Resultados totales (Incluyendo duplicados): 44820
Encontrada(s) 4482 página(s)
Encontrada(s) 4482 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359610
Dataset. 2021
SUPPLEMENTARY DATA: DETAILS OF THE CONSERVED HAIRPINS OF M. GALLOPROVINCIALIS (MGR), P. FUCATA (PFU), R. PHILIPPINARUM (RPH), S. BROUGHTONII (SBR) AND T. GRANOSA (TGR) FROM DIGGING INTO BIVALVE MIRNAOMES: BETWEEN CONSERVATION AND INNOVATION
- Rosani, Umberto
- Bortoletto, Enrico
- Bai, Chang-Ming
- Novoa, Beatriz
- Figueras Huerta, Antonio
- Venier, Paola
- Fromm, Bastian
5 files, Supplementary data for the article https://doi.org/10.1098/rstb.2020.0165, MGR_conserved_miRNAs.fas.-- PFU_conserved_miRNAs.fas.-- RPH_conserved_miRNAs.fas.-- SBR_conserved_miRNAs.fas.-- TGR_conserved_miRNAs.fas, Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/359610
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359610
HANDLE: http://hdl.handle.net/10261/359610
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359610
PMID: http://hdl.handle.net/10261/359610
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359610
Ver en: http://hdl.handle.net/10261/359610
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359610
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359613
Dataset. 2023
TABLE1_STRUCTURAL AND EVOLUTIONARY INSIGHTS INTO ASTACIN METALLOPEPTIDASES.XLSX [DATASET]
- Gomis-Rüth, F. Xavier
- Stöcker, Walter
The astacins are a family of metallopeptidases (MPs) that has been extensively described from animals. They are multidomain extracellular proteins, which have a conserved core architecture encompassing a signal peptide for secretion, a prodomain or prosegment and a zinc-dependent catalytic domain (CD). This constellation is found in the archetypal name-giving digestive enzyme astacin from the European crayfish Astacus astacus. Astacin catalytic domains span ∼200 residues and consist of two subdomains that flank an extended active-site cleft. They share several structural elements including a long zinc-binding consensus sequence (HEXXHXXGXXH) immediately followed by an EXXRXDRD motif, which features a family-specific glutamate. In addition, a downstream SIMHY-motif encompasses a “Met-turn” methionine and a zinc-binding tyrosine. The overall architecture and some structural features of astacin catalytic domains match those of other more distantly related MPs, which together constitute the metzincin clan of metallopeptidases. We further analysed the structures of PRO-, MAM, TRAF, CUB and EGF-like domains, and described their essential molecular determinants. In addition, we investigated the distribution of astacins across kingdoms and their phylogenetic origin. Through extensive sequence searches we found astacin CDs in > 25,000 sequences down the tree of life from humans beyond Metazoa, including Choanoflagellata, Filasterea and Ichtyosporea. We also found < 400 sequences scattered across non-holozoan eukaryotes including some fungi and one virus, as well as in selected taxa of archaea and bacteria that are pathogens or colonizers of animal hosts, but not in plants. Overall, we propose that astacins originate in the root of Holozoa consistent with Darwinian descent and that the latter genes might be the result of horizontal gene transfer from holozoan donors., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/359613
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359613
HANDLE: http://hdl.handle.net/10261/359613
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359613
PMID: http://hdl.handle.net/10261/359613
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359613
Ver en: http://hdl.handle.net/10261/359613
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359613
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359624
Dataset. 2023
DATASHEET1_STRUCTURAL AND EVOLUTIONARY INSIGHTS INTO ASTACIN METALLOPEPTIDASES.DOCX [DATASET]
- Gomis-Rüth, F. Xavier
- Stöcker, Walter
The astacins are a family of metallopeptidases (MPs) that has been extensively described from animals. They are multidomain extracellular proteins, which have a conserved core architecture encompassing a signal peptide for secretion, a prodomain or prosegment and a zinc-dependent catalytic domain (CD). This constellation is found in the archetypal name-giving digestive enzyme astacin from the European crayfish Astacus astacus. Astacin catalytic domains span ∼200 residues and consist of two subdomains that flank an extended active-site cleft. They share several structural elements including a long zinc-binding consensus sequence (HEXXHXXGXXH) immediately followed by an EXXRXDRD motif, which features a family-specific glutamate. In addition, a downstream SIMHY-motif encompasses a “Met-turn” methionine and a zinc-binding tyrosine. The overall architecture and some structural features of astacin catalytic domains match those of other more distantly related MPs, which together constitute the metzincin clan of metallopeptidases. We further analysed the