[EN] Several polyurethane-formulated films with curcumin and/or chitosan additives for food packaging have been previously obtained. The study examines the effect of the additives on the film¿s morphological, mechanical, barrier, and migration properties. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), water contact angle, thermogravimetric and differential thermal analysis (TGA and DTGA), differential scanning calorimetry (DSC), dynamic mechanical thermal analysis (DMTA), oxygen transmission rate (OTR), water vapor transmission rate (WVTR), and the overall and specific migration tests were conducted. The results show that the presence of chitosan significantly increased the overall migration and mechanical properties, such as the elongation at break, tensile strength, and Young¿s modulus of most polyurethane formulations, while curcumin had a minor influence on the mechanical performance. Based on the results, formulations with curcumin but without chitosan are suitable for food packaging., This research was funded by Universidad de La Sabana, grant number ING-289-2021.
The APC was funded by Universidad de La Sabana and the Centre for Biomaterials and Tissue
Engineering at Universitat Politècnica de València. CIBER-BBN, Biomedical Research Networking
Center in Bioengineering, Biomaterials, and Nano-medicine is an initiative funded by the VI National
R&D&I Plan 2008¿2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions were financed
by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund.
J.A.G.-T thanks MCIN/AEI/10.13039/501100011033 grant number PID2020-114894RB-I00.

[ES] Los sistemas de liberación controlada de fármacos surgen como alternativa a los métodos tradicionales con el fin de mejorar la eficacia de los tratamientos, pudiendo adaptar la localización y periodo de tiempo de administración los mismos. En este Trabajo Final de Grado se ha utilizado la técnica de electrohilado para fabricar fibras de diámetros nano y micrométricos para emplearse como vehículo para la liberación controlada de ciprofloxacino, un antibiótico utilizado en el tratamiento postoperatorio de la cirugía de cataratas. El electrohilado tiene dos configuraciones que permiten obtener fibras con distinta morfología: con el electrohilado uniaxial se consiguen fibras homogéneas compuestas por un único material, mientras que el coaxial da lugar a fibras formadas por un núcleo y un recubrimiento. Esta estructura es idónea para la liberación de fármacos, pues el núcleo puede estar formado por una matriz de un polímero de rápida degradación que contenga el ciprofloxacino y la cubierta por un material con un perfil de degradación más lento que permita controlar la velocidad de liberación del dispositivo biomédico. Los materiales seleccionados fueron el alcohol polivinílico (PVA) para el núcleo y el ácido poli-L-láctico (PLLA) para el recubrimiento debido a que cumplían a la perfección las características mencionadas. Se fabricaron membranas mediante electrohilado uniaxial y coaxial a distintas concentraciones de los polímeros y se estudiaron sus propiedades y funcionamiento como sistemas de liberación controlada de ciprofloxacino con el fin de determinar cuál era el modelo que más se ajustaba a las necesidades planteadas., [EN] Controlled drug delivery systems emerge as an alternative to traditional methods with the aim of improving treatment efficacy by adapting the location and duration of drug administration. In this Final Degree Project, the electrospinning technique was used to manufacture fibers with nano and micrometric diameters to serve as vehicles for the controlled release of ciprofloxacin, an antibiotic used in postoperative treatment of cataract surgery. Electrospinning has two configurations that allow for obtaining fibers with different morphologies: uniaxial electrospinning produces homogeneous fibers composed of a single material, while coaxial electrospinning results in fibers formed by a core and a coating. This structure is ideal for drug delivery, as the core can be made of a rapidly degrading polymer matrix containing ciprofloxacin, and the coating can be made of a material with a slower degradation profile, which helps control the release rate of the biomedical device. The selected materials were polyvinyl alcohol (PVA) for the core and poly-L-lactic acid (PLLA) for the coating, as they perfectly met the required characteristics. Membranes were fabricated using uniaxial and coaxial electrospinning at different polymer concentrations, and their properties and performance as controlled ciprofloxacin release systems were studied to determine which model best met the proposed needs., [CA] Els sistemes de lliberació controlada de fàrmacs sorgeixen com una alternativa als mètodes tradicionals amb la finalitat de millorar l'eficàcia dels tractaments, podent adaptar la localització i el període de temps d'administració dels mateixos. En aquest Treball Final de Grau s'ha utilitzat la tècnica d'electrofilat per a fabricar fibres de diàmetres nano i micromètrics per a emprar-se com a vehicle per a la lliberació controlada de ciprofloxacino, un antibiòtic utilitzat en el tractament postoperatori de la cirurgia de cataractes. L'electrofilat té dues configuracions que permeten obtenir fibres amb distinta morfologia: amb l'electrofilat uniaxial s'aconsegueixen fibres homogènies compostes per un únic material, mentre que el coaxial dona lloc a fibres formades per un nucli i un recobriment. Aquesta estructura és idònia per a la lliberació de fàrmacs, ja que el nucli pot estar format per una matriu d'un polímer de ràpida degradació que continga el ciprofloxacino i la coberta per un material amb un perfil de degradació més lent que permeta controlar la velocitat de lliberació del dispositiu biomèdic. Els materials seleccionats van ser l'alcohol polivinílic (PVA) per al nucli i l'àcid poli-L-làctic (PLLA) per al recobriment, ja que complien a la perfecció les característiques esmentades. Es van fabricar membranes mitjançant electrofilat uniaxial i coaxial a distintes concentracions dels polímers i es van estudiar les seues propietats i funcionament com a sistemes de lliberació controlada de ciprofloxacino amb la finalitat de determinar quin era el model que més s'ajustava a les necessitats plantejades.

