BACTERIAS MAGNETOTACTICAS COMO GENERADORAS DE NANOPARTICULAS MAGNETICAS MODELO Y BIO-ROBOTS PARA TERAPIAS ESPECIFICAS
MAT2017-83631-C3-2-R
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Nombre agencia financiadora Agencia Estatal de Investigación
Acrónimo agencia financiadora AEI
Programa Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Subprograma Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Convocatoria Retos Investigación: Proyectos I+D+i
Año convocatoria 2017
Unidad de gestión Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Centro beneficiario FUNDACION BCMATERIALS-BASQUE CENTER FOR MATERIALS, APPLICATIONS AND NANOSTRUCTURES
Identificador persistente http://dx.doi.org/10.13039/501100011033
Publicaciones
Found(s) 7 result(s)
Found(s) 1 page(s)
Found(s) 1 page(s)
Effect of Cu substitution on the magnetic and magnetic induction heating response of CdFe₂O₄ spinel ferrite
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Ghasemi, R.
- Echeverría Morrás, Jesús
- Pérez de Landazábal Berganzo, José Ignacio
- Beato López, Juan Jesús
- Naseri, M.
- Gómez Polo, Cristina
In this work, a comparative study of the effect of Cu on the structural, magnetic and magnetic induction heating response in CdFe2O4 spinel is presented. The ceramic nanoparticles (Cu1−xCdxFe2O4; 0 ≤ x ≤ 1) were synthesized by co-precipitation from Cu(II), Cd(II) and Fe(III) salts. The samples, characterized by X-ray diffractometry, display the characteristic spinel cubic structure (space group Fm3m) where CdO is detected as main secondary phase (≈ 16% weight for x = 1). A high degree of nanoparticle agglomeration is inferred from the Transmission Electron Microscopy (TEM) images, as a consequence of the employed synthesis procedure. Regarding the magnetic properties, superparamagnetic behavior at room temperature can be disregarded according to the low field magnetization response (ZFC-FC curves). For 0.4 ≤ x ≤ 0.8 ratios, the samples display maximum values in the magnetic moment that should be correlated to the cation distribution between the octahedral and tetrahedral sites. Maximum magnetization values lead to an enhancement in the magnetic induction heating response characterized by highest heating temperatures under the action of an ac magnetic field. In particular, maximum SAR values are estimated for x = 0.8 as a combined effect of high magnetic moment, low dc coercive field (high susceptibility). Although these Cu-Cd ferrite nanoparticles display moderate SAR values (around 0.7 W/g), the control of the maximum heating temperatures through the cation distribution (composition) provides promising properties to be used as nanosized heating elements (i.e. hyperthermia agents)., The work has been performed within the framework of projects MAT2017-83631-C3-2-R (Spanish 'Ministerio de Ciencia, Innovación y Universidades') and DRUG-MAG, Nueva generación de plataformas teragnósticas contra el cáncer asistidas por partículas superparamagnéticas (Gobierno de Navarra, Departamento de Desarrollo Económico). R. Ghasemi acknowledges the Iranian Ministry of Science, Research and Technology for the financial support at the Universidad Pública de Navarra.
Tailoring the structural and magnetic properties of Co-Zn nanosized ferrites for hyperthermia applications
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Gómez Polo, Cristina
- Recarte Callado, Vicente
- Cervera Gabalda, Laura María
- Beato López, Juan Jesús
- López García, Javier
- Rodríguez Velamazán, José Alberto
- Ugarte Martínez, María Dolores
- Mendonça, E. C.
- Duque, J. G. S.