structures of PRO-, MAM, TRAF, CUB and EGF-like domains, and described their essential molecular determinants. In addition, we investigated the distribution of astacins across kingdoms and their phylogenetic origin. Through extensive sequence searches we found astacin CDs in > 25,000 sequences down the tree of life from humans beyond Metazoa, including Choanoflagellata, Filasterea and Ichtyosporea. We also found < 400 sequences scattered across non-holozoan eukaryotes including some fungi and one virus, as well as in selected taxa of archaea and bacteria that are pathogens or colonizers of animal hosts, but not in plants. Overall, we propose that astacins originate in the root of Holozoa consistent with Darwinian descent and that the latter genes might be the result of horizontal gene transfer from holozoan donors., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/359624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359624
HANDLE: http://hdl.handle.net/10261/359624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359624
PMID: http://hdl.handle.net/10261/359624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359624
Ver en: http://hdl.handle.net/10261/359624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359641
Dataset. 2023
SUPPLEMENTARY DATA FROM TARGETING AGGRESSIVE B-CELL LYMPHOMAS THROUGH PHARMACOLOGICAL ACTIVATION OF THE MITOCHONDRIAL PROTEASE OMA1 [DATASET]
- Schwarzer, Adrián
- Oliveira, Matheus
- Kleppa, Marc-Jens
- Slattery, Scott D.
- Anantha, Andy
- Cooper, Alan
- Hannink, Mark
- Schambach, Axel
- Dörrie, Anneke
- Kotlyarov, Alexey
- Gaestel, Matthias
- Hembrough, Todd
- Levine, Jedd
- Luther, Michael
- Stocum, Michael
- Stiles, Linsey
- Weinstock, David M.
- Liesa, Marc
- Kostura, Matthew J.
Compiled RNAseq data from HCT-116 cells treated with BTM-3528., DLBCL are aggressive, rapidly proliferating tumors that critically depend on the ATF4-mediated integrated stress response (ISR) to adapt to stress caused by uncontrolled growth, such as hypoxia, amino acid deprivation, and accumulation of misfolded proteins. Here, we show that ISR hyperactivation is a targetable liability in DLBCL. We describe a novel class of compounds represented by BTM-3528 and BTM-3566, which activate the ISR through the mitochondrial protease OMA1. Treatment of tumor cells with compound leads to OMA1-dependent cleavage of DELE1 and OPA1, mitochondrial fragmentation, activation of the eIF2α-kinase HRI, cell growth arrest, and apoptosis. Activation of OMA1 by BTM-3528 and BTM-3566 is mechanistically distinct from inhibitors of mitochondrial electron transport, as the compounds induce OMA1 activity in the absence of acute changes in respiration. We further identify the mitochondrial protein FAM210B as a negative regulator of BTM-3528 and BTM-3566 activity. Overexpression of FAM210B prevents both OMA1 activation and apoptosis. Notably, FAM210B expression is nearly absent in healthy germinal center B-lymphocytes and in derived B-cell malignancies, revealing a fundamental molecular vulnerability which is targeted by BTM compounds. Both compounds induce rapid apoptosis across diverse DLBCL lines derived from activated B-cell, germinal center B-cell, and MYC-rearranged lymphomas. Once-daily oral dosing of BTM-3566 resulted in complete regression of xenografted human DLBCL SU-DHL-10 cells and complete regression in 6 of 9 DLBCL patient-derived xenografts. BTM-3566 represents a first-of-its kind approach of selectively hyperactivating the mitochondrial ISR for treating DLBCL., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/359641
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359641
HANDLE: http://hdl.handle.net/10261/359641
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359641
PMID: http://hdl.handle.net/10261/359641
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359641
Ver en: http://hdl.handle.net/10261/359641
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359641
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360107
Dataset. 2022
INCREASING ATMOSPHERIC DUST TRANSPORT TOWARDS THE WESTERN MEDITERRANEAN OVER 1948–2020 [DATASET]
- Salvador, Pedro
- Pey, Jorge
- Pérez, Noemí
- Querol, Xavier
- Artíñano, Begoña
Supplementary Figures (1-10), Tables (1-5), Notes (1-2) and References., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/360107
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360107
HANDLE: http://hdl.handle.net/10261/360107
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360107
PMID: http://hdl.handle.net/10261/360107
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360107
Ver en: http://hdl.handle.net/10261/360107
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360107
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359692
Dataset. 2024
PTYCHODERA FLAVA GENOMICS AND TRANSCRIPTOMICS DATA
- Pérez-Posada, Alberto
- Lin, Che-Yi
- Fan, Tzu-Pei
- Lin, Ching-Yi
- Chen, Yi-Chih
- Gómez-Skarmeta, José Luis
- Yu, Jr-Kai
- Su, Yi-Hsien
- Tena, Juan J.
