BUSCADOR RECOLECTA

On behalf of the HELENA project group., Objectives To examine the association of health-related physical fitness components and accurate measures of fatness with attention in European adolescents. Design Cross-sectional study. Methods A sub-sample of 444 adolescents from the HELENA study (14.5 ± 1.2 years) from 6 different countries participated in this study. Adolescents underwent evaluations of fitness (20 m shuttle run, handgrip strength, standing long jump and 4 × 10 m shuttle run tests), fatness (body mass index, skinfold thicknesses, bioelectrical impedance, Bod Pod and dual-energy X-ray absorptiometry) and attention (d2-test). Results Higher cardiorespiratory fitness was positively associated with better attention capacity (β = 0.1, p = 0.03). Body mass index and fat mass index measured by Bod Pod and dual-energy X-ray absorptiometry in a subset were negatively associated with attention (β = −0.11, p = 0.02; β = −0.36, p = 0.02; β = −0.34, p = 0.03; respectively). All models were adjusted for age, sex, family-affluence scale and mother education. When these models were additionally adjusted for cardiorespiratory fitness when fatness was the main predictor and vice versa, the associations were somewhat attenuated and were no longer statistically significant. Muscular strength, speed-agility and body fatness markers measured by bioelectrical impedance and skinfolds were not associated with attention. The fit and non-overweight adolescents presented the highest values of attention capacity whilst their unfit and overweight peers showed the lowest values of attention (47.31 ± 2.34 vs. 33.74 ± 4.39; p < 0.01). Conclusions Our results support that both cardiorespiratory fitness and fatness are associated with attention, yet these associations are not independent. A combined effect was also observed, with fit and non-overweight adolescents showing the highest levels of attention and those unfit and overweight the lowest., The HELENA Study was carried out with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and of the Stockholm County Council. FBO and JRR are supported by grants from the Spanish Ministry of Science and Innovation (RYC-2011-09011 and RYC-2010-05957, respectively). CCS is supported by grants from the University of Granada and Spanish Ministry of Economy and Competitiveness (FPU2013/55, BES-2014-068829). In addition, this study takes place under the umbrella of the ActiveBrains project, funded by the Spanish Ministry of Economy and Competitiveness (Ref. DEP2013-47540); and it was further supported by the SAMID III network, RETICS, funded by the PN I+D+I 2017-2021 (Spain), ISCIII- Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF) (Ref. RD16/0022). This work is part of a Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain., Peer Reviewed

On behalf of the HELENA study group., [Background and aims] Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. [Methods and results] A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. [Results] Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. [Conclusions] Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently., The HELENA Study was supported by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and the Stockholm County Council. This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) and the gs4:European Regional Development Fund (FEDER). CCS is supported by the Spanish Ministry of Economy and Competitiveness (BES-2014-068829). FBO is supported by a grant from the Spanish Ministry of Science and Innovation (RYC-2011-09011). AIR was funded by a Juan de la Cierva-Formación stipend from the Ministry of Economy and Competitiveness of the Spanish Government (FJCI-2014-19795)., Peer Reviewed