A comparative study of the magnetic properties (magnetic moment, magnetocrystalline anisotropy) and hyperthermia response in Co-Zn spinel nanoparticles is presented. The CoxZn1-xFe2O4 nanoparticles (x = 1, 0.5, 0.4, 0.3, 0.2 and 0.1) were synthesized by co-precipitated method and the morphology and mean crystallite size (around 10 nm) of the nanoparticles were analysed by TEM Microscopy. Regarding the magnetic characterization (SQUID magnetometry), Co-Zn nanoparticles display at room temperature anhysteretic magnetization curves, characteristic of the superparamagnetic behavior. A decrease in the blocking temperature, T-B, with Zn content is experimentally detected that can be ascribed to the reduction in the mean nanoparticle size as x decreases. Furthermore, the reduction in the magnetocrystalline anisotropy with Zn inclusion is confirmed through the analysis of TB versus the mean volume of the nanoparticles and the law of approach to saturation. Maximum magnetization is achieved for x = 0.5 as a result of the cation distribution between octahedral and tetrahedral spinel sites, analysed by neutron diffraction studies. The occurrence of a canted spin arrangement (Yafet-Kittel angle) is introduced to properly fit the magnetic spinel structures. Finally, the heating capacity of these spinel ferrites is analyzed under ac magnetic field (magnetic hyperthermia). Maximum SAR (Specific Absorption Rate) values are achieved for x = 0.5 that should be correlated to the maximum magnetic moment of this composition., The work has been performed within the framework of projects MAT2017-83631-C3-2-R (Spanish "Ministerio de Economía, Industria y Competitividad") and DRUG-MAG, Nueva generación de plataformas teragnósticas contra el cáncer asistidas por partículas superparamagnéticas (Gobierno de Navarra, Departamento de Desarrollo Económico). J. Lopez-Garcia acknowledges ILL for his Ph.D. contract. E. C. Mendonca, J. G. S. Duque thank to Brazilian agencies FAPITEC (PRONEX) and CNPq (455608/2014-8).
Contactless magnetic nanoparticle detection platform based on non-linear GMI effect
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Beato López, Juan Jesús
- Algueta-Miguel, Jose M.
- Gómez Polo, Cristina
A detection platform based on non-linear Giant Magnetoimpedance Effect was analyzed for the design of a contactless and low-cost detector of magnetic nanoparticles. The sensor consists of two soft magnetic amorphous wires (Co66Fe2Si13B15Cr4, 1.5 cm in length) placed in parallel and connected electrically in series. Initially, a simple voltage divider was employed to characterize the variations of the first, V1fand second harmonic, V2f, voltages. Their response was analyzed under the effect of the remnant magnetic field generated by different amounts of Fe3O4 nanoparticles (mean diameter 140 nm) as a function of an external magnetic field, H. Due to the larger relative variations showed by V2f, the second harmonic was chosen for the final prototype development. An electronic interface was designed for both current excitation and V2f detection. The designed detection platform, characterized by high detection sensitivity, low-cost, portable, and reusable features, can be employed to efficiently detect magnetic nanoparticles., The work has been performed within the framework of the project MAT 2017-83631-C3-2R (Spanish Ministerio de Ciencia e Innovación) and AEI/FEDER (grant PID2019-107258RB-C32). The soft magnetic wire was kindly provided by Dr. A. Mitra, from NDE & Magnetic Materials Group, CSIR-National Metallurgical Laboratory, Jamshedpur 831007, India. The authors would also like to acknowledge the use of 'Servicio General de Apoyo a la Investigación-SAI', Universidad de Zaragoza for the TEM microscopy service.
Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Gandía, David
- Gandarias, Lucía
- Rodrigo, Irati
- Robles García, Joshua
- Das, Raja
- Garayo Urabayen, Eneko
- García, José Ángel
Magnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications., Spanish Government is acknowledged for funding under the project number MAT2017-83631-C3. USF coauthors acknowledge support from U.S. Department of Energy, Office of Basic Energy Sciences under Award No. DE-FG02-07ER46438.
Influence of the geometry on the performance of GMI in meander configuration
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Beato López, Juan Jesús
- Lete, N.
- García-Arribas, A.
- Gómez Polo, Cristina
The effect of geometry on Giant Magnetoimpedance effect (GMI) in a meander structure composed of three amorphous magnetic ribbons ((Co0.94 Fe0.06)72,5 Si12.5 B15; 20 mm length) connected electrically in series is analyzed. The impedance behavior under the meander configuration is compared with the sum configuration, namely, the sum of the impedance of each ribbon measured individually. The geometry effect in GMI response is examined by changing the distance, = 0.5, 1 and 2 cm, between ribbons in the meander. The highest GMI ratio is found for = 0.5 cm, with a gradual decrease for increasing distances. The lowest ratio corresponds to the sum configuration. The analysis of the results shows that this behavior of the GMI ratio, dominated by inductance, is determined by the overall negative contribution of the mutual inductance established between ribbons, and not by any intrinsic modification of the GMI effect in the meander structure., The authors want to acknowledge the funding from the Spanish Government (grants MAT2017-83631-C3-2-R, PID2020-116321RB-C21 and PID2020-115704RB-C32 all funded by Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033). Besides, we want to acknowledge the funding of the Public University of Navarre (project PJUPNA2005) and the Basque Government (grants IT1245-19 and doctoral fellowship of N. L).
