Encontrados 3693518 resultado(s)
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Encontradas 36936 página(s)
EndoCompass project: research roadmap for growth disorders
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Gevers, EF, Hokken-Koelega, AC, Tauber, M, Binder, G, Bochukova, EG, Bouret, SG, Caixàs, A, Davies, JH, Dauber, A, Edouard, T, Eggermann, T, Giabicani, E, Netchine, I, Nilsson, O, Saravinovska, K, van der Steen, M, Tartaglia, M, Tatton-Brown, K, Temple, IK, Yart, A, Zenker, M
Background Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At the national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project-a joint initiative between the...
Therapeutic Alliances for Optimizing the Management of Patients with Prostate Cancer: SOGUG Multidisciplinary Expert Panel Recommendations
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
González-del-Alba, A, Ballesteros, CM, Arranz, JA, Gallardo, E, Sarrió, RG, Campos, FL, Muñoz-Rodríguez, J, Méndez-Vidal, MJ, de Iturriaga, AG
A group of Spanish experts of different specialties participated in the ENFOCA2 project, promoted by the Spanish Oncology Genitourinary Group (SOGUG), which was designed to provide updated information on current and novel aspects contributing to the optimal care of prostate cancer (PCa) patients. In localized disease, it is important to implement strategic alliances with other institutions for improving adherence to active surveillance in low-risk groups and to explore genetic testing for a...
Impact of the new EASO obesity definition on the detection of atheromatosis in subjects with low-to-moderate cardiovascular risk
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
León-Mengíbar, J, Bermúdez-López, M, Valdivielso, JM, Pamplona, R, Torres, G, Mauricio, D, Castro-Boqué, E, Fernández, E, Caixàs, A, Bueno, M, Ciudin, A, Hernández, M, Simó, R, Hernández, C, Lecube, A
Background: Traditional body mass index (BMI) does not adequately reflect adipose tissue distribution and associated cardiovascular (CV) risk. To improve risk stratification, the European Association for the Study of Obesity (EASO) proposes to extend the diagnosis of obesity to include individuals with a BMI of 25-30 kg/m(2), a waist-to-height ratio (WtHR) >= 0.5, and any obesity-related complication. Objective: To examine whether this new definition of obesity can better identify the...
Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Fernández-Morata, J, Pollán, M, de Larrea-Baza-Baz, NF, Pachón-Olmos, V, García-Pérez, J, Castelló, A, Sierra, MA, Lucas, P, Llobet, R, Stradella, A, Cantos, B, Cajal, T, Santisteban, M, Seguí, MA, Bertrán, AS, Granja, M, Camps-Herrero, J, Recalde, S, Nuñez-García, B, Verges, NC, Pérez-Gómez, B, Pastor-Barriuso, R, Lope, V
Background Mammographic density (MD) is an established biomarker of breast cancer (BC) risk. However, its relationship to BC pathological subtypes remains unclear. This study aimed to investigate this association and assess whether it differs by body mass index (BMI) and menopausal status. Methods MD percentage was assessed in the diagnostic mammograms of the contralateral breast of 714 BC patients recruited from eight Spanish hospitals. Participants completed an epidemiological questionnaire,...
Long-term prognostic implications of type 2 diabetes mellitus in colorectal cancer patients
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Alcaide-Garcia, J, Boughanem, H, García-Aranda, M, Rivas-Ruiz, F, Aguirre, U, García, DM, Padilla-Ruiz, M, Varela-Moreno, E, Robles-Lasarte, M, Baré, M, del Cura, I, Varela, MMM, Quintana, JM, Macías, M, Redondo, M
Aim Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Epidemiological evidence has identified Type 2 Diabetes Mellitus (T2DM) as a risk factor for CRC. This study aimed to evaluate the impact of T2DM, along with clinicopathological and socio-demographic factors, on long-term overall survival in a large, nationally representative cohort of CRC patients with T2DM. Method A prospective cohort of 1186 CRC patients was analysed, approximately 20% of whom had a diagnosis of T2DM...