[Description of methods used for collection/generation of data] ATACseq and RNAseq methodology in different developmental stages, Analysis of the transcriptomes and chromatin accessibility of multiple developmental stages of the indirect-developing hemichordate Ptychodera flava. After the individual analysis of each sample, integration of ATACseq and RNAseq data was performed in order to reconstruct genetic and regulatory networks. These data were also compared to other species, what could shed light on deuterostome evolution., Ministerio de Ciencia e Innovación (grant PID2022-141288NB-I00)., supp_data_01.xlsx supp_data_02.xlsx supp_data_03.xlsx supp_data_04.xlsx supp_data_05.xlsx supp_data_06.xlsx supp_data_07.xlsx supp_data_08.xlsx supp_data_09.bed supp_data_10.tsv supp_data_11.tsv.gz supp_data_12.tsv.gz supp_data_13.xlsx supp_data_14.xlsx supp_data_15.xlsx supp_data_16.xlsx, Peer reviewed
DOI: http://hdl.handle.net/10261/359692
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359692
HANDLE: http://hdl.handle.net/10261/359692
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359692
PMID: http://hdl.handle.net/10261/359692
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359692
Ver en: http://hdl.handle.net/10261/359692
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359692
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359752
Dataset. 2024
EFFECT OF CONNECTIVITY ON THE CARRIER TRANSPORT AND RECOMBINATION DYNAMICS OF PEROVSKITE QUANTUM-DOT NETWORKS [DATASET]
- Tiede, David O.
- Romero-Pérez, Carlos
- Koch, Katherine A.
- Ucer, K. Burak
- Calvo, Mauricio E.
- Srimath Kandada, Ajay Ram
- Galisteo-López, Juan F.
- Míguez, Hernán
Quantum-dot (QD) solids are being widely exploited as a solution-processable technology to develop photovoltaic, light-emission, and photodetection devices. Charge transport in these materials is the result of a compromise between confinement at the individual QD level and electronic coupling among the different nanocrystals in the ensemble. While this is commonly achieved by ligand engineering in colloidal-based systems, ligand-free QD assemblies have recently emerged as an exciting alternative where nanostructures can be directly grown into porous matrices with optical quality as well as control over their connectivity and, hence, charge transport properties. In this context, we present a complete photophysical study comprising fluence- and temperature-dependent timeresolved spectroscopy to study carrier dynamics in ligand-free QD networks with gradually varying degrees of interconnectivity, which we achieve by changing the average distance between the QDs. Analysis of the photoluminescence and absorption properties of the QD assemblies, involving both static and timeresolved measurements, allows us to identify the weight of the different recombination mechanisms, both radiative and nonradiative, as a function of QD connectivity. We propose a picture where carrier diffusion, which is needed for any optoelectronic application and implies interparticle transport, gives rise to the exposure of carriers to a larger defect landscape than in the case of isolated QDs. The use of a broad range of fluences permits extracting valuable information for applications demanding either low- or high-carrier-injection levels and highlighting the relevance of a judicious design to balance recombination