Encontrados 1 resultado(s)
Encontradas 1 página(s)
Encontradas 1 página(s)
Rosiglitazone reverses high fat diet-induced changes in BMAL1 function in muscle, fat, and liver tissue in mice
Repositorio: Repositori Institucional de la Universitat Rovira i Virgili
Ribas-Latre A; Fekry B; Kwok C; Baumgartner C; Shivshankar S; Sun K; Chen Z; Eckel-Mahan K
© 2018, Macmillan Publishers Limited, part of Springer Nature. Objective: Nutrient challenge in the form of a high fat (HF) diet causes a reversible reprogramming of the hepatic circadian clock. This depends in part on changes in the recruitment of the circadian transcription factor BMAL1 to genome targets, though the causes and extent of disruption to hepatic and extra-hepatic BMAL1 are unknown. The objective of the study was to determine whether HF diet-induced alterations in BMAL1 function...