Piel debido a las particularidades del carcinoma cutáneo no melanoma y melanoma…



Guía de acceso a la App de Dynamed Plus

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Bibloteca Virtual del Sistema Sanitario Público de Andalucía

Instrucciones que deben seguir los profesionales sanitarios del Sistema Sanitario Público de Andalucía (SSPA) para acceder al recurso DynaMed Plus (Point of Care) a través de dispositivos móviles



Vol. 25, nº 43. Plan de inspección basado en el riesgo de los establecimientos alimentarios de Andalucía 2019

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Servicio de Vigilancia y Salud Laboral

Enfermedades de Declaración Obligatoria por provincias. Semana 42/2020 y acumulado desde semana 1/2020. Datos provisionales. Incluye además el artículo titulado 'Plan de inspección basado en el riesgo de los establecimientos alimentarios de Andalucía 2019', de Dolores Moreno Badillo. Servicio de Seguridad Alimentaria. Consejería de Salud y Familias.



Effects of Biological Therapies on Molecular Features of Rheumatoid Arthritis

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Lopez-Pedrera, Chary, Barbarroja, Nuria, Patiño-Trives, Alejandra M., Luque-Tévar, Maria, Collantes-Estevez, Eduardo, Escudero-Contreras, Alejandro, Pérez-Sánchez, Carlos

Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease primarily affecting the joints, and closely related to specific autoantibodies that mostly target modified self-epitopes. Relevant findings in the field of RA pathogenesis have been described. In particular, new insights come from studies on synovial fibroblasts and cells belonging to the innate and adaptive immune system, which documented the aberrant production of inflammatory mediators, oxidative stress and NETosis,…



Prevalence and resistance mutations of non-B HIV-1 subtypes among immigrants in Southern Spain along the decade 2000-2010.

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
de Felipe, Beatriz, Pérez-Romero, Pilar, Abad-Fernández, María., Fernandez-Cuenca, Felipe, Martinez-Fernandez, Francisco J., Trastoy, Mónica, Mata, Rosario C, López-Cortés, Luis F., Leal, Manuel, Viciana, Pompeyo, Vallejo, Alejandro

Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan Africa and India although they have been found worldwide. In the last decade, immigration from these areas has increased considerably in Spain. The objective of this study was to evaluate the prevalence of non-B subtypes circulating in a cohort of HIV-1-infected immigrants in Seville, Southern Spain and to identify drug resistance-associated mutations. METHODS: Complete protease and first 220 codons of the reverse transcriptase…



Ribavirin as a First Treatment Approach for Hepatitis E Virus Infection in Transplant Recipient Patients

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Rivero-Juarez, Antonio, Vallejo, Nicolau, Lopez-Lopez, Pedro, Díaz-Mareque, Ana Isabel, Frias, Mario, Vallejo, Aldara, Caballero-Gómez, Javier, Rodríguez-Velasco, María, Molina, Esther, Aguilera, Antonio

The hepatitis E virus (HEV) is the major cause of acute hepatitis of viral origin worldwide. Despite its usual course as an asymptomatic self-limited hepatitis, there are highly susceptible populations, such as those with underlying immunosuppression, which could develop chronic hepatitis. In this situation, implementation of therapy is mandatory in the sense to facilitate viral clearance. Currently, there are no specific drugs approved for HEV infection, but ribavirin (RBV), the drug of choice…



Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Fernández-Muñoz, Beatriz, Rosell-Valle, Cristina, Ferrari, Daniela, Alba-Amador, Julia, Montiel, Miguel Ángel, Campos-Cuerva, Rafael, Lopez-Navas, Luis, Muñoz-Escalona, María, Martín-López, María, Profico, Daniela Celeste, Blanco, Manuel Francisco, Giorgetti, Alessandra, González-Muñoz, Elena, Márquez-Rivas, Javier, Sanchez-Pernaute, Rosario