and diffusion., HM is thankful for the financial support of the Spanish Ministry of Science and Innovation under grant PID2020-116593RB-I00, funded by MCIN/AEI/10.13039/501100011033, and of the Junta de Andalucía under grant P18-RT-2291 (FEDER/UE). HM, JFGL, and DOT acknowledge financial support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 956270 (Persephone). ARSK acknowledges the start-up funds provided by Wake Forest University and funding from the Center for Functional Materials and the Office of Research and Sponsored Programs at WFU., (Folder > File.txt) Figure 1 Figure_1c(norm. Abs).txt Figure_1d(PL).txt Figure_1e(PLQY).txt Figure 2 Figure_2a (TRPL_raw_bulk).txt Figure_2b (TRPL_raw_30per).txt Figure_2c (TRPL_raw_20per).txt Figure_2d (TRPL_raw_10per).txt Figure_2e (TRPL_raw_5per).txt Figure_2i (TRPL_photon_flux_bulk).txt Figure_2j (TRPL_photon_flux_30per).txt Figure_2k (TRPL_photon_flux_20per).txt Figure_2l (TRPL_photon_flux_10per).txt Figure_2m (TRPL_photon_flux_5per).txt Figure 3 Figure_3a (PLQY_bulk).txt Figure_3b (rel_PLQY_Tdep_30per).txt Figure_3c (rel_PLQY_Tdep_20per).txt Figure_3d (rel_PLQY_Tdep_10per).txt Figure_3e (rel_PLQY_Tdep_5per).txt Figure 4 Figure_4a (30per_norm_PL_80K).txt Figure_4b (5per_norm_PL_80K).txt Figure_4c (30per_TA_77K_N=15d5).csv Figure_4d (5per_TA_77K_N=11d1).csv Figure 5 Figure 5a (30per_GSB_decay).txt Figure 5b (5per_GSB_decay).txt Figure 5c (30per_GSB_decay_derivative).txt Figure 5d (5per_GSB_decay_biexciton_fit_all).txt, Peer reviewed
DOI: http://hdl.handle.net/10261/359752
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359752
HANDLE: http://hdl.handle.net/10261/359752
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359752
PMID: http://hdl.handle.net/10261/359752
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359752
Ver en: http://hdl.handle.net/10261/359752
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359752
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359767
Dataset. 2023
TARGET SELECTION FOR THE DESI PECULIAR VELOCITY SURVEY [DATASET]
- Saulder, Christoph
- Prada, Francisco
Supplementary material to DESI's publication "Target Selection for the DESI Peculiar Velocity Survey" to comply with the data management plan. Material includes datasets to reproduce each figure., Australian Laureate Fellowships - Grant ID: FL180100168 FL180100168 Australian Research Council, Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/359767
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359767
HANDLE: http://hdl.handle.net/10261/359767
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359767
PMID: http://hdl.handle.net/10261/359767
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359767
Ver en: http://hdl.handle.net/10261/359767
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359767
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359761
Dataset. 2023
SUPPLEMENTARY TABLE S3 FROM TARGETING AGGRESSIVE B-CELL LYMPHOMAS THROUGH PHARMACOLOGICAL ACTIVATION OF THE MITOCHONDRIAL PROTEASE OMA1 [DATASET]
- Schwarzer, Adrián
- Oliveira, Matheus
- Kleppa, Marc-Jens
- Slattery, Scott D.
- Anantha, Andy
- Cooper, Alan
- Hannink, Mark
- Schambach, Axel
- Dörrie, Anneke
- Kotlyarov, Alexey
- Gaestel, Matthias
- Hembrough, Todd
- Levine, Jedd
- Luther, Michael
- Stocum, Michael
- Stiles, Linsey
- Weinstock, David M.
- Liesa, Marc
- Kostura, Matthew J.