Patient-reported outcome measures poorly correlate with objective inflammatory bowel disease activity measures: a systematic review
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Calvet, X, Ferrario, MG, Marfil, V, Armenteros, S, Acosta, MBD
Background and Aims We investigated the correlations between patient-reported outcome measures (PROMs) and other measures of inflammatory bowel disease (IBD) activity.Methods A systematic literature review was performed up to June 2022. Searches were conducted in PubMed, Scopus, and Web of Science. A descriptive analysis was performed. The search protocol was registered in PROSPERO (CRD42022383899).Results Nineteen studies assessed correlations between PROMs and clinical, endoscopic, and...
Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Vilor-Tejedor, N, Rodrigo, A, Genius, P, Rodríguez-Fernández, B, Anastasi, F, Pelkmans, W, Navarro, A, Adams, HH, Wisse, L, Gispert, JD, Evans, TE, ADN
The hippocampus, crucial in cognitive aging and Alzheimer's disease (AD), shows early atrophy during disease progression. This study investigated 5-year trajectories of hippocampal volumes across AD stages, focusing genetic predisposition to AD, captured through the polygenic risk score for AD (PRS-AD) and APOE, and their impact on hippocampal atrophy. Analyzing data from 1,051 participants in the ADNI, we found that AD genetic risk accelerates a reduction in hippocampal volume,...
The role of Fezolinetant in fear memory consolidation
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Fronza, MG, Torrent, M, Andero, R
Modulation of fear memories has important implications for the treatment of different psychiatric disorders including fear-based disorders such as posttraumatic stress disorder (PTSD). The Tachykinin2 (Tac2)/Neurokinin B (NkB)/neurokinin 3 receptor (Nk3R) pathway is a potential candidate for treating fear-based disorders built on animal and human studies. Here we demonstrate that the Nk3R antagonist Fezolinetant presents sex-divergent effects in the processing of fear memories in mice exposed...
Emotions in patients with refractory or unexplained chronic cough: a multicenter, non-interventional study
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Arismendi, E, Puente-Maestu, L, Domingo, C, Dávila, I, Quirce, S, Sánchez-Jareño, M, Cea-Calvo, L
Background: Chronic cough (CC) has a negative effect on patients' quality of life and everyday activities. Emotional reactions are an important aspect of how patients deal with illness, and CC can lead to feelings of uncertainty, loss of control, helplessness, self-consciousness, embarrassment, worry, fear, frustration, irritability, and anger.Objectives: To assess the emotions related to bouts of cough in patients with refractory or unexplained chronic cough (RCC/UCC), using a validated...
Disease Burden and Treatment Patterns in Patients With Hidradenitis Suppurativa and Concomitant Arthritis: A Multicenter Case-Control Study
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Garbayo-Salmons, P, Molina-Leyva, A, Porta-Vilaró, A, Soto-Moreno, A, Fornons-Servent, R, Gamissans, M, Garcias-Ladaria, J, Gracia-Darder, I, Martin-Ezquerra, G, Verdaguer-Faja, J, Mora-Fernández, V, Aguayo-Ortiz, RS, Vilarrasa, E, Masferrer, E, Corral-Magaña, O, Galvany, L, Rodrigo-Parés, A, Saus, E, Moreno, M, Carreras, A, Feliu-Hernàndez, C, Exposito-Serrano, V, Ribera, M, Sabat, M, Calvet, J
Background: The relationship between hidradenitis suppurativa (HS) and arthritis is well-established; however, the impact of their combined disease burden and the associated treatment pattern has not been determined yet. This study aimed to assess disease burden and therapeutic approaches in HS patients with and without arthritis and estimate arthritis prevalence and subtypes. Methods: A multicenter, retrospective, case-control study of 272 adults (69 with HS and arthritis; 203 with HS only),...