Identifying the presence of magnetite in an ensemble of iron-oxide nanoparticles: a comparative neutron diffraction study between bulk and nanoscale
Digital.CSIC. Repositorio Institucional del CSIC
- González-Alonso, D.
- Espeso, J. I.
- Gavilán, Helena
- Zeng, L. J.
- Fernández-Díaz, M. T.
- Subías, G.
- Pedro, I. de
- Rodríguez Fernández, J.
- Bender, P.
- Fernández Barquín, L.
- Johansson, Christer
Scientific interest in iron-oxides and in particular magnetite has been renewed due to the broad scope of their fascinating properties, which are finding applications in electronics and biomedicine. Specifically, iron oxide nanoparticles (IONPs) are gathering attraction in biomedicine. Their cores are usually constituted by a mixture of maghemite and magnetite phases. In view of this, to fine-tune the properties of an ensemble of IONPs towards their applications, it is essential to enhance mass fabrication processes towards the production of monodisperse IONPs with controlled size, shape, and stoichiometry. We exploit the vacancy sensitivity of the Verwey transition to detect the presence of magnetite. Here we provide direct evidence for the Verwey transition in an ensemble of IONPs through neutron diffraction. This transition is observed as a variation in the Fe magnetic moment at octahedral sites and, in turn, gives rise to a change of the net magnetic moment. Finally, we show this variation as the microscopic ingredient driving the characteristic kink that hallmarks the Verwey transition in thermal variation of magnetization., This work has received funding from EU FP7 604448 (NanoMag) and MAT2017-83631-C3-R. The Institute Laue-Langevin is acknowledged for provision of beamtime on the D1B instrument., Peer reviewed
Pressure dependence of the Griffiths-like phase in 5:4 intermetallics
Digital.CSIC. Repositorio Institucional del CSIC
- Marcano, Noelia
- Algarabel, Pedro A.
- Rodríguez Fernández, J.
- Araujo, João Pedro
- Pereira, André M.
- Belo, João Horta
- Magén, César
- Morellón, Luis
- Ibarra, M. Ricardo
We report a study of the effect of hydrostatic pressure (P) on the Griffiths-like phase in selected compounds of the 𝑅5(Si𝑥Ge1−𝑥)4 family of alloys (Tb4.925La0.075Si2Ge2 and Gd5Ge4) which present either the Gd5Si2Ge2-type (monoclinic, M) or the Sm5Ge4-type [orthorhombic-II, O(II)] structural phases at room temperature. The downward deviation in the inverse low-field dc susceptibility 𝜒−1 𝑑𝑐 from the Curie-Weiss law below a characteristic temperature 𝑇𝐺 indicates that the Griffiths-like phase exists at pressures up to 10 kbar. From the obtained T-P phase diagrams, the pressure coefficient of the Griffiths-like temperature, 𝑑𝑇𝐺/𝑑𝑃, has been determined. These results are compared with those obtained in Dy5Si3Ge in a previous work. The 𝑑𝑇𝐺/𝑑𝑃 coefficient is strongly dependent on the nature (first or second order) of the long-range order (FM or AFM) transition. This effect can be ascribed to a different structural character of the clusters within the Griffiths phase. A ratio of ∼0.5 between the 𝑑𝑇𝐺/𝑑𝑃 and the pressure coefficient of long-range magnetic ordering temperatures, 𝑑𝑇𝐶,𝑁/𝑑𝑃 (𝑇𝐶, ferromagnetic; 𝑇𝑁, antiferromagnetic), is found in all the studied compounds., Work at the University of Zaragoza is supported by the Spanish Ministerio de Ciencia, Innovación y Universidades through Project No. MAT2017-82970-C2-2-R and the
Aragon Regional Government (Grant No. E28_20R). Work at the University of Cantabria is supported by the Spanish Ministerio de Ciencia, Innovación y Universidades through
Project No. MAT2017-83631-C3-R. J.H.B. would like to thank FCT for Grant No. SFRH/BD/88440/2012, Project No. PTDC/FIS-MAC/31302/2017, and his Contract No.
DL57/2016, Reference No. SFRH-BPD-87430/2012., Peer reviewed
Aragon Regional Government (Grant No. E28_20R). Work at the University of Cantabria is supported by the Spanish Ministerio de Ciencia, Innovación y Universidades through
Project No. MAT2017-83631-C3-R. J.H.B. would like to thank FCT for Grant No. SFRH/BD/88440/2012, Project No. PTDC/FIS-MAC/31302/2017, and his Contract No.
DL57/2016, Reference No. SFRH-BPD-87430/2012., Peer reviewed