DLBCL are aggressive, rapidly proliferating tumors that critically depend on the ATF4-mediated integrated stress response (ISR) to adapt to stress caused by uncontrolled growth, such as hypoxia, amino acid deprivation, and accumulation of misfolded proteins. Here, we show that ISR hyperactivation is a targetable liability in DLBCL. We describe a novel class of compounds represented by BTM-3528 and BTM-3566, which activate the ISR through the mitochondrial protease OMA1. Treatment of tumor cells with compound leads to OMA1-dependent cleavage of DELE1 and OPA1, mitochondrial fragmentation, activation of the eIF2α-kinase HRI, cell growth arrest, and apoptosis. Activation of OMA1 by BTM-3528 and BTM-3566 is mechanistically distinct from inhibitors of mitochondrial electron transport, as the compounds induce OMA1 activity in the absence of acute changes in respiration. We further identify the mitochondrial protein FAM210B as a negative regulator of BTM-3528 and BTM-3566 activity. Overexpression of FAM210B prevents both OMA1 activation and apoptosis. Notably, FAM210B expression is nearly absent in healthy germinal center B-lymphocytes and in derived B-cell malignancies, revealing a fundamental molecular vulnerability which is targeted by BTM compounds. Both compounds induce rapid apoptosis across diverse DLBCL lines derived from activated B-cell, germinal center B-cell, and MYC-rearranged lymphomas. Once-daily oral dosing of BTM-3566 resulted in complete regression of xenografted human DLBCL SU-DHL-10 cells and complete regression in 6 of 9 DLBCL patient-derived xenografts. BTM-3566 represents a first-of-its kind approach of selectively hyperactivating the mitochondrial ISR for treating DLBCL., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/359761, https://doi.org/10.20350/digitalCSIC/16344
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359761
HANDLE: http://hdl.handle.net/10261/359761, https://doi.org/10.20350/digitalCSIC/16344
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359761
PMID: http://hdl.handle.net/10261/359761, https://doi.org/10.20350/digitalCSIC/16344
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359761
Ver en: http://hdl.handle.net/10261/359761, https://doi.org/10.20350/digitalCSIC/16344
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359761
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359789
Dataset. 2023
SUPPLEMENTARY TABLE S4 FROM TARGETING AGGRESSIVE B-CELL LYMPHOMAS THROUGH PHARMACOLOGICAL ACTIVATION OF THE MITOCHONDRIAL PROTEASE OMA1 [DATASET]
- Schwarzer, Adrián
- Oliveira, Matheus
- Kleppa, Marc-Jens
- Slattery, Scott D.
- Anantha, Andy
- Cooper, Alan
- Hannink, Mark
- Schambach, Axel
- Dörrie, Anneke
- Kotlyarov, Alexey
- Gaestel, Matthias
- Hembrough, Todd
- Levine, Jedd
- Luther, Michael
- Stocum, Michael
- Stiles, Linsey
- Weinstock, David M.
- Liesa, Marc
- Kostura, Matthew J.
Gene level data for Venn Diagram figure of Cell line screening data, DLBCL are aggressive, rapidly proliferating tumors that critically depend on the ATF4-mediated integrated stress response (ISR) to adapt to stress caused by uncontrolled growth, such as hypoxia, amino acid deprivation, and accumulation of misfolded proteins. Here, we show that ISR hyperactivation is a targetable liability in DLBCL. We describe a novel class of compounds represented by BTM-3528 and BTM-3566, which activate the ISR through the mitochondrial protease OMA1. Treatment of tumor cells with compound leads to OMA1-dependent cleavage of DELE1 and OPA1, mitochondrial fragmentation, activation of the eIF2α-kinase HRI, cell growth arrest, and apoptosis. Activation of OMA1 by BTM-3528 and BTM-3566 is mechanistically distinct from inhibitors of mitochondrial electron transport, as the compounds induce OMA1 activity in the absence of acute changes in respiration. We further identify the mitochondrial protein FAM210B as a negative regulator of BTM-3528 and BTM-3566 activity. Overexpression of FAM210B prevents both OMA1 activation and apoptosis. Notably, FAM210B expression is nearly absent in healthy germinal center B-lymphocytes and in derived B-cell malignancies, revealing a fundamental molecular vulnerability which is targeted by BTM compounds. Both compounds induce rapid apoptosis across diverse DLBCL lines derived from activated B-cell, germinal center B-cell, and MYC-rearranged lymphomas. Once-daily oral dosing of BTM-3566 resulted in complete regression of xenografted human DLBCL SU-DHL-10 cells and complete regression in 6 of 9 DLBCL patient-derived xenografts. BTM-3566 represents a first-of-its kind approach of selectively hyperactivating the mitochondrial ISR for treating DLBCL., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/359789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359789
HANDLE: http://hdl.handle.net/10261/359789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359789
PMID: http://hdl.handle.net/10261/359789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359789
Ver en: http://hdl.handle.net/10261/359789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/359789
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