Definition of resectable stage III non-small cell lung cancer (NSCLC) for inclusion in clinical trials: A clinical case review by a pan-European multidisciplinary expert panel led by the EORTC Lung Cancer Group
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Brandao, M, Prisciandaro, E, Xenophontos, E, Mariolo, A, Sadeghi, AH, Filippi, AR, Levy, A, Bandura, A, Caramella, C, Dickhoff, C, de Margerie-Mellon, C, Faivre-Finn, C, Portik, D, Sanchez-Lorente, D, De Ruysscher, D, Smit, E, Gobbini, E, Fadel, E, Ruffini, E, Olmetto, E, Cortiula, F, Bahce, I, Houda, I, Opitz, I, Naidoo, J, Edwards, J, Remon, J, Benitez, JC, Trujillo, JC, Derks, J, Amrane, K, Hartemink, KJ, Stathopoulos, K, Hendriks, LEL, Iglesias, M, Occhipinti, M, Guckenberger, M, Levra, NG, Girard, N, Reguart, N, Mercier, O, Bironzo, P, Hofman, P, Petersen, RH, De Angelis, R, Abgral, R, Terrisse, S, Popat, S, Pierret, T, Blum, TG, Ricardi, U, Dionisi, V, Berghmans, T, Dingemans, AMC
Introduction: Stage III non-small cell lung cancer (NSCLC) is a heterogeneous disease, leading to ambiguity in resectability criteria. This has prompted the EORTC Lung Cancer Group to establish a standardized definition of resectability for clinical trials. A Delphi consensus process was initiated, including a systematic review, survey, and clinical cases review. Here, we report exclusively the results of the clinical cases review, aimed to categorize cases based on tumor and lymph node factors...
Barcelona Progressive Supranuclear Palsy (PSP) Registry: Clinical, Oculomotor, and Cerebrospinal Fluid Markers; from Suggestive to Definite Cases
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Painous, C, Fernández, M, Cámara, A, Alba-Arbalat, S, Soto, M, Brenlla, C, Muñoz, E, Pérez-Soriano, A, Valldeoriola, F, Martí, MJ, Tolosa, E, Garrido, A, Sánchez-Gómez, A, Maragall, L, Camós-Carreras, A, Tió, M, Martín, N, Basora, M, Buongiorno, M, Pont-Sunyer, MC, Delgado, T, Planas-Ballvé, A, Caballol, N, Avila, A, Vilas, D, Jaumà, S, Marco, C, de Fàbregues, O, Matos, N, Mas, A, Mas, N, Aragonés, JM, Bejr-Kasem, H, Navarro-Otano, J, Montori-Palacín, E, Balasa, M, Sarto, J, Borrego-Écija, S, Roldán, P, Perissinotti, A, Molina-Porcel, L, Aldecoa, I, Pérez-Montesino, J, De Mena, L, Naranjo, L, Ruiz-García, R, Compta, Y
Background Timely and accurate diagnosis of progressive supranuclear palsy (PSP) remains challenging. Objective To assess diagnostic certainty and progression biomarkers in the PSP spectrum from "suggestive of" (so-PSP) category as proxy of early disease, to definite (neuropathologically confirmed) cases. Methods Multicenter, prospective, longitudinal study of 131 participants (so-PSP, n = 23; definite, n = 5) with oculometric (n = 47) and cerebrospinal fluid (CSF) biomarkers (n = 75...
Personalized Follow Up and Genetic Diagnosis Update of FMR1-Related Conditions: A Change in Diagnosis, Prognosis and Expectations
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Roche-Martínez, A, Ramírez-Mallafré, A, Joga-Elvira, L, Manso-Bazus, C, Rubio-Roy, M, Baena-Diez, N
Fragile X syndrome (FXS, OMIM#300624) is the most common inherited cause of X-linked intellectual disability and behavior difficulties. In 99% of cases, it is caused by the pathological expansion (>200 repeats, full mutation -FM) of the CGG trinucleotide located at the 5 ' UTR of the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, leading to the lack of production of the FMRP. Clinical manifestations are well known in boys but are sometimes overlooked in girls, who may remain...
Ultrasound-guided ethanol sclerotherapy versus laparoscopic surgery for endometriomas: a randomized clinical trial in a real-world setting
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
García-Tejedor, A, Guevara-Peralta, R, Martinez-Garcia, JM, Corbalán, S, Agüero, M, Gomez-Romero, M, Cararach, M, Castellarnau, M, Rodríguez, M, Lou-Mercadé, AC, Costa, L, Rodríguez, MJ, Huguet, E, Carreras, M, Castel-Segui, AB, Font-Roig, M, Royo, S, Sarasa, N, Candas, B, Perez-Carton, S, Ortega, C, Pla, MJ, Ponce, J
Purpose To compare the efficacy of ultrasound-guided alcohol sclerotherapy versus laparoscopic cystectomy for the management of ovarian endometriomas, focusing on complications, recurrence, pain relief, and healthcare costs. Methods We conducted a multicentre, randomized clinical trial across 20 centers in Spain. A total of 167 women aged 18-40 years with ovarian endometriomas (35-100 mm) were recruited between June 2018 and June 2022. Participants were randomized to receive either ultrasound-...
