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Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases

Repositorio: Repositori Institucional de la Universitat Rovira i Virgili
Karri, Venkatanaidu; Ramos, David; Bauza Martinez, Julia; Odena, Antonia; Oliveira, Eliandre; Coort, Susan L; Evelo, Chris T; Mariman, Edwin C M; Schuhmacher, Marta; Kumar, Vikas

Chronic exposure to heavy metals such as Pb, As, and MeHg can be associated with an increased risk of developing neurodegenerative diseases. Our in vitro bioassays results showed the potency of heavy metals in the order of Pb < As < MeHg on hippocampal cells. The main objective of this study was combining in vitro label free proteomics and systems biology approach for elucidating patterns of biological response, discovering underlying mechanisms of Pb, As, and MeHg toxicity in hippocampal...