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- Raemdonck, Anne Van
This article looks at the way culture is represented in 3 commonly used course books of Dutch as a foreign language. According to the author, everyday culture of the regions where Dutch is spoken, is presented from a nationalistic point of view, i.e. it is limited to either cultural, historical and social aspects of The Netherlands or cultural, historical and social aspects of the Flemish Community in Belgium. The existence of the other region or country where the same language is spoken is not only ignored but at times even portrayed wrongfully which has its logically negative effect upon the students" interpretation and can lead to prejudice and the teachers using those course books.
See at: http://hdl.handle.net/2445/59613
‘HIJ’ VERSUS ‘ZIJ’: CONTRASTEN, PARALLELLEN EN BEELDSPRAAK IN LAIA FÀBREGAS’ LANDEN (2010), ‘HIM’ VERSUS ‘HER’: CONTRASTS, PARALLELS AND IMAGERY IN LAIA FÀBREGAS’ LANDEN (2010)
- van Raemdonck, Anne
In this article I shall show how deftly Fàbregas creates in her novel Landen two separate but thematically connected stories and leads them to a very satisfying and totally unexpected ending. Landen is an intriguing psychological novel where the two main characters, Him and Her, tell, in alternating chapters, their own story in the first person. They only meet once, in the first chapter, where the Him character dies. I shall first look at the main characters’ life experiences, i.e. the car accident in which the Her character loses her parents and the experiences of the Him character as an emigrant and later as a widower. I shall then describe the contrasting attitudes they each adopt and look at parallels between both narratives. Finally, I shall give an interpretation of the imagery as a link that also enhances the contrast between the characters., In this article I shall show how deftly Fàbregas creates in her novel Landen two separate but thematically connected stories and leads them to a very satisfying and totally unexpected ending. Landen is an intriguing psychological novel where the two main characters, Him and Her, tell, in alternating chapters, their own story in the first person. They only meet once, in the first chapter, where the Him character dies. I shall first look at the main characters’ life experiences, i.e. the car accident in which the Her character loses her parents and the experiences of the Him character as an emigrant and later as a widower. I shall then describe the contrasting attitudes they each adopt and look at parallels between both narratives. Finally, I shall give an interpretation of the imagery as a link that also enhances the contrast between the characters.
Lezers, boeken en lectuur van een humanistenkring in de zestiende eeuw: Boekbestellingen door Arias Montano en zijn Sevilliaanse vrienden
- Dávila Pérez, Antonio
Después de su salida de Amberes, Benito Arias Montano (ca. 1525/27-1598) mantuvo una frecuente correspondencia con la oficina tipográfica de Cristóbal Plantino. Las cartas no se limitaron a intercambiar noticias públicas y privadas; el teólogo español envió muy a menudo listas de títulos de libros que él o su cenáculo de humanistas sevillanos estaban interesados en comprar. Este artículo se centra en quince listas enviadas entre 1585 y 1596 y conservadas en el Museo Plantin-Moretus de Amberes. El autor no se limita a publicar una transcripción de los documentos, sino que también trata de identificar los títulos de los listados. En varios casos logra también encontrar información extra sobre el envío de los libros que realmente fueron comprados. Un análisis de estos listados arroja luz sobre los amplios intereses culturales y científicos de este grupo, así como sobre su situación socio-económica.
Evidence for a relationship between mitochondrial Complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: Effects of mitochondrial antioxidants
The medical use of nitroglycerin (GTN) is limited by patient tolerance. The present study evaluated the role of mitochondrial Complex I in GIN biotransformation and the therapeutic effect of mitochondrial antioxidants. The development of GIN tolerance (in rat and human vessels) produced a decrease in mitochondrial 02 consumption. Co-incubation with the mitochondria-targeted antioxidant mitoquinone (MQ 10(-6) mol/L) or with glutathione ester (GEE, 10(-4) mol/L) blocked GTN tolerance and the effects of GTN on mitochondrial respiration and aldehyde dehydrogenase 2 (ALDH-2) activity. Biotransformation of GTN depended on the mitochondria being functionally active, particularly mitochondrial Complex I. Tolerance induced mitochondrial ROS production and oxidative stress, though these effects were not detected in HUVEC rho(0) cells or Complex I mutant cells. Experiments performed to evaluate Complex I-dependent respiration demonstrated that its inhibition by GIN was prevented by the antioxidants in control samples. These results point to a key role for mitochondrial Complex I in the adequate functioning of ALDH-2. In addition, we have identified mitochondrial Complex I as one of the targets at which the initial oxidative stress responsible for GIN tolerance takes place. Our data also suggest a role for mitochondrial-antioxidants as therapeutic tools in the control of the tolerance that accompanies chronic nitrate use. (C) 2012 Elsevier B.V. All rights reserved.