[EN] Green solvent strategies are increasingly important for advancing sustainable polymer processing and deepening the understanding of structure-property relationships. In this work, we report a coaxial electrospinning approach that employs dimethyl sulfoxide and ethyl acetate as environmentally benign solvents to fabricate nanofibers composed of polyvinyl alcohol (PVA) cores and poly(L-lactic acid) (PLLA) shells. Comprehensive morphological and physicochemical characterization confirmed the successful formation of uniform, defect-free core-shell architectures. Comparative transport studies revealed clear architecture-dependent behavior: uniaxial PVA fibers displayed rapid burst release, PLLA-only fibers acted as complete diffusion barriers, and coaxial PVA/PLLA fibers enabled finely tunable, diffusion-controlled transport over extended timescales. These findings establish direct links between solvent choice, processing architecture, and transport properties in biodegradable nanofiber systems. This study provides both a scalable eco-conscious electrospinning strategy and a fundamental framework for correlating processing, morphology, and mass transport in polymeric materials., Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research and APC were funded by MCIN/AEI/https://doi.org/10.13039/501100011033 grant number PID2020-114894RB-I00.

[EN] The increased demand for vascular grafts for the treatment of cardiovascular diseases has led to the search for novel biomaterials that can achieve the properties of the tissue. According to this, the investigation of polyurethanes has been a promising approach to overcome the present limitations. However, some biological properties remain to be overcome, such as thrombogenicity and hemocompatibility, among others. This paper aims to synthesize polyurethanes based on castor oil and castor oil transesterified with triethanolamine (TEA) and pentaerythritol (PE) and with the incorporation of 1% chitosan. Analysis of the wettability, enzymatic degradation, mechanical properties (tensile strength and elongation at break), and thermal stability was performed. Along with the evaluation of the cytotoxicity against mouse fibroblast (L929) and human dermal fibroblast (HDFa) cells, the hemolysis rate and platelet adhesion were determined. The castor-oil-based polyurethanes with and without 1% chitosan posed hydrophobic surfaces and water absorptions of less than 2% and enzymatic degradation below 0.5%. Also, they were thermally stable until 300 °C, with tensile strength like cardiovascular tissues. The synthesized castor oil/chitosan polyurethanes are non-cytotoxic (cell viabilities above 80%) to L929 and HDFa cells and non-thrombogenic and non-hemolytic (less than 2%); therefore, they are suitable for cardiovascular applications., This research was funded by Universidad de La Sabana, project number ING-282-2021.

[EN] This dataset presents data for electrospun membranes developed for controlled drug release applications. Both uniaxial Polyvinyl alcohol (PVA) and coaxial fibers with a PVA core and a poly (L-lactic acid) (PLLA) and polycaprolactone (PCL) coating were produced with different coating structures. The best conditions for the manufacture of the fibers were also studied and their morphology was analyzed as a function of the electrospinning parameters. Special attention was paid to the fiber surface morphology of the coaxial fibers, obtaining both porous and non-porous coatings. Bovine serum albumin (BSA) was used as the model protein for the drug release studies and, as expected, the uncoated fibers were determined to have the fastest release kinetics. Different release rates were obtained for the coated fibers, which makes this drug release system suitable for different applica-tions according to the release time required., This research was funded by MCIN/AEI/10.13039/501100011033 grant number PID2020-114894RB-I00.

[EN] In this study, electrospun membranes were developed for controlled drug release applications. Both uniaxial Polyvinyl alcohol (PVA) and coaxial fibers with a PVA core and a poly (L-lactic acid) (PLLA) and polycaprolactone (PCL) coating were produced with different coating structures. The best conditions for the manufacture of the fibers were also studied and their morphology was analyzed as a function of the electrospinning parameters. Special attention was paid to the fiber surface morphology of the coaxial fibers, obtaining both porous and non-porous coatings. Bovine serum albumin (BSA) was used as the model protein for the drug release studies and, as expected, the uncoated fibers were determined to have the fastest release kinetics. Different release rates were obtained for the coated fibers, which makes this drug release system suitable for different applications according to the release time required., This research and APC were funded by MCIN/AEI/10.13039/501100011033 grant number PID2020-114894RB-I00.