Intraventricular hemorrhage is a common cause of morbidity and mortality in premature infants. The rupture of the germinal zone into the ventricles entails loss of neural stem cells and disturbs the normal cytoarchitecture of the region, compromising late neurogliogenesis. Here we demonstrate that neural stem cells can be easily and robustly isolated from the hemorrhagic cerebrospinal fluid obtained during therapeutic neuroendoscopic lavage in preterm infants with severe intraventricular…



Características clínico-epidemiológicas de la infección por el virus SARS-CoV-2 en médicos de familia: un estudio de casos y controles, Clinical and epidemiological characteristics of SARS-CoV-2 infections in family physicians: A case-control study

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Párraga Martínez, Ignacio, Pérula de Torres, Luis Angel, González Lama, Jesús, Jiménez García, Celia, Sánchez Montero, Rosa, Rider Garrido, Faustino

Objective: To identify the sociodemographic, clinical and epidemiological characteristics asso ciated with the presence of infection by the SARS-CoV-2 virus in family physicians who carry out their work in Primary Care (PC) or in Hospital Emergencies.Desing: Observational analytical case-control study.Site: Primary care.Participants: 969 Primare Care Physicians, Hospital Emergency physicians and other extrahos pitalry centers that had PCR for the detection of the SARS-CoV-2. Of these, 133…, Objetivo: Identificar las características sociodemográficas, clínicas y epidemiológicas asociadas a la presencia de infección por el virus SARS-CoV-2 en médicos de familia que desempenan ˜ su actividad laboral en atención primaria (AP) o en urgencias de hospital. Diseno: ˜ Estudio observacional analítico de casos y controles. Emplazamiento: Atención primaria. Participantes: Un total de 969 médicos de AP, urgencias hospitalarias y otros centros extra hospitalarios que dispusieran de RT-PCR para…



Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Romero-Duarte, Álvaro, Rivera-Izquierdo, Mario, Guerrero-Fernández de Alba, Inmaculada, Pérez-Contreras, Marina, Fernández-Martínez, Nicolás Francisco, Ruiz-Montero, Rafael, Serrano-Ortiz, Álvaro, Ortiz González-Serna, Rocío, Salcedo-Leal, Inmaculada, Jiménez-Mejías, Eladio, Cárdenas-Cruz, Antonio

Background Long-term effects of COVID-19, also called Long COVID, affect more than 10% of patients. The most severe cases (i.e. those requiring hospitalization) present a higher frequency of sequelae, but detailed information on these effects is still lacking. The objective of this study is to identify and quantify the frequency and outcomes associated with the presence of sequelae or persistent symptomatology (SPS) during the 6 months after discharge for COVID-19. Methods Retrospective…



Prevalence and Risk Factors for Multidrug-Resistant Organisms Colonization in Long-Term Care Facilities Around the World: A Review

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Rodríguez-Villodres, Ángel, Martín-Gandul, Cecilia, Peñalva, Germán, Guisado-Gil, Ana Belén, Crespo-Rivas, Juan Carlos, Pachón-Ibáñez, María Eugenia, Lepe, José Antonio, Cisneros, José Miguel

Elderly people confined to chronic care facilities face an increased risk of acquiring infections by multidrug-resistant organisms (MDROs). This review presents the current knowledge of the prevalence and risk factors for colonization by MDROs in long-term care facilities (LTCF), thereby providing a useful reference to establish objectives for implementing successful antimicrobial stewardship programs (ASPs). We searched in PubMed and Scopus for studies examining the prevalence of MDROs and/or…



Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells

Repositorio: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Verdugo-Sivianes, Eva M., Rojas, Ana M., Muñoz-Galván, Sandra, Otero-Albiol, Daniel, Carnero, Amancio

Rationale: SPINOPHILIN (SPN, PPP1R9B) is an important tumor suppressor involved in the progression and malignancy of different tumors depending on its association with protein phosphatase 1 (PP1) and the ability of the PP1-SPN holoenzyme to dephosphorylate retinoblastoma (pRB). Methods: We performed a mutational analysis of SPN in human tumors, focusing on the region of interaction with PP1 and pRB. We explored the effect of the SPN-A566V mutation in an immortalized non-tumorigenic cell line of…