The C-terminal region of the Hot1 transcription factor binds GGGACAAA-related sequences in the promoter of its target genes.
Response to hyperosmotic stress in the yeast Saccharomyces cerevisiae involves the participation of the general stress response mediated by Msn2/4 transcription factors and the HOG pathway. One of the transcription factors activated through this pathway is Hot1, which contributes to the control of the expression of several genes involved in glycerol synthesis and flux, or in other functions related to adaptation to adverse conditions. This work provides new data about the interaction mechanism of this transcription factor with DNA. By means of one-hybrid and electrophoretic mobility assays, we demonstrate that the C-terminal region, which corresponds to amino acids 610-719, is the DNA-binding domain of Hot1. We also describe how this domain recognizes sequence 5'-GGGACAAA-3' located in the promoter of gene STL1. The bioinformatics analysis carried out in this work allowed the identification of identical or similar sequences (with up to two mismatches) in the promoter of other Hot1 targets, where central element GGACA was quite conserved among them. Finally, we found that small variations in the sequence recognized by Hot1 may influence its ability to recognize its targets in vivo.
- Campos Bueno, José Javier
It is reviewed the iconography of Dutch-Sephardic philosopher Baruch Spinoza. It reports on the recent identification of the image of the philosopher found in an anonymous portrait deposited at the Universidad Complutense coming from Simarro Legacy Foundation. Documentation is provided showing that the portrait was painted by Sorolla for the library of Dr. Simarro. Repasa la iconografía del filosofo holandés de origen español-sefardí Baruch Spinoza. Da cuenta de la reciente identificación de la imagen del filósofo en un retrato anónimo depositado en la Universidad Complutense perteneciente al Legado de la Fundación Simarro. Se aporta documentación mostrando que el retrato fue pintado por Sorolla para la biblioteca del Dr. Simarro
See at: https://eprints.ucm.es/id/eprint/24979/1/Een%20portret%20van%20Spinoza%20geschilderd%20door%20Sorolla%20%282%29.pdf
Small heterodimer partner (SHP) is an atypical nuclear receptor expressed in heart that has been shown to inhibit the hypertrophic response. Here, we assessed the role of SHP in cardiac metabolism and inflammation. Mice fed a high-fat diet (HFD) displayed glucose intolerance accompanied by increased cardiac mRNA levels of Shp. In HL-1 cardiomyocytes, SHP overexpression inhibited both basal and insulin-stimulated glucose uptake and impaired the insulin signalling pathway (evidenced by reduced AKT and AS160 phosphorylation), similar to insulin resistant cells generated by high palmitate/high insulin treatment (HP/HI; 500µM/100nM). In addition, SHP overexpression increased Socs3 mRNA and reduced IRS-1 protein levels. SHP overexpression also induced Cd36 expression (~6.2 fold; p0.001) linking to the observed intramyocellular lipid accumulation. SHP overexpressing cells further showed altered expression of genes involved in lipid metabolism, i.e., Acaca, Acadvl or Ucp3, augmented NF-?B DNA-binding activity and induced transcripts of inflammatory genes, i.e., Il6 and Tnf mRNA (~4-fold induction, p0.01). Alterations in metabolism and inflammation found in SHP overexpressing cells were associated with changes in the mRNA levels of Ppara (79% reduction, p0.001) and Pparg (~58-fold induction, p0.001). Finally, co-immunoprecipitation studies showed that SHP overexpression strongly reduced the physical interaction between PPARa and the p65 subunit of NF-?B, suggesting that dissociation of these two proteins is one of the mechanisms by which SHP initiates the inflammatory response in cardiac cells. Overall, our results suggest that SHP upregulation upon high-fat feeding leads to lipid accumulation, insulin resistance and inflammation in cardiomyocytes.