Increased Driving Pressure During Assisted Ventilation for Hypoxemic Respiratory Failure Is Associated with Lower ICU Survival The ICEBERG Study
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Grassi, A, Bianchi, I, Droghi, MT, Miori, S, Bruno, I, Balzani, E, Morris, IS, Schaedler, D, Becher, T, Marchal, MV, Serrano, JM, Caritg, O, Roca, O, Costa, E, Amato, M, Barriga, F, Roldan, R, Boffi, A, Piquilloud, L, Mitchon, GJ, Musch, G, Piva, S, Bertoni, M, Castagna, L, Grasselli, G, Riccardo, M, Spadaro, S, Nita, C, Mcnicholas, B, Sklar, MC, Magliocca, A, Rezoagli, E, Foti, G, Laffey, J, Brochard, LJ, Goligher, EC, Bellani, G
Rationale: Driving pressure (DP) is a marker of severity and a possible target for lung protection during controlled ventilation, but its value during assisted ventilation is unknown. Inspiratory holds provide an estimate of DP that is quasi-static. Expiratory holds provide an estimate of the inspiratory effort, which is useful to estimate the transpulmonary dynamic DP. Objectives: To assess the correlation between DPs measured during assisted ventilation and ICU outcomes. Methods: Multicenter...
Unraveling the gut-fat-inflammation connection in Crohn's disease: A path to new therapeutic targets?
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Giordano, A, Bastón-Rey, I, Madero, L, Brunet-Mas, E, Calafat, M
Efficacy of inhaled nebulised unfractionated heparin to prevent intubation or death in hospitalised patients with COVID-19: an investigator-initiated international meta-trial of randomised clinical studies
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
Van Haren, FMP, Valle, SJ, Neto, AS, Schultz, MJ, Laffey, JG, Artigas, A, Dixon, B, Vilaseca, AB, Barbera, RA, Ismail, TI, Mahrous, RS, Badr, M, Denucci, G, Sverdloff, C, Camprubi-Rimblas, M, Cosgrave, DW, McNicholas, B, Cody, C, Curley, G, Smoot, TL, Staas, S, Sann, K, Sas, C, Belani, A, Hillman, C, Manggala, SK, Aditianingsih, D, Sugiarto, A, Yulianti, M, Herikurniawan, H, Sinto, R, Auerkari, AN, Permana, SA, Woodcock, A, Carroll, M, Wilkinson, T, Singh, D, Shute, JK, Carroll, M, Page, C
Background Inhaled nebulised unfractionated heparin (UFH) has a strong rationale as a treatment for severe respiratory infections, including COVID-19, due to its antiviral, anti-inflammatory, and anti-coagulant properties, which may prevent viral entry, lung injury progression, and pulmonary thrombosis. We aimed to evaluate the efficacy of inhaled nebulised UFH to prevent intubation or death in hospitalised COVID-19 patients. Methods In this prospective, a priori set up and defined,...
Information needs and barriers to patient-centered care in oncology: EtnobreastHER2, an ethnographic study with HER2+MBC patients and their healthcare providers
Repositorio: r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
García-Sáenz, JA, Rodríguez-Lescure, A, Antolin, S, Cantos, B, Seguí, MA, Gimón, MA, Renau, RR, Marsiñach, CS, Illán, JM, Vallejo, RF, Guadalupe, YG, Oliver, NA, Gavilá, J
Introduction and objectives Qualitative evidence regarding the structural barriers embedded in healthcare ecosystems impacting Human Epidermal Growth Factor Receptor 2 metastatic breast cancer (HER2+ MBC) patients' communication and information needs is scarce. This study explored patient and healthcare professionals' perspectives on said structural barriers and communication delivery.Methods Ethnographic, qualitative, observational, multicenter and cross-sectional study